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Short-term circuit resistance training improves insulin resistance probably via increasing circulating Adropin

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Abstract

Aim and background

The underlying mechanism of exercise-induced insulin resistance (IR) improvement is unclear. Adropin is a multifunctional peptide has a significant role in the regulation of physical activity and insulin sensitivity. Thus, the aim of this study was to evaluate the effects of various circuit resistance (CRT) intensities on circulating adropin levels and IR and their relation.

Method

Forty-five voluntarily male men randomly were divided into 5 groups; control and 4 groups of CRT (20%, 40%, 60% and 80% of one-repetition maximum (1-RM)). Training groups performed CRT protocol 3 times a week for 6 weeks. Blood samples were drawn before and 48 h after the last training session and used for analyzing serum levels of adropin, glucose and insulin.

Results

The results showed that varying CRT intensities were associated with adropin elevation in comparison to the control group. Further analysis revealed that plasma adropin is higher in the 20% 1-RM group compared to the 40% 1-RM group. Furthermore, fasting insulin and glucose, as well as IR, were decreased in response to different CRT intensities. In addition, these reductions were significantly correlated with adropin level.

Conclusion

It can be speculated that different CRT intensities improve IR probably via increasing adropin level, and should be considered as an effective training method for diminishing glucose metabolism disorders.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors would like to thank all the participants who gave us their time and participated in this trial.

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Authors and Affiliations

  1. Department of Sports Science, School of Literature and Humanities, Ilam University, Ilam, I.R, Iran

    Najmeh Rezaeinezhad & Rostam Alizadeh

  2. Department of Exercise Biochemistry Division, Faculty of Sport Sciences, University of Mazandaran, Babolsar, I.R, Iran

    Abbas Ghanbari-Niaki

Authors
  1. Najmeh Rezaeinezhad
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  2. Rostam Alizadeh
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Correspondence to Rostam Alizadeh.

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Rezaeinezhad, N., Alizadeh, R. & Ghanbari-Niaki, A. Short-term circuit resistance training improves insulin resistance probably via increasing circulating Adropin. J Diabetes Metab Disord 21, 583–588 (2022). https://doi.org/10.1007/s40200-022-01020-4

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  • DOI: https://doi.org/10.1007/s40200-022-01020-4

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