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Early Renal Abnormalities as an Indicator of Cardiovascular Risk in Type 2 Diabetes

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Abstract

Accurate assessment of cardiovascular (CV) risk is a prerequisite for devising effective therapeutic strategies in patients with type 2 diabetes (T2DM) as it allows to refine prognosis and treatment targets as well as the cost-benefit ratio for specific pharmacological interventions. The presence of subclinical vascular organ damage plays a well known role in determining overall risk and a wider use of low cost, easy to perform diagnostic tools to stratify CV risk is very much needed. Besides their well known prognostic value for progression to end stage renal disease (ESRD), subclinical renal abnormalities such as microalbuminuria and/or a slight reduction in estimation of glomerular filtration rate (eGFR), have been shown to be powerful, independent predictors of CV diseases in patients with T2DM. Through the combined evaluation of these two biomarkers of chronic kidney disease (CKD), clinicians can usefully and reliably get a perspective on global and CV outcome of their diabetic patients.

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Acknowledgments

This work was supported by Grants from the Italian Ministero della Salute (Bando Giovane Ricercatore 2008, CUP G35J11000130001).

Disclosure

The authors declare that there is no conflict of interests regarding the publication of this paper.

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Authors and Affiliations

  1. Università degli Studi and I.R.C.C.S. Azienda Ospedaliera Universitaria San Martino-IST, Viale Benedetto XV, 16125, Genoa, Italy

    Francesca Viazzi, Barbara Bonino, Elena Ratto & Roberto Pontremoli

  2. Unit of Internal Medicine, Scientific Institute, San Giovanni Rotondo, Italy

    Salvatore De Cosmo

Authors
  1. Francesca Viazzi
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  2. Barbara Bonino
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  3. Elena Ratto
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  4. Salvatore De Cosmo
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  5. Roberto Pontremoli
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Corresponding author

Correspondence to Roberto Pontremoli.

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Viazzi, F., Bonino, B., Ratto, E. et al. Early Renal Abnormalities as an Indicator of Cardiovascular Risk in Type 2 Diabetes. High Blood Press Cardiovasc Prev 21, 257–260 (2014). https://doi.org/10.1007/s40292-014-0067-y

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  • DOI: https://doi.org/10.1007/s40292-014-0067-y

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