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The Times They Are A-Changin’: New Antibacterials for Skin and Skin Structure Infections

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Abstract

Twenty-one agents are approved by the US Food and Drug Administration (FDA) for the therapy of skin and soft tissue infections. Of these, the five newest agents, tedizolid, telavancin, oritavancin, dalbavancin, and ceftaroline, are active against and “non-inferior” to vancomycin against methicillin-resistant Staphylococcus aureus (MRSA). Oritavancin is indicated as a single-dose intravenous regimen, while dalbavancin is a two-dose intravenous regimen given 1 week apart. Telavancin has multiple mechanisms of action. A 6-day regimen of once-daily intravenous or oral dose of tedizolid was compared with 10 days of linezolid and found to be “non-inferior” and have fewer side effects. Ceftaroline has not only MRSA activity but also activity against Escherichia coli and Klebsiella spp. We review the spectra of activity of these new agents, their clinical trials and their therapeutic efficacy, noting differences in their dosing schedules, in vitro activities and costs as potential determinants for appropriate utilization.

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Conflict of interest

MC N Tran has no conflict of interest to declare.

S Naumovski has no conflict of interest to declare.

EJC Goldstein is on Advisory Boards for Merck, Bio K+, Bayer, Summit corp plc, Kindred Healthcare corp, Novartis, Sankyo-Daichi, Rempex. He is on the speaker bureau for Bayer Inc, Merck & Co, Forest Pharmaceuticals, Cubist. He has received research grants from Merck, Optimer, GSK, Cubist, Cerexa and Forrest Pharmaceuticals, Cerexa, Impex Pharmaceuticals, Novartis, Clinical Microbiology Institute, Genzyme, Nanopacific Holding Inc, Romark Laboratories LC, Viroxi Corp, Avidbiotics Corp, GLSynthesis Inc, Immunome Inc, Toltec Pharma LLC, Salix, Summit Corp plc, Rempex Pharmaceuticals, Symbiomix Therapeutics, Amicrobe Inc, Durata, Gynuity Heralth Project.

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Authors and Affiliations

  1. Department of Pharmacy, Providence Saint John’s Health Center, 2121 Santa Monica Blvd, Santa Monica, CA, 90404, USA

    Mai-Chi N. Tran & Snezana Naumovski

  2. Clinica Juan Pablo Medical Group, Los Angeles, CA, 90023, USA

    Mai-Chi N. Tran

  3. Infectious Diseases Division, Providence Saint John’s Health Center, 2121 Santa Monica Blvd, Santa Monica, CA, 90404, USA

    Ellie J. C. Goldstein

  4. RM Alden Research Laboratory, Santa Monica, CA, 90404, USA

    Ellie J. C. Goldstein

  5. David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA

    Ellie J. C. Goldstein

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  1. Mai-Chi N. Tran
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Tran, MC.N., Naumovski, S. & Goldstein, E.J.C. The Times They Are A-Changin’: New Antibacterials for Skin and Skin Structure Infections. Am J Clin Dermatol 16, 137–146 (2015). https://doi.org/10.1007/s40257-015-0125-9

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