Skip to main content

Advertisement

Log in

Recent developments in cancer therapy and diagnosis

  • Review
  • Published:
Journal of Pharmaceutical Investigation Aims and scope Submit manuscript

Abstract

Background

The cancer is serious health problem and leading cause of death in the world.

Area covered

There have intensively studied for diagnosis and therapy of this disease and these studies provided important insights into their mechanism of action and therapeutic/diagnostic effects. The accurence rates of cancer has dramatic increase, particularly in the developed countries. Although there are many different strategies about diagnosis and treatment for cancer, more effective new approaches are needed.

Expert opinion

In this review, we summarize recent developments on cancer diagnosis, radiopharmaceuticals in cancer diagnosis, nanoparticulate systems in cancer diagnosis, T cells in cancer diagnosis, cancer therapy and pharmacokinetic of anticancer drugs. We thought that while there are some current limitations such as clinical studies, ranging from diagnosis to theraphy, future improvements in cancer diagnosis and treatment will meet the most relevant issues required for the eventual approval of nano-drugs, radiopharmaceuticals, T cells in clinical practice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Ahearne MJ, Bhuller K, Hew R, Ibrahim H, Naresh K, Wagner SD (2014) Expression of PD-1 (CD279) and FoxP3 in diffuse large B-cell lymphoma. Virchows Arch 465(3):351–358

    CAS  PubMed  Google Scholar 

  • Al-Saeedi F (2002) Role of 99mTc-(V)DMSA in detecting tumor cell proliferation. Anal Chem Insights 2:81–83

    Google Scholar 

  • Arnold PY, Davidian DK, Mannie MD (1997) Antigen presentation by T cells: T cell receptor ligation promotes antigen acquisition from professional antigen-presenting cells. Eur J Immunol 27(12):3198–3205

    CAS  PubMed  Google Scholar 

  • Berger R, Rotem-Yehudar R, Slama G, Landes S, Kneller A, Leiba M, Koren-Michowitz M et al (2008) Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res 14(10):3044–3051

    CAS  PubMed  Google Scholar 

  • Boyle P, Levin B (2008) World Cancer Report 2018. IARC Press, International Agency for Research on Cancer. World Health Organization, Lyon, p 510

    Google Scholar 

  • Brigger I, Dubernet C, Couvreur P (2002) Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 54(5):631–651

    CAS  PubMed  Google Scholar 

  • Cegnar M, Premzl A, Zavasnik-Bergant V, Kristl J, Kos J (2004) Poly(lactide-co-glycolide) nanoparticles as a carrier system for delivering cysteine protease inhibitor cystatin into tumor cells. Exp Cell Res 301(2):223–231

    CAS  PubMed  Google Scholar 

  • Chakravarty R, Hong H, Cai W (2014) Positron emission tomography image-guided drug delivery: current status and future perspectives. Mol Pharm 11(11):3777–3797

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chakravarty R, Hong H, Cai W (2015) Image-guided drug delivery with single-photon emission computed tomography: a review of literature. Curr Drug Targets 16(6):592–609

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chernov VI, Triss SV, Skuridin VS, Lishmanov YB (1996) Thallium-199: a new radiopharmaceutical for myocardial perfusion imaging. Int J Cardiac Imaging 12(2):119–126

    CAS  Google Scholar 

  • Chernov V, Rogov A, Skuridin V, Stasyuk E, Nestrow E, Varlamova N, Zelchan R et al (2015) Eur J Nucl Med Mol Imaging 42(1):498

    Google Scholar 

  • Chernov V, Bragina O, Sinilkin I, Medvedeva A, Zelchan R (2016) Vestnik Rentgenologii Radiologii 97(5):306–313

    CAS  Google Scholar 

  • Chiriva-Internati M, Grizzi F, Pinkston J, Morrow KJ, D'Cunha N, Frezza EE, Muzzio PC et al (2006) Gamma-radiation upregulates MHC class I/II and ICAM-I molecules in multiple myeloma cell lines and primary tumors. Vitro Cell Dev Biol Anim 42(3–4):89–95

    CAS  Google Scholar 

  • De Charette M, Marabelle A, Houot R (2016) Turning tumour cells into antigen presenting cells: the next step to improve cancer immunotherapy? Eur J Cancer 68:134–147

    PubMed  Google Scholar 

  • Destito G, Yeh R, Rae CS, Finn MG, Manchester M (2007) Folic acid-mediated targeting of cowpea mosaic virus particles to tumor cells. Chem Biol 14(10):1152–1162

    CAS  PubMed  PubMed Central  Google Scholar 

  • Disis ML, Wallace DR, Gooley TA, Dang Y, Slota M, Lu H, Coveler AL et al (2009) Concurrent trastuzumab and HER2/neu-specific vaccination in patients with metastatic breast cancer. J Clin Oncol 27(28):4685–4692

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dominguez-Gil Hurle A. (2006) Farmacocinética de los medicamentos obtenidos por biotecnología. In: Bueren J, Motellon JL (eds.). Curso de Biotecnología Aplicada. 6th edn. CIEMAT, Madrid; pp 121–34. https://www.sefh.es/bibliotecavirtual/biotecnologia/10farmacocinetica.pdf

  • D'Souza MM, Sharma R, Tripathi M, Panwar P, Jaimini A, Mondal A (2011) Novel positron emission tomography radiotracers in brain tumor imaging. Indian J Radiol Imaging 21(3):202–208

    PubMed  PubMed Central  Google Scholar 

  • Garattini S (2007) Pharmacokinetics in cancer chemotherapy. Eur J Cancer 43(2):271–282

    CAS  PubMed  Google Scholar 

  • Good Practice for Introducing Radiopharmaceuticals for Clinical Use IAEA TECDOC IAEA-TECDOC (1782).

  • Griesser H, Mak TW (1994) The T-cell receptor–structure, function, and clinical application. Hematol Pathol 8(1–2):1–23

    CAS  PubMed  Google Scholar 

  • Hadrup S, Donia M, Thor SP (2013) Effector CD4 and CD8 T cells and their role in the tumor microenvironment. Cancer Microenviron 6(2):123–133

    CAS  PubMed  Google Scholar 

  • Hare JI, Lammers T, Ashford MB, Puri S, Storm G, Barry ST (2017) Challenges and strategies in anti-cancer nanomedicine development: an industry perspective. Adv Drug Deliv Rev 108:25–38

    CAS  PubMed  Google Scholar 

  • Herrmann F, Lehr HA, Drexler I, Sutter G, Hengstler J, Wollscheid U, Seliger B (2004) HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway. Cancer Res 64(1):215–220

    CAS  PubMed  Google Scholar 

  • Inoue M, Mimura K, Izawa S, Shiraishi K, Inoue A, Shiba S, Watanabe M et al (2012) Expression of MHC Class I on breast cancer cells correlates inversely with HER2 expression. Oncoimmunology 1(7):1104–1110

    PubMed  PubMed Central  Google Scholar 

  • Kim MS, Hwang SJ, Han JK, Choi EK, Park HJ, Kim JS, Lee DS (2006) pH-responsive PEG-poly (b-amino ester) block copolymer micelles with a sharp transition. Macromol Rapid Commun 27(6):447–451

    CAS  Google Scholar 

  • Kundu M, Sadhukhan P, Ghosh N, Chatterjee S, Manna P, Parames C (2019) pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy. J Adv Res 13:24–67

    Google Scholar 

  • Kunjachan S, Ehling J, Storm G, Kiessling F, Lammers T (2015) Noninvasive imaging of nanomedicines and nanotheranostics: principles, progress, and prospects. Chem Rev 115(19):10907–10937

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lakna P. (2017) Difference between humoral and cell mediated immunity. Human Anat. https://pediaa.com/difference-between-humoral-and-cell-mediated-immunity/

  • Lammers T, Kiessling F, Hennink WE, Storm G (2010) Nanotheranostics and image-guided drug delivery: current concepts and future directions. Mol Pharm 7(6):1899–1912

    CAS  PubMed  Google Scholar 

  • Lammers T, Rizzo LY, Storm G, Kiessling F (2012) Personalized nanomedicine. Clin Cancer Res 18(18):4889–4894

    CAS  PubMed  Google Scholar 

  • Lanza GM, Moonen C, Baker JR Jr, Chang E, Cheng Z, Grodzinski P, Ferrara K et al (2014) Assessing the barriers to image-guided drug delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol 6(1):1–14

    CAS  PubMed  Google Scholar 

  • Lee H, Lee E, Kim DK, Jang NK, Jeong YY, Jon S (2006) Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging. J Am Chem Soc 128(22):7383–7389

    CAS  PubMed  Google Scholar 

  • Lesokhin AM, Ansell SM, Armand P, Scott EC, Halwani A, Gutierrez M, Millenson MM et al (2014) Preliminary results of a phase I study of nivolumab (BMS-936558) in patients with relapsed or refractory lymphoid malignancies. Blood 124(21):291

    Google Scholar 

  • Liebmann JE et al (1993) Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines. Br J Cancer 68:1104–1109

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lishmanov IuB, Chernov VI, Krivonogov NG, Glukhov GG, Maslova LV (1988) Experimental perfusion scintigraphy of the myocardium using Tl-199 chloride. Med Radiol (Mosk) 33(3):13–16

    Google Scholar 

  • Liu D, Huang X, Wang Z, Jin A, Sun X, Zhu L (2013) Gold nanoparticle-based activatable probe for sensing ultralow levels of prostatespecific antigen. ACS Nano 7:5568–5576

    CAS  PubMed  PubMed Central  Google Scholar 

  • Liu Y, Li LL, Qi GB, Chen XG, Wang H (2014) Dynamic disordering of liposomal cocktails and the spatio-temporal favorable release of cargoes to circumvent drug resistance. Biomaterials 35:3406–3415

    CAS  PubMed  Google Scholar 

  • Lugade AA, Sorensen EW, Gerber SA, Moran JP, Frelinger JG, Lord EM (2008) Radiation-induced IFN- production within the tumor microenvironment influences antitumor immunity. J Immunol 180(5):3132–3139

    CAS  PubMed  Google Scholar 

  • MacFarlane AW, Jillab M, Plimack ER, Hudes GR, Uzzo RG, Litwin S, Dulaimi E et al (2014) PD-1 expression on peripheral blood cells increases with stage in renal cell carcinoma patients and is rapidly reduced after surgical tumor resection. Cancer Immunol Res 2(4):320–331

    CAS  PubMed  Google Scholar 

  • Maruyama T, Mimura K, Sato E, Watanabe M, Mizukami Y, Kawaguchi Y, Ando T et al (2010) Inverse correlation of HER2 with MHC class I expression on oesophageal squamous cell carcinoma. Br J Cancer 103(4):552–559

    CAS  PubMed  PubMed Central  Google Scholar 

  • Masson E, Zamboni WC (1997) Pharmacokinetic optimisation of cancer chemotherapy. Effect Outcomes Clin Pharmacokinet 32(4):324–343

    CAS  PubMed  Google Scholar 

  • Miao Y, Figueroa SD, Fisher DR, Moore HA, Testa RF, Hoffman TJ, Quinn TP (2008) 203Pb-labeled alpha-melanocyte-stimulating hormone peptide as an imaging probe for melanoma detection. J Nucl Med 49(5):823–829

    CAS  PubMed  PubMed Central  Google Scholar 

  • Mimura K, Ando T, Poschke I, Mougiakakos D, Johansson CC, Ichikawa J, Okita R et al (2011) T cell recognition of HLA-A2 restricted tumor antigens is impaired by the oncogene HER2. Int J Cancer 128(2):390–401

    CAS  PubMed  Google Scholar 

  • Natfji AA, Ravishankar D, Osborn HMI, Greco F (2017) Parameters affecting the enhanced permeability and retention effect: the need for patient selection. J Pharm Sci 106(11):3179–3187

    CAS  PubMed  Google Scholar 

  • Nguyen KT (2011) Targeted nanoparticles for cancer therapy: promises and challenges. J Nanomed Nanotechnol 34:45–51

    Google Scholar 

  • Ojha T, Rizzo L, Storm G, Kiessling F, Lammers T (2015) Image-guided drug delivery: preclinical applications and clinical translation. Expert Opin Drug Deliv 12(8):1203–1207

    CAS  PubMed  Google Scholar 

  • Park K, Lee S, Kang E, Kim K, Choi K, Kwon IC (2009) New generation of multifunctional nanoparticles for cancer imaging and therapy. Adv Funct Mater 19(10):1553–1566

    CAS  Google Scholar 

  • Pathirana AA, Vinjamuri S, Byrne C, Ghaneh P, Vora J, Poston GJ (2001) (131)I-MIBG radionuclide therapy is safe and cost-effective in the control of symptoms of the carcinoid syndrome. Eur J Surg Oncol 27(4):404–408

    CAS  PubMed  Google Scholar 

  • Peoples GE, Holmes JP, Hueman MT, Mittendorf EA, Amin A, Khoo S, Dehqanzada ZA et al (2008) Combined clinical trial results of a HER2/neu (E75) vaccine for the prevention of recurrence in high-risk breast cancer patients: US Military Cancer Institute Clinical Trials Group Study I-01 and I-02. Clin Cancer Res 14(3):797–803

    CAS  PubMed  Google Scholar 

  • Podojil JR, Miller SD (2009) Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy. Immunol Rev 229(1):337–355

    CAS  PubMed  PubMed Central  Google Scholar 

  • Popovtzer R, Agrawal A, Kotov NA, Popovtzer A, Balter J, Carey TE, Kopelman R (2008) Targeted gold nanoparticles enable molecular CT imaging of cancer. Nano Lett 8(12):4593–4596

    CAS  PubMed  PubMed Central  Google Scholar 

  • Prabhakar U, Maeda H, Jain RK, Sevick-Muraca EM, Zamboni W, Farokhzad OC, Barry ST et al (2013) Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. Cancer Res 73(8):2412–2417

    CAS  PubMed  PubMed Central  Google Scholar 

  • Raymond E et al (1997) Effects of prolonged versus short-term exposure paclitaxel (Taxol) on human tumor colony-forming units. Anticancer Drugs 8:379–385

    CAS  PubMed  Google Scholar 

  • Ratain MJ, Plunkett WK Jr (2003) Principles of pharmacokinetics. In: Kufe DW, Pollock RE, Weichselbaum RR, Bast RC, Gansler TS, Holland JF et al (eds.). Holland-frei cancer medicine. 6th edn. Hamilton (ON): BC Decker. https://www.ncbi.nlm.nih.gov/books/NBK12815/

  • Reits EA, Hodge JW, Herberts CA, Groothuis TA, Chakraborty M, Wansley EK, Camphausen K et al (2006) Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med 203(5):1259–1271

    CAS  PubMed  PubMed Central  Google Scholar 

  • Rivadeneira DB, Delgoffe GM (2018) Antitumor T cell reconditioning: improving metabolic fitness for optimal cancer immunotherapy. Clin Cancer Res. https://doi.org/10.1158/1078-0432.CCR-17-0894

    Article  PubMed  PubMed Central  Google Scholar 

  • Rodichev A, Garbuzov P, Drozdovsky B, Krylov V, Guseva T, Davydov G, Parshin V et al (2009) Vestnik RONC im NN Blohina RAMN 20(2):19–20

    Google Scholar 

  • Rogov A, Skuridin V, Stasyuk E, Nesterov E, Ilina E, Sadkin V, Chernov V et al (2015) Clinical significance of sentinel lymph node detection in patients with invasive cervical cancer. Eur J Nucl Med Mol Imaging 42(1):856

    Google Scholar 

  • Sachdeva M, Fischl MA, Pahwa R, Sachdeva N, Pahwa S (2010) Immune exhaustion occurs concomitantly with immune activation and decrease in regulatory T cells in viremic chronically HIV-1-infected patients. J Acquir Immune Defic Syndr 54(5):447–454

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sharma A, Bode B, Studer G, Moch H, Okoniewski M, Knuth A, von Boehmer L et al (2013) Radiotherapy of human sarcoma promotes an intratumoral immune effector signature. Clin Cancer Res 19(17):4843–4853

    CAS  PubMed  Google Scholar 

  • Shiryaev SV, Odzharova AA, Orel NF, Podluzhny DV, Polyakov AN, Rabinovich EZ, Volkov RJ (2008) Med Radiol Radiat Saf 53(1):53–62

    Google Scholar 

  • Siqing F, Culotta K, Falchook G, Hong D, Myers A, Zhang Y, Naing A, Janku F, Hou M, Kurzrock R (2016) Pharmacokinetic evaluation of nanoparticle albumin-bound paclitaxel delivered via hepatic arterial infusion in patients with predominantly hepatic metastases. Cancer Chemother Pharmacol 77(2):357–364

    CAS  PubMed  Google Scholar 

  • Skuridin V, Stasyuk E, Bragina O, Usubov M, Chernov V, Larkina M, Zelchan R et al (2016) Eur J Nucl Med Mol Imaging 43(1):465

    Google Scholar 

  • Svensson M, Stockinger B, Wick MJ (1997) Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells. J Immunol 158(9):4229–4236

    CAS  PubMed  Google Scholar 

  • Tartis M. (2009) Nanotechnology in nuclear medicine. The University of New Mexico Health Sciences Center College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. Program No. 039-000-09-147-H04-P 3.0.

  • Toon S (1996) The relevance of pharmacokinetics in the development of biotechnology products. Eur J Drug Metab Pharmacokinet 21(2):93–103

    CAS  PubMed  Google Scholar 

  • Vasir JK, Labhasetwar V (2007) Biodegradable nanoparticles for cytosolic delivery of therapeutics. Adv Drug Deliv Rev 59(8):718–728

    CAS  PubMed  PubMed Central  Google Scholar 

  • Vural Uçmak G, Özer AY (2015) Nükleer Tıpta İlaç Taşıyıcı Sistemler ve Teranostik Kullanımları. Nucl Med Semin 2:109–119

    Google Scholar 

  • Wen CJ, Zhang LW, Al-Suwayeh SA, Yen TC, Fang JY (2012) Theranostic liposomes loaded with quantum dots and apomorphine for brain targeting and bioimaging. Int J Nanomed 7:1599–1611

    CAS  Google Scholar 

  • Wildiers H, Heeren P, Puts M, Topinkova E, Janssen-Heijnen ML, Extermann M, Falandry C et al (2014) International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol 32(24):2595–2603

    PubMed  PubMed Central  Google Scholar 

  • Xin Y, Yin M, Zhao L, Meng F, Luo L (2017) Recent progress on nanoparticle-based drug delivery systems for cancer therapy. Cancer Biol Med 14(3):228–241

    CAS  PubMed  PubMed Central  Google Scholar 

  • Yang W, Cheng Y, Xu T, Wang X, Wen LP (2009) Targeting cancer cells with biotin-dendrimer conjugates. Eur J Med Chem 44(2):862–868

    CAS  PubMed  Google Scholar 

  • Yingchoncharoen P, Kalinowski DS, Richardson DR, Barker EL (2016) Lipid-based drug delivery systems in cancer therapy: what is available and what is yet to come. Pharmacol Rev 68:3

    Google Scholar 

  • Yu MK, Park J, Jon S (2012) Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Theranostics 2(1):3–44

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zeltchan R, Chernov V, Medvedeva A, Sinilkin I, Stasyuk E, Rogov A, Il’ina E et al (2016a) Study of a glucose derivative labeled with technetium-99m as potential radiopharmaceutical for cancer. Eur J Nucl Med Mol Imaging 43(Suppl 1):466

    Google Scholar 

  • Zeltchan R, Medvedeva A, Sinilkin I, Bragina O, Chernov V, Stasyuk E, Rogov A et al (2016b) Experimental study of radiopharmaceuticals based on technetium-99m labeled derivative of glucose for tumor diagnosis. IOP Conf Mater Sci Eng 135:012054

    Google Scholar 

  • Zuo M, Shen H, Yin J, Wang W, Zhang Y, Zhou DB, Zhang W (2018) Expression of PD-1 on peripheral blood Treg cells is related to the diagnosis, prognosis and treatment of T cell non-Hodgkin lymphoma. Leuk Res 70:56–61

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Evren Atlihan-Gundogdu.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

This article does not contain any studies with human and animal subjects performed by any of the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Atlihan-Gundogdu, E., Ilem-Ozdemir, D., Ekinci, M. et al. Recent developments in cancer therapy and diagnosis. J. Pharm. Investig. 50, 349–361 (2020). https://doi.org/10.1007/s40005-020-00473-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40005-020-00473-0

Keywords

Navigation