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Gelatin-based instant gel-forming volatile spray for wound-dressing application

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Abstract

This study was a successful endeavor to develop and investigate the suitability of a bioadhesive wound-healing gel based on gelatin for first-aid purposes. Polyethylene glycol (PEG) was used to prepare a denser phase of gelatin chains, and diethyl ether (DEE) was used to introduce high volatility to the solution. The prepared solution was stable in the storage container but rapidly formed (within 3 s) a protective and bioadhesive gel around the wound surface by being sprayed over the wound. Besides, it also suppressed pain and showed moderate antimicrobial activity against S. aureus. It was also found highly biocompatible and non-toxic. All the results revealed that the prepared solution could be an effective candidate for treating minor injuries or burn, especially for a first-aid purpose.

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Author notes

  1. Mohammed Shahidul Islam and Jahid M. M. Islam equally contributed.

Authors and Affiliations

  1. Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Savar, Dhaka, 1349, Bangladesh

    Mohammed Shahidul Islam, Jahid M. M. Islam, M Fizur Rahman & Mubarak A. Khan

  2. School of Science, Monash University Malaysia, 47500, Subang Jaya, Selangor, Malaysia

    Jahid M. M. Islam

  3. Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, 2000, Bangladesh

    Mohammed Shahidul Islam & Mohammed Mizanur Rahman

  4. Department of Chemistry and Biochemistry, Texas Tech University, 1204 Boston Avenue, Lubbock, TX, 79409, USA

    Mohammed Shahidul Islam

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  1. Mohammed Shahidul Islam
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  2. Jahid M. M. Islam
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  3. M Fizur Rahman
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  4. Mohammed Mizanur Rahman
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  5. Mubarak A. Khan
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Correspondence to Mubarak A. Khan.

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Islam, M.S., Islam, J.M.M., Rahman, M.F. et al. Gelatin-based instant gel-forming volatile spray for wound-dressing application. Prog Biomater 10, 235–243 (2021). https://doi.org/10.1007/s40204-021-00166-3

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  • DOI: https://doi.org/10.1007/s40204-021-00166-3

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