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Evaluation of fluorohydroxyapatite/strontium coating on titanium implants fabricated by hydrothermal treatment

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Abstract

Titanium and its alloys are considered as appropriate replacements for the irreparable bone. Calcium phosphate coatings are widely used to improve the osteoinduction and osseointegration ability of titanium alloys. To further improve the performance of the calcium phosphate-coated implants, strontium (Sr) was introduced to partially replace the calcium ions. In this study, the effect of Sr ion addition on the fluorohydroxyapatite (FHA)-coated Ti6Al4V alloy was investigated and all the coatings were treated under hydrothermal condition. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to investigate the phases and microstructures, respectively. Shear tests were done to evaluate the bond strength of the coating layer. MTT, adhesion, and alkaline phosphatase tests were performed to evaluate the biocompatibility and osteogenic behavior of the samples. Results showed that the average crystallite size for the strontium-doped FHA samples was 48 nm and the bond strength had increased 13.15% in comparison with FHA-coated samples. Analysis of variance showed p value for all MTT tests at more than 0.322 and there was not any evidence of cell death after 7 days. The results of the ALP test showed that the increase of the cell activity in Sr samples from day 7 to 14 is three times higher than the FHA ones.

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Abbreviations

FHA:

Fluorohydroxyapatite

FHA–Sr:

Fluorohydroxyapatite/strontium

FA:

Fluorapatite

Sr:

Strontium

MAA:

Micro-arc anodizing

XRD:

X-ray diffraction

SEM:

Scanning electron microscopy

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Acknowledgements

The authors thank the materials research group of the Iranian Academic Center for Education, Culture, and Research (ACECR) for the financial and scientific support of this research.

Funding

This work was supported by ACECR Mashhad branch, Iran.

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Authors and Affiliations

  1. Materials Research Group, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, P.O. Box 91779-49367, Mashhad, Iran

    Ahmad Moloodi & Akram Salehi

  2. Sadjad University of Technology, P.O. Box 91881-48848, Mashhad, Iran

    Haniyeh Toraby, Saeed Kahrobaee & Morteza Kafaie Razavi

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  1. Ahmad Moloodi
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  2. Haniyeh Toraby
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  3. Saeed Kahrobaee
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  4. Morteza Kafaie Razavi
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Correspondence to Akram Salehi.

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Moloodi, A., Toraby, H., Kahrobaee, S. et al. Evaluation of fluorohydroxyapatite/strontium coating on titanium implants fabricated by hydrothermal treatment. Prog Biomater 10, 185–194 (2021). https://doi.org/10.1007/s40204-021-00162-7

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