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Association between serum uric acid levels and coronary artery disease in different age and gender: a cross-sectional study

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Abstract

Background

The association between uric acid (UA) and coronary artery disease (CAD) was controversial. It was still unclear how the UA level changes with age and gender.

Aims

To confirm the relationship between the change of UA with age and gender and CAD, especially in elderly people.

Methods

8285 individuals were investigated. The changes of UA and hyperuricemia in female and male with age were analyzed. The associations of UA, and hyperuricemia with CAD in different age and sex were assessed.

Results

Individuals were stratified into four groups according to their age: ≤ 39 years; 40–59 years; 60–79 years, and ≥ 80 years. The level of UA and the proportion of hyperuricemia increased significantly with age in female (P < 0.001), but showed a downward trend in male (P < 0.001). After adjusting for confounding factors, hyperuricemia remained an independent risk factor for the incident of CAD in all women (P = 0.029). In ≥ 80 year groups of female, UA and hyperuricemia became independent risk factors for the incident of CAD in the univariate and multivariate logistic regression analyses (all P ≤ 0.001).

Discussion

The level of UA showed significantly different changes with age in different gender. The relationship between UA and CAD showed differences in different age and sex.

Conclusions

There were significant correlations between UA, hyperuricemia, and CAD only in female, particularly in the ≥ 80 year elderly women, but not in men.

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Data Availability

The data sets generated during the current study are not publicly available due. There are two major reasons: the first is that our study contains individual person’s data; the second is our data sets include many studies, and some of these studies are being carried on, so our data are not public, but are available partially from the corresponding author on reasonable request.

Abbreviations

UA:

Uric acid

CAD:

Coronary artery disease

BMI:

Body mass index

TG:

Triglyceride

TC:

Total cholesterol

HDL-C:

High-density lipoprotein cholesterol

LDL-C:

Low-density lipoprotein cholesterol

FPG:

Fasting plasma glucose

SBP:

Systolic blood pressure

DBP:

Diastolic blood pressure

ACEI/ARB:

Angiotensin-converting enzyme inhibitor/angiotensin receptor blocker

CCB:

Calcium channel blocker

HR:

Hazard ratio

CI:

Confidence interval

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Authors and Affiliations

  1. Department of Geriatric Cardiology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping Ward, Shenyang, 110001, China

    Yujiao Sun, Wen Tian, Liye Shi, Ling Chen, Jinyang Li, Shijie Zhao & Guoxian Qi

  2. Department of Geriatrics, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping Ward, Shenyang, 110001, China

    Haiyan Zhang

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  1. Yujiao Sun
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  3. Wen Tian
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  5. Ling Chen
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Correspondence to Guoxian Qi.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Sun, Y., Zhang, H., Tian, W. et al. Association between serum uric acid levels and coronary artery disease in different age and gender: a cross-sectional study. Aging Clin Exp Res 31, 1783–1790 (2019). https://doi.org/10.1007/s40520-019-01137-2

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  • DOI: https://doi.org/10.1007/s40520-019-01137-2

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