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Hypertensive Heart Disease and Obesity: A Complex Interaction Between Hemodynamic and Not Hemodynamic Factors

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Abstract

The worldwide prevalence of obesity has nearly doubled, with an increase in obesity-related cardiovascular disease and mortality. Several factors are involved in the genesis of hypertension and hypertensive heart disease (HHD) in overweight/obesity. This review is focused on bridging factors between excessive adiposity and HHD, presenting a unifying hypothesis of vascular–metabolic syndrome, where an “handicap” of the natriuretic peptide system has a central role both in adipocyte dysmetabolism as well as in increased blood pressure and HHD.

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Authors and Affiliations

  1. Internal Medicine and Geriatrics, “Hypertension Excellence Centre” of the European Society of Hypertension, Department of Clinical and Molecular Sciences, University “Politecnica delle Marche”, Italian National Research Centre on Aging “U. Sestilli”, IRCCS-INRCA, via della Montagnola n. 81, 60127, Ancona, Italy

    Riccardo Sarzani, Marica Bordicchia, Francesco Spannella, Paolo Dessì-Fulgheri & Massimiliano Fedecostante

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  1. Riccardo Sarzani
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  2. Marica Bordicchia
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  3. Francesco Spannella
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Correspondence to Riccardo Sarzani.

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Sarzani, R., Bordicchia, M., Spannella, F. et al. Hypertensive Heart Disease and Obesity: A Complex Interaction Between Hemodynamic and Not Hemodynamic Factors. High Blood Press Cardiovasc Prev 21, 81–87 (2014). https://doi.org/10.1007/s40292-014-0054-3

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