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Programmable Assembly of DNA-protein Hybrid Structures

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Chemical Research in Chinese Universities Aims and scope

Abstract

DNA is the genetic information carrier for most known living organisms on Earth, while proteins are the functional component that carry out most biological processes. Many natural machineries are DNA-protein hybrid complexes to cooperatively and efficiently conduct sophisticated biological tasks. It has drawn increasing interest to the research field to construct artificial DNA-protein hybrid structures towards a variety of applications including biological studies, nanofabrication, biomedical research, etc. In this regard, here in this report we reviewed the up-to-date progress on making DNA-protein hybrid structures, with a particular focus on DNA nanotechnology-enabled programmable assembly of DNA-protein hybrid structures.

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Authors and Affiliations

  1. Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China

    Xue Li, Donglei Yang, Luyao Shen, Fan Xu & Pengfei Wang

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  1. Xue Li
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  2. Donglei Yang
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  3. Luyao Shen
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  4. Fan Xu
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  5. Pengfei Wang
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Correspondence to Pengfei Wang.

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Supported by the National Natural Science Foundation of China (No. 21974086).

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Li, X., Yang, D., Shen, L. et al. Programmable Assembly of DNA-protein Hybrid Structures. Chem. Res. Chin. Univ. 36, 211–218 (2020). https://doi.org/10.1007/s40242-019-0038-x

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