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Genetic Markers for Cardiovascular Disease in Psoriasis: The Missing Piece

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Abstract

Psoriasis is a common, chronic inflammatory disease associated with serious comorbidities. Severe psoriasis has been associated with increase cardiovascular mortality, due to a higher prevalence of traditional cardiovascular risk factors such as diabetes, hypertension, dyslipidemia and obesity, and premature atherosclerosis, as a consequence of its systemic inflammation. It is likely that there are genetic links between psoriasis, its comorbidities and cardiovascular disease. Although there are some studies performed in rheumatoid arthritis reporting some gene polymorphisms that may be associated with cardiovascular diseases and comorbidities these studies are lacking in psoriasis. Recognizing genetic markers that could predict which patients are at risk of developing psoriasis-linked cardiovascular comorbidities would facilitate screening strategies and permit an earlier management of cardiovascular risk factors, with important clinical implications.

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No sources of funding were used to prepare this manuscript.

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The authors have no conflicts of interest that are directly relevant to the content of this manuscript.

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Authors and Affiliations

  1. Serviço de Dermatologia, Centro Hospitalar do Porto, Edifício das Consultas Externas, Ex-CICAP, Rua D. Manuel II, s/n, 4100, Porto, Portugal

    Tiago Torres

  2. Instituto Ciências Abel Salazar, University of Porto, Porto, Portugal

    Tiago Torres

  3. Department of Dermatology, University of Rome Tor Vergata, Rome, Italy

    Andrea Chiricozzi, Sergio Chimenti & Rosita Saraceno

Authors
  1. Tiago Torres
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  2. Andrea Chiricozzi
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  3. Sergio Chimenti
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  4. Rosita Saraceno
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Correspondence to Tiago Torres.

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Torres, T., Chiricozzi, A., Chimenti, S. et al. Genetic Markers for Cardiovascular Disease in Psoriasis: The Missing Piece. Mol Diagn Ther 18, 93–95 (2014). https://doi.org/10.1007/s40291-013-0056-1

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  • DOI: https://doi.org/10.1007/s40291-013-0056-1

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