Abstract
Purpose of Review
While the epidemiology of North America’s opioid crisis has been well understood, a need exists to evaluate the potential for its expansion to other international settings. Thus, a comprehensive summary of the factors that have contributed to North America’s opioid crisis, their impact on global opioid markets, and relevance in other international settings is described.
Recent Findings
Increased opioid prescribing for pain management and the emergence of highly potent synthetic opioids (e.g., fentanyl) in North America’s illicit drug market have been identified as key drivers of its current opioid crisis.
Summary
Globally, trends demonstrate persistently high rates of opioid prescribing, rising non-medical prescription opioid use, and global opioid market diversification. Accordingly, significant potential exists for the emergence of an international opioid crisis. Prevention of this will require the adoption of evidence-based supply reduction strategies and a dramatic scale up of public health and addiction treatment interventions globally.
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References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
United Nations Office on Drugs and Crime. World drugs report 2017: executive summary. Austria: United Nations; 2017. 34 p. ISBN: 978–92–1-148291-1, eISBN: 978–92–1-060623-3. Available at: https://www.unodc.org/wdr2017/field/Booklet_1_EXSUM.pdf.
Centers for Disease Control and Prevention. Drug overdose death data [internet]. Atlanta: US Department of Health and Human Services; 2017 [cited July 13th, 2018]. Available at: https://www.cdc.gov/drugoverdose/data/statedeaths.html. This report provides a thorough description of opioid mortality in a US setting.
Special Advisory Committee on the Epidemic of Opioid Overdoses. National report: apparent opioid-related deaths in Canada (Jan 2016 to Dec 2017) web based report. Ottawa: Public Health Agency of Canada; June 2018 [cited July 13th, 2018]. Available at: https://www.canada.ca/en/public-health/services/publications/healthy-living/national-report-apparent-opioid-related-deaths-released-june-2018.html. This study provides a thorough description of opioid mortality in a Canadian setting.
United Nations Office in Drugs and Crime. World drug report 2017: drug demand and supply. Austria: United Nations; 2017. 68 p. ISBN: 978–92–1-148291-1, eISBN:978–92–1-060623-3. Available at: https://www.unodc.org/wdr2017/field/Booklet_2_HEALTH.pdf.
Berterame S, Erthal J, Thomas J, Fellner S, Vosse B, Clare P, et al. Use of and barriers to access to opioid analgesics: a worldwide, regional, and national study. Lancet. 2016;387(10028):1644–56.
United Nations Office on Drugs and Crime. World drug report 2018: executive summary. Austria: United Nations; 2018. 29 p. ISBN: 978–92–1–148304-8. Available at: https://www.unodc.org/wdr2018/prelaunch/WDR18_Booklet_1_EXSUM.pdf. This study provides a thorough description of updated global opioid markets.
Nigerian Epidemiological Network of Drug Use. Drug treatment information system in Nigeria: data analysis of 2015. UNODC, Dominique Lopez 2015.
Fischer B, Rehm J. Illicit opioid use in the 21st century: witnessing a paradigm shift? Addiction. 2007;102(4):499–501.
Fischer B, Rehm J, Brissette S, Brochu S, Bruneau J, El-Guebaly N, et al. Illicit opioid use in Canada: comparing social, health, and drug use characteristics of untreated users in five cities (OPICAN study). J Urban Health. 2005;82(2):250–66.
Gilson AM, Ryan KM, Joranson DE, Dahl JL. A reassessment of trends in the medical use and abuse of opioid analgesics and implications for diversion control: 1997-2002. J Pain Symptom Manag. 2004;28(2):176–88.
Cicero TJ, Inciardi JA, Muñoz A. Trends in abuse of Oxycontin and other opioid analgesics in the United States: 2002-2004. J Pain. 2005;6(10):662–72.
Compton WM, Volkow ND. Major increases in opioid analgesic abuse in the United States: concerns and strategies. Drug Alcohol Depend. 2006;81(2):103–7.
Darke S, Williamson A, Ross J, Teesson M. Reductions in heroin use are not associated with increases in other drug use: 2-year findings from the Australian treatment outcome study. Drug Alcohol Depend. 2006;84(2):201–5.
Seymour A, Black M, Jay J, Oliver JS. The role of dihydrocodeine in causing death among drug users in the west of Scotland. Scott Med J. 2001;46(5):143–6.
Drummer OH. Recent trends in narcotic deaths. Ther Drug Monit. 2005;27(6):738–40.
Hastie BA, Gilson AM, Maurer MA, Cleary JF. An examination of global and regional opioid consumption trends 1980-2011. J Pain Palliat Care Pharmacother. 2014;28(3):259–75.
Cherny NI, Cleary J, Scholten W, Radbruch L, Torode J. The Global Opioid Policy Initiative (GOPI) project to evaluate the availability and accessibility of opioids for the management of cancer pain in Africa, Asia, Latin America and the Caribbean, and the Middle East: introduction and methodology. Ann Oncol. 2013;24(Suppl 11):xi7–13.
Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0. Cancer incidence and mortality worldwide: IARC CancerBase No. 11. Available at: http://globocan.iarc.fr/Pages/summary_table_site_sel.aspx.
Manchikanti L, Singh A. Therapeutic opioids: a ten-year perspective on the complexities and complications of the escalating use, abuse, and nonmedical use of opioids. Pain Physician. 2008;11(2 Suppl):S63–88.
United Nations International Narcotics Control Board. Narcotic drugs: estimated world requirements for 2017; statistics for 2015. Vienna: United Nations International Narcotics Control Board; 2016. Available at: https://www.incb.org/documents/Narcotic-Drugs/Technical-Publications/2016/Narcotic_Drugs_Publication_2016.pdf.
United Nations International Narcotics Control Board. Narcotic drugs: estimated world requirements for 2012; statistics for 2010. Vienna: United Nations International Narcotics Control Board; 2011. Available at: https://www.incb.org/documents/Narcotic-Drugs/Technical-Publications/2011/Narcotic_Drugs_Report_2011.pdf
Becker WC, Fiellin DA. Limited evidence, faulty reasoning, and potential for a global opioid crisis. BMJ. 2017;358:j3115.
Senate US. Oxycontin: balancing risks and benefits. Hearing. 2002;107-287 Available at: https://www.gpo.gov/fdsys/pkg/CHRG-107shrg77770/html/CHRG-107shrg77770.htm.
Baker DW. History of the joint commission’s pain standards: lessons for today’s prescription opioid epidemic. JAMA. 2017;317(11):1117–8.
Fischer B, Keates A, Bühringer G, Reimer J, Rehm J. Non-medical use of prescription opioids and prescription opioid-related harms: why so markedly higher in North America compared to the rest of the world? Addiction. 2014;109(2):177–81.
Okie S. A flood of opioids, a rising tide of deaths. N Engl J Med. 2010;363(21):1981–5.
Fischer B, Rehm J, Tyndall M. Effective Canadian policy to reduce harms from prescription opioids: learning from past failures. CMAJ. 2016;188(17–18):1240–4.
US Food, Drug Administration. FDA announces results of investigation into illegal promotion of OxyContin by the Purdue Frederick Company [internet]. Maryland: US Department of Health and Human Services; 2007. [updated Sept 2017, accessed July 13th, 2018]. Available at: https://www.fda.gov/ForConsumers/ProtectYourself/HealthFraud/ucm432074.htm.
Center for Behavioral Health Statistics and Quality. 2014 national survey on drug use and health: detailed tables. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2015.
The DAWN report: highlights of the 2011 Drug Abuse Warning Network (DAWN) findings on drug-related emergency department visits. Rockville, MD: Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality, 2013.
Compton WM, Jones CM, Baldwin GT. Relationship between nonmedical prescription-opioid use and heroin use. N Engl J Med. 2016;374(2):154–63.
Casati A, Sedefov R, Pfeiffer-Gerschel T. Misuse of medicines in the European Union: a systematic review of the literature. Eur Addict Res. 2012;18(5):228–45.
Leong M, Murnion B, Haber PS. Examination of opioid prescribing in Australia from 1992 to 2007. Intern Med J. 2009;39(10):676–81.
Reissner V, Kokkevi A, Schifano F, Room R, Storbjörk J, Stohler R, et al. Differences in drug consumption, comorbidity and health service use of opioid addicts across six European urban regions (TREAT-project). Eur Psychiatry. 2012;27(6):455–62.
Myers B, Siegfried N, Parry CD. Over-the-counter and prescription medicine misuse in Cape Town--findings from specialist treatment centres. S Afr Med J. 2003;93(5):367–70.
Blanch B, Pearson SA, Haber PS. An overview of the patterns of prescription opioid use, costs and related harms in Australia. Br J Clin Pharmacol. 2014;78(5):1159–66.
Center for Behavioral Health Statistics and Quality. 2014 national survey on drug use and health: detailed tables. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2015.
Centers for Disease Control and Prevention. Heroin overdose data [internet]. Atlanta: US Department of Health and Human Services; 2017 [cited July 13th, 2018]. Available at: https://www.cdc.gov/drugoverdose/data/heroin.html.
Grau LE, Dasgupta N, Harvey AP, Irwin K, Givens A, Kinzly ML, et al. Illicit use of opioids: is OxyContin a “gateway drug”? Am J Addict. 2007;16(3):166–73.
Siegal HA, Carlson RG, Kenne DR, Swora MG. Probable relationship between opioid abuse and heroin use. Am Fam Physician. 2003;67(5(5):942.
Lankenau SE, Teti M, Silva K, Jackson Bloom J, Harocopos A, Treese M. Initiation into prescription opioid misuse amongst young injection drug users. Int J Drug Policy. 2012;23(1):37–44.
Pollini RA, Banta-Green CJ, Cuevas-Mota J, Metzner M, Teshale E, Garfein RS. Problematic use of prescription-type opioids prior to heroin use among young heroin injectors. Subst Abuse Rehabil. 2011;2(1):173–80.
Mars SG, Bourgois P, Karandinos G, Montero F, Ciccarone D. “Every ‘never’ I ever said came true”: transitions from opioid pills to heroin injecting. Int J Drug Policy. 2014;25(2):257–66.
Cicero TJ, Ellis MS, Surratt HL, Kurtz SP. The changing face of heroin use in the United States: a retrospective analysis of the past 50 years. JAMA Psychiatry. 2014;71(7):821–6.
Vital signs: demographic and substance use trends among heroin users — United States, 2002–2013. MMWR Morb Mortal Wkly Rep. 2015;64:719–25.
Muhuri PK, Gfroerer JC, Davies C. Associations of nonmedical pain reliever use and initiation of heroin use in the United States. CBHSQ Data Review, 2013. Available at: https://www.samhsa.gov/data/sites/default/files/DR006/DR006/nonmedical-pain-reliever-use-2013.htm.
Jones CM. Heroin use and heroin use risk behaviors among nonmedical users of prescription opioid pain relievers - United States, 2002-2004 and 2008-2010. Drug Alcohol Depend. 2013;132(1–2):95–100.
Jones CM, Einstein EB, Compton WM. Changes in synthetic opioid involvement in drug overdose deaths in the United States, 2010 – 2016. JAMA. 2018;319(17):1819–21.
European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2017: Trends and developments. Luxembourg: Publ Off Euor Union, 2017. p. 96. ISBN: 978-92-9497-095-4, ISSN: 2314-086, doi: https://doi.org/10.2810/610791. Available at: http://www.emcdda.europa.eu/system/files/publications/4541/TDAT17001ENN.pdf.
Funding
SN is supported by the Michael Smith Foundation for Health Research (MSFHR). MES is supported by the MSFHR and the St. Paul’s Foundation. EW is supported by the Canada Research Chairs Program through a Tier 1 Canada Research Chair and the Canadian Institutes of Health Research (SMN-139148).
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This article is part of the Topical Collection on Opioids
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Nolan, S., Socias, M.E. & Wood, E. The Threat of an International Opioid Crisis. Curr Addict Rep 5, 473–477 (2018). https://doi.org/10.1007/s40429-018-0231-x
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DOI: https://doi.org/10.1007/s40429-018-0231-x