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Inflammation, Atherosclerosis, and Psoriasis

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Abstract

Increasing evidence supports an important role for inflammation in all phases of atherosclerosis, from initiation of the fatty streak to final culmination in acute coronary syndromes. Numerous inflammatory biomarkers including cell adhesion molecules, cytokines, chemokines, and acute-phase reactants such as fibrinogen, serum amyloid A, and C-reactive protein (CRP) have been shown to predict cardiovascular (CVD) events. Several prospective studies have shown a consistent and robust relationship between levels of high-sensitivity CRP and the risk of future CVD events. Toll-like receptors are pattern recognition receptors and members of the innate immune system that contribute to inflammation and appear to play key roles in atherosclerosis. Lipoprotein-associated phospholipase A2 may also be an independent CVD risk factor. Psoriasis has been associated with an increasing risk for atherosclerosis, including coronary artery disease and stroke. Patients with psoriasis have a 5-year shorter life expectancy, most frequently due to CVD. Psoriasis is associated with a chronic inflammatory state and with elevated levels of CRP and other inflammatory cytokines and these may play a causative role in the increased risk of psoriatic patients for CVD. Patients with psoriasis may represent an emerging risk population and patients with moderate to severe psoriasis should be screened and aggressively treated for CVD risk factors.

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Acknowledgment

The authors gratefully acknowledge the assistance of Richard Cacciato MLIS, Medical Librarian, VA Northern California Health Care System, for his support in retrieving articles and of Ms. Susan Edwards who provided expert secretarial assistance.

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  1. Medical Service, Department of Veterans Affairs, Northern California Health Care System, Mather, CA, USA

    David Siegel, Anupam Mitra, Siba P. Raychaudhuri, Smriti K. Raychaudhuri & Ishwarlal Jialal

  2. Department of Medicine, School of Medicine, University of California, Davis and The Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA, USA

    David Siegel, Sridevi Devaraj, Siba P. Raychaudhuri & Ishwarlal Jialal

  3. Department of Veterans Affairs NCHCS, Medical Service (111), 10535 Hospital Way, Mather, CA, 95655, USA

    David Siegel

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Siegel, D., Devaraj, S., Mitra, A. et al. Inflammation, Atherosclerosis, and Psoriasis. Clinic Rev Allerg Immunol 44, 194–204 (2013). https://doi.org/10.1007/s12016-012-8308-0

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