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Increased serum periostin concentrations are associated with the presence of diabetic retinopathy in patients with type 2 diabetes mellitus

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Abstract

Purpose

To determine the association between serum periostin and the presence of diabetic retinopathy (DR).

Methods

Serum periostin was detected in 114 healthy subjects, 122 patients with type 2 diabetes mellitus (T2DM) and 159 patients with DR and compared among groups. Clinical data and other laboratory measurements such as glycated hemoglobin (HbA1c), lipid profiles, serum creatinine (Cr) and high-sensitivity CRP (hsCRP) were also collected and compared among groups. For subgroup analysis, patients with DR were divided into a non-proliferated diabetic retinopathy (NPDR) group and a proliferated diabetic retinopathy (PDR) group. Multivariate analysis was performed using logistic regression models.

Results

The serum periostin level was significantly higher in patients with diabetic retinopathy compared with healthy subjects and patients with T2DM (both P < 0.001, respectively). Also, the periostin level was significantly higher in the PDR group compared to the NPDR group (P = 0.044). Multivariate logistic regression revealed that serum periostin was independently associated with the presence of DR in patients with T2DM (P < 0.001). The receiver operating characteristic (ROC) curves for DR development using serum periostin showed that the area under the receiver operating characteristic curves (AUC) was 0.838 (P < 0.001).

Conclusions

The current study demonstrated that serum periostin is significantly associated with the presence of DR in patients with T2DM and is an independent risk factor of DR.

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Acknowledgements

The author would like to thank the technical support from the Chongqing Key Laboratory of Translation Medicine in Major Metabolic Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. This study is supported by grants from the National Natural Science Foundation of China (81270911, 81070639, 30771038, and 30570744) and National Key Clinical Specialties Construction Program of China.

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Authors and Affiliations

  1. Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

    Y. Ding, Q. Ge, H. Qu, Z. Feng, J. Long, Q. Wei, Q. Zhou, R. Wu, L. Yao & H. Deng

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  1. Y. Ding
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  2. Q. Ge
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  3. H. Qu
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Correspondence to H. Deng.

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The authors declare that there is no conflict of interest regarding the publication of this article.

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The ethical committee of the First Affiliated Hospital of Chongqing Medical University approved this study. All procedures followed were performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from all patients for being included in the study.

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Ding, Y., Ge, Q., Qu, H. et al. Increased serum periostin concentrations are associated with the presence of diabetic retinopathy in patients with type 2 diabetes mellitus. J Endocrinol Invest 41, 937–945 (2018). https://doi.org/10.1007/s40618-017-0820-x

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