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A Bayesian analysis for investigating the association between rs13266634 polymorphism in SLC30A8 gene and type 2 diabetes

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Abstract

Purpose

The purpose of this study was to evaluate the association between rs13266634 polymorphism in SLC30A8 gene and type 2 diabetes in Iranian population, and also to provide a way for adjusting the deviation from the Hardy-Weinberg equilibrium.

Methods

This was a case-control study, the patients were selected from the East Azerbaijan province, Iran. In this study, 125 patients with type 2 diabetes (cases) and 125 healthy individuals (controls) were studied. Genotype and allele frequencies were determined in both groups, and the deviations from the Hardy-Weinberg equilibrium were assessed using Bayesian analysis.

Results

A statistically significant association was observed between rs13266634 polymorphism in SLC30A8 gene and type 2 diabetes. In genotype assessing, data analysis showed that, TT genotype play a role in diabetes type 2 risk (P = 0.001). Subjects with TT genotype had a lower risk of diabetes compared to those with CC and CT genotypes. Also, there was no significant relationship between this polymorphism and type 2 diabetes mellitus in the absence of Hardy-Weinberg equilibrium.

Conclusion

Our findings show that, rs13266634 polymorphism was associated with the type 2 diabetes risk in the population of Eastern Azerbaijan province; however, the low number of TT homozygous genotypes affected the precision of the results. Also, the deviation from HWE affected the results. It is recommended to perform further studies to establish Hardy-Weinberg equilibrium. The inconsistency in the results may be due to the ignorance of this equilibrium.

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Acknowledgements

This work was supported by a fund from Hamadan University of Medical Sciences (Contract No. 9609286037). This work is a part of the results of the PhD thesis of Mr. Ghaffari, the corresponding author of this paper, supervised by Professor Soltanian, the paper’s first author.

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Authors and Affiliations

  1. Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

    Ali Reza Soltanian, Hossein Mahjub & Mohammad Ebrahim Ghaffari

  2. Research Center for Health Sciences, School of Public Health and, Hamadan University of Medical Sciences, Hamadan, Iran

    Ali Reza Soltanian & Hossein Mahjub

  3. Kermanshah Province Electricity Distribution Company, Kermanshah, Iran

    Bistoon Hosseini

  4. Department of Molecular Medicine and Genetics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Fatemeh Bahreini

Authors
  1. Ali Reza Soltanian
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  2. Bistoon Hosseini
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  3. Hossein Mahjub
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  4. Fatemeh Bahreini
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  5. Mohammad Ebrahim Ghaffari
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Contributions

Ali Reza Soltanian, Bistoon Hosseini, and Mohammad Ebrahim Ghaffari analyzed the data and drafted the manuscript. Ali Reza Soltanian, Fatemeh Bahreini, and Mohammad Ebrahim Ghaffari designed the study and directed the implementation. Hossein Mahjub and Fatemeh Bahreini edited the manuscript for intellectual content and provided critical comment on the manuscript.

Corresponding author

Correspondence to Mohammad Ebrahim Ghaffari.

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Conflict of interest

The authors declare no conflict of interest.

Ethical approval

This study was approved by the Ethical committee, Hamadan University of Medical Sciences. The written informed consents were obtained from all the participants before conducting the study.

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Soltanian, A.R., Hosseini, B., Mahjub, H. et al. A Bayesian analysis for investigating the association between rs13266634 polymorphism in SLC30A8 gene and type 2 diabetes. J Diabetes Metab Disord 19, 337–342 (2020). https://doi.org/10.1007/s40200-020-00514-3

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  • DOI: https://doi.org/10.1007/s40200-020-00514-3

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