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Arsenic and Obesity: a Review of Causation and Interaction

  • Topical Collection on Metals and Health (R Fry and M Styblo, Section Editors)
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Abstract

Purpose of Review

Arsenic is associated with cancer, heart disease, diabetes, and other outcomes that are also related to obesity. These similar effects raise the possibility that arsenic plays a role in obesity causation. They also raise the possibility that obesity may be an important effect modifier of arsenic-caused disease. This review summarizes the complex relationship between arsenic and obesity, with an emphasis on current research from human studies.

Recent Findings

Experimental studies provide some evidence that arsenic could play a role in obesity pathogenesis. To date, however, these associations have not been confirmed in human studies. In contrast, several epidemiologic studies have shown that the risks of arsenic-caused disease are markedly higher in obese individuals, highlighting obesity as an important susceptibility factor.

Summary

Arsenic exposure and obesity are prevalent and widespread. Research identifying vulnerable populations, including obese individuals, could lead to new interventions having broad public health effects.

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Authors and Affiliations

  1. Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA

    Stephanie M. Eick

  2. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, 2470 Telegraph Ave., Suite 301, Berkeley, CA, 94704, USA

    Craig Steinmaus

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Eick, S.M., Steinmaus, C. Arsenic and Obesity: a Review of Causation and Interaction. Curr Envir Health Rpt 7, 343–351 (2020). https://doi.org/10.1007/s40572-020-00288-z

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