Abstract
Earliest precise diagnosis and targeted therapy underlines the efficiency of successful cancer management. Conventional diagnostics are usually dependent on phenotypic expression of cancer signatures which often effects into delayed detection leading to poor prognosis. Traditional therapeutics frequently lacks precise targeting leading to sub-optimal drug concentration as well as off-target systemic side effects. Nano-intervention delivers in both the aspects: integration of advanced imaging modalities with site-specific targeting of nano-imaging agents can improve the sensitivity and specificity of cancer detection along with advent of diverse nanoparticle-based biosensors extends the scope for rapid and point-of-care diagnosis. Moreover, multifunctional nanoparticles facilitate simultaneous diagnosis and therapies of cancers in one go. Nanoparticle-based drug delivery systems with spatio-temporally controlled release mechanism facilitate targeted payload conveyance at the tumor sites with prolongs maintenance of adequate drug concentration to curtail general toxicity of the chemotherapeutics. Furthermore, it augments the pharmacokinetic properties of the drugs by improving the penetration, distribution and bioavailability of the therapeutic agents, even occasionally fortifying with synergistic effects. Premature drug release, fast enzymatic degradation, and rapid clearance can also be avoided by exploiting nano-encapsulation and stimuli-responsive nanoparticle-based drug delivery systems. Cancer immunotherapy has also gained significant attention in current scenario which mostly relies upon nanoparticle-based biological and vaccine delivery systems along with introduction of nano-adjuvants as component of nano-vaccines to enhance the immunogenicity and protection against cancers. Thus nanotechnology has the potential to empower the arsenal against cancer by diverse means; however, it faces some inherent challenges such as potential toxicity of nanomaterials, stringent regulatory issues delaying smooth and timely clinical transition of nano-drugs, lack of established international standards and protocols, redundant nanoparticle applications, and associated issues regarding the intellectual property rights, etc. Diligent focused efforts from all the stakeholders globally is paying-off as significant improvement have been observed in the “bench to beside” transition of the nano-formulations and newer candidates are reaching the market at regular basis currently which ensures a bright future prospect of nanotechnology in cancer arena.
References
Al-Jamal KT, Al-Jamal WT, Wang JT, Rubio N, Buddle J, Gathercole D et al (2013) Cationic poly-L-lysine dendrimer complexes doxorubicin and delays tumor growth in vitro and in vivo. ACS Nano 7:1905–1917. https://doi.org/10.1021/nn305860k
Anselmo AC, Mitragotri S (2019) Nanoparticles in the clinic: an update. Bioeng Transl Med 4:e10143. https://doi.org/10.1002/btm2.10143
Bae KH, Choi SH, Park SY, Lee Y, Park TG (2006) Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles. Langmuir 22:6380–6384. https://doi.org/10.1021/la0606704
Beltrán-Gracia E, López-Camacho A, Higuera-Ciapara I, Velázquez-Fernández JB, Vallejo-Cardona AA (2019) Nanomedicine review: clinical developments in liposomal applications. Cancer Nano 10:11. https://doi.org/10.1186/s12645-019-0055-y
Bhardwaj V, Kaushik A, Khatib ZM, Nair M, McGoron AJ (2019) Recalcitrant issues and new frontiers in nano-pharmacology. Front Pharmacol 10:1369. https://doi.org/10.3389/fphar.2019.01369
Bobo D, Robinson KJ, Islam J, Thurecht KJ, Corrie SR (2016) Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharm Res 33:2373–2387. https://doi.org/10.1007/s11095-016-1958-5
Cai H, Shukla S, Steinmetz NF (2020) The antitumor efficacy of CpG oligonucleotides is improved by encapsulation in plant virus-like particles. Adv Funct Mater 1908743. https://doi.org/10.1002/adfm.201908743
Chen Q, Tong S, Dewhirst MW, Yuan F (2004) Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome. Mol Cancer Ther 3:1311–1317
Chen Q, Wang C, Zhang X, Chen G, Hu Q, Li H et al (2019) In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment. Nat Nanotechnol 14:89–97. https://doi.org/10.1038/s41565-018-0319-4
Chung YH, Cai H, Steinmetz NF (2020) Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications. Adv Drug Deliv Rev. https://doi.org/10.1016/j.addr.2020.06.024
De Cock I, Lajoinie G, Versluis M, De Smedt SC, Lentacker I (2016) Sonoprinting and the importance of microbubble loading for the ultrasound mediated cellular delivery of nanoparticles. Biomaterials 83:294–307. https://doi.org/10.1016/j.biomaterials.2016.01.022
Deelman LE, Declèves AE, Rychak JJ, Sharma K (2010) Targeted renal therapies through microbubbles and ultrasound. Adv Drug Deliv Rev 62:1369–1377. https://doi.org/10.1016/j.addr.2010.10.002
Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M et al (1998) Photodynamic therapy. J Natl Cancer Inst 90:889–905. https://doi.org/10.1093/jnci/90.12.889
Ganta S, Iyer A, Amiji M (2010) Multifunctional stimuli–responsive nanoparticles for targeted delivery of small and macromolecular therapeutics. Targeted Delivery Small Macromolecular Drugs 555–585. https://doi.org/10.1201/9781420087734-c20
Gao S, Zhang L, Wang G, Yang K, Chen M, Tian et al (2016) Hybrid graphene/Au activatable theranostic agent for multimodalities imaging guided enhanced photothermal therapy. Biomaterials 79:36–45. https://doi.org/10.1016/j.biomaterials.2015.11.041
Garnett MC (2001) Targeted drug conjugates: principles and progress. Adv Drug Deliv Rev 53:171–216. https://doi.org/10.1016/s0169-409x(01)00227-7
Gmeiner WH, Ghosh S (2015) Nanotechnology for cancer treatment. Nanotechnol Rev 3:111–122. https://doi.org/10.1515/ntrev-2013-0013
Gupta AK, Naregalkar RR, Vaidya VD, Gupta M (2007) Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications. Nanomedicine 2:23–39. https://doi.org/10.2217/17435889.2.1.23
Hagan CT 4th, Medik YB, Wang AZ (2018) Nanotechnology approaches to improving cancer immunotherapy. Adv Cancer Res 139:35–56. https://doi.org/10.1016/bs.acr.2018.05.003
Han HD, Shin BC, Choi HS (2006) Doxorubicin-encapsulated thermosensitive liposomes modified with poly(N-isopropylacrylamide-co-acrylamide): drug release behavior and stability in the presence of serum. Eur J Pharm Biopharm 62:110–116. https://doi.org/10.1016/j.ejpb.2005.07.006
Hassan HAFM, Smyth L, Wang JTW, Costa PM, Ratnasothy K, Diebold SS et al (2016) Dual stimulation of antigen presenting cells using carbon nanotube-based vaccine delivery system for cancer immunotherapy. Biomaterials 104:310–322. https://doi.org/10.1016/j.biomaterials.2016.07.005
Jhaveri A, Deshpande P, Torchilin V (2014) Stimuli-sensitive nanopreparations for combination cancer therapy. J Control Release 190:352–370. https://doi.org/10.1016/j.jconrel.2014.05.002
Ji H, Sun H, Qu X (2016) Antibacterial applications of graphene-based nanomaterials: recent achievements and challenges. Adv Drug Deliv Rev 105:176–189. https://doi.org/10.1016/j.addr.2016.04.009
Jiang D, Gao X, Kang T, Feng X, Yao J, Yang M et al (2016) Actively targeting D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactic acid) nanoparticles as vesicles for chemo-photodynamic combination therapy of doxorubicin-resistant breast cancer. Nanoscale 8:3100–3118. https://doi.org/10.1039/c5nr07724a
Johnson RP, Jeong YI, John JV, Chung CW, Kang DH, Selvaraj M et al (2013) Dual stimuli-responsive poly(N-isopropylacrylamide)-b-poly(L-histidine) chimeric materials for the controlled delivery of doxorubicin into liver carcinoma. Biomacromolecules 14:1434–1443. https://doi.org/10.1021/bm400089m
Kaminskas LM, Kelly BD, McLeod VM, Boyd BJ, Krippner GY, Williams ED et al (2009) Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-l-lysine dendrimers. Mol Pharm 6:1190–1204. https://doi.org/10.1021/mp900049a
Kim KY (2007) Nanotechnology platforms and physiological challenges for cancer therapeutics. Nanomedicine 3:103–110. https://doi.org/10.1016/j.nano.2006.12.002
Kim SY, Ha JC, Lee YM (2000) Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)/poly(epsilon-caprolactone) (PCL) amphiphilic block copolymeric nanospheres. II. Thermo-responsive drug release behaviors. J Control Release 65:345–358. https://doi.org/10.1016/s0168-3659(99)00207-2
Kim J, Santos OA, Park JH (2014) Selective photosensitizer delivery into plasma membrane for effective photodynamic therapy. J Control Release 191:98–104. https://doi.org/10.1016/j.jconrel.2014.05.049
Kim H, Chung K, Lee S, Kim DH, Lee H (2016) Near-infrared light-responsive nanomaterials for cancer theranostics. WIREs Nanomed Nanobiotechnol 8:23–45. https://doi.org/10.1002/wnan.1347
Kou L, Sun J, Zhai Y, He Z (2013) The endocytosis and intracellular fate of nanomedicines: implication for rational design. Asian J Pharmaceut Sci 8:1–10. https://doi.org/10.1016/j.ajps.2013.07.001
Kranz LM, Diken M, Haas H, Kreiter S, Loquai C, Reuter KC et al (2016) Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy. Nature 534:396–401. https://doi.org/10.1038/nature18300
Krauss AC, Gao X, Li L, Manning ML, Patel P, Fu W et al (2019) FDA approval summary: (Daunorubicin and Cytarabine) liposome for injection for the treatment of adults with high-risk acute myeloid leukemia. Clin Cancer Res 25:2685–2690. https://doi.org/10.1158/1078-0432.CCR-18-2990
Kuai R, Ochyl LJ, Bahjat KS, Schwendeman A, Moon JJ (2017) Designer vaccine nanodiscs for personalized cancer immunotherapy. Nat Mater 16:489–496. https://doi.org/10.1038/nmat4822
Kumari P, Ghosh B, Biswas S (2016) Nanocarriers for cancer-targeted drug delivery. J Drug Target 24:179–191. https://doi.org/10.3109/1061186X.2015.1051049
Lee J, Min HS, You DG, Kim K, Kwon IC, Rhim T et al (2016) Theranostic gas-generating nanoparticles for targeted ultrasound imaging and treatment of neuroblastoma. J Control Release 223:197–206. https://doi.org/10.1016/j.jconrel.2015.12.051
Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN (2010) Tumor cell killing efficiency of doxorubicin loaded microbubbles after ultrasound exposure. J Control Release 148:e113–e114. https://doi.org/10.1016/j.jconrel.2010.07.085
Li Z, Tan S, Li S, Shen Q, Wang K (2017) Cancer drug delivery in the nano era: an overview and perspectives (review). Oncol Rep 38:611–624. https://doi.org/10.3892/or.2017.5718
Li Y, Ayala-Orozco C, Rauta PR, Krishnan S (2019) The application of nanotechnology in enhancing immunotherapy for cancer treatment: current effects and perspective. Nanoscale 11:17157–17178. https://doi.org/10.1039/c9nr05371a
Liang R, Xie J, Li J, Wang K, Liu L, Gao Y et al (2017) Liposomes-coated gold nanocages with antigens and adjuvants targeted delivery to dendritic cells for enhancing antitumor immune response. Biomaterials 149:41–50. https://doi.org/10.1016/j.biomaterials.2017.09.029
Lovell JF, Jin CS, Huynh E, Jin H, Kim C, Rubinstein JL et al (2011) Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents. Nat Mater 10:324–332. https://doi.org/10.1038/nmat2986
Luo M, Wang H, Wang Z, Cai H, Lu Z, Li Y et al (2017) A STING-activating nanovaccine for cancer immunotherapy. Nat Nanotechnol 12:648–654. https://doi.org/10.1038/nnano.2017.52
Maiti D, Tong X, Mou X, Yang K (2019) Carbon-based nanomaterials for biomedical applications: a recent study. Front Pharmacol 9:1–16. https://doi.org/10.3389/fphar.2018.01401
Malik N, Evagorou EG, Duncan R (1999) Dendrimer-platinate: a novel approach to cancer chemotherapy. Anti-Cancer Drugs 10:767–776
Martinelli C, Pucci C, Ciofani G (2019) Nanostructured carriers as innovative tools for cancer diagnosis and therapy. APL Bioeng 3:011502. https://doi.org/10.1063/1.5079943
Meyer DE, Shin BC, Kong GA, Dewhirst MW, Chilkoti A (2001) Drug targeting using thermally responsive polymers and local hyperthermia. J Control Release 74:213–224. https://doi.org/10.1016/s0168-3659(01)00319-4
Mi Y, Smith CC, Yang F, Qi Y, Roche KC, Serody JS et al (2018) A dual immunotherapy nanoparticle improves T-cell activation and cancer immunotherapy. Adv Mater e1706098. https://doi.org/10.1002/adma.201706098
Miao L, Li L, Huang Y, Delcassian D, Chahal J, Han J et al (2019) Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nat Biotechnol 37:1174–1185. https://doi.org/10.1038/s41587-019-0247-3
Panahi Y, Farshbaf M, Mohammad Hosseini M, Mirahadi M, Khalilov R, Saghfi S et al (2017) Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications. Artif Cells Nanomed Biotechnol 45:788–799. https://doi.org/10.1080/21691401.2017.1282496
Park J-H, von Maltzahn G, Xu MJ, Fogal V, Kotamraju VR, Ruoslahti E et al (2010) Cooperative nanomaterial system to sensitize, target, and treat tumors. Proc Natl Acad Sci USA 107:981–986. https://doi.org/10.1073/pnas.0909565107
Park W, Heo Y, Han DK (2018) New opportunities for nanoparticles in cancer immunotherapy. Biomater Res 22:24. https://doi.org/10.1186/s40824-018-0133-y
Parvanian S, Mostafavi SM, Aghashiri M (2017) Multifunctional nanoparticle developments in cancer diagnosis and treatment. Sens Bio-Sens Res 13:81–87. https://doi.org/10.1016/j.sbsr.2016.08.002
Patil Y, Amitay Y, Ohana P, Shmeeda H, Gabizon A (2016) Targeting of pegylated liposomal mitomycin-C prodrug to the folate receptor of cancer cells: intracellular activation and enhanced cytotoxicity. J Control Release 225:87–95. https://doi.org/10.1016/j.jconrel.2016.01.039
Ponce AM, Vujaskovic Z, Yuan F, Needham D, Dewhirst MW (2006) Hyperthermia mediated liposomal drug delivery. Int J Hyperth 22:205–213. https://doi.org/10.1080/02656730600582956
Prasad M, Kumar R, Buragohain L, Kumari A, Ghosh M (2021) Organoid technology: a reliable developmental biology tool for organ-specific nanotoxicity evaluation. Front Cell Dev Biol 9:696668. https://doi.org/10.3389/fcell.2021.696668
Sanchez C, Belleville P, Popall M, Nicole L (2011) Applications of advanced hybrid organic-inorganic nanomaterials: from laboratory to market. Chem Soc Rev 40(2):696–753. https://doi.org/10.1039/c0cs00136h
Schroeder A, Honen R, Turjeman K, Gabizon A, Kost J, Barenholz Y (2009) Ultrasound triggered release of cisplatin from liposomes in murine tumors. J Control Release 137(1):63–68. https://doi.org/10.1016/j.jconrel.2009.03.007
Shapira A, Livney YD, Broxterman HJ, Assaraf YG (2011) Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance. Drug Resist Updat 14:150–163. https://doi.org/10.1016/j.drup.2011.01.003
Steinmetz NF (2010) Viral nanoparticles as platforms for next-generation therapeutics and imaging devices. Nanomedicine 6:634–641. https://doi.org/10.1016/j.nano.2010.04.005
Tian Q, Tang M, Sun Y, Zou R, Chen Z, Zhu M et al (2011) Hydrophilic flower-like CuS superstructures as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells. Adv Mater 23:3542–3547. https://doi.org/10.1002/adma.201101295
Tran S, De Giovanni PJ, Piel B, Rai P (2017) Cancer nanomedicine: a review of recent success in drug delivery. Clin Transl Med 6:44. https://doi.org/10.1186/s40169-017-0175-0
Turk M, Dinçer S, Pişkin E (2007) Smart and cationic poly(NIPA)/PEI block copolymers as non-viral vectors: in vitro and in vivo transfection studies. J Tissue Eng Regen Med 1:377–388. https://doi.org/10.1002/term.47
Van Zuylen L, Verweij J, Sparreboom A (2001) Role of formulation vehicles in taxane pharmacology. Investig New Drugs 19:125–141. https://doi.org/10.1023/a:1010618632738
Vasir JK, Reddy MK, Labhasetwar VD (2005) Nanosystems in drug targeting: opportunities and challenges. Curr Nanosci 1:47–64. https://doi.org/10.2174/1573413052953110
Wang YC, Wang F, Sun TM, Wang J (2011) Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells. Bioconjug Chem 22(10):1939–1945. https://doi.org/10.1021/bc200139n
Wang L, Shi C, Wright FA, Guo D, Wang X, Wang D et al (2017) Multifunctional Telodendrimer nanocarriers restore synergy of Bortezomib and doxorubicin in ovarian cancer treatment. Cancer Res 77:3293–3305. https://doi.org/10.1158/0008-5472.CAN-16-3119
Wang H, Tang Y, Fang Y, Zhang M, Wang H, He Z et al (2019) Reprogramming tumor immune microenvironment (TIME) and metabolism via biomimetic targeting codelivery of Shikonin/JQ1. Nano Lett 19:2935–2944. https://doi.org/10.1021/acs.nanolett.9b00021
World Health Organization (2018). https://www.who.int/news-room/fact-sheets/detail/cancer
World Health Organization (2020). https://www.who.int/mediacentre/news/releases/2003/pr27/en/
Wu S, Powers S, Zhu W, Hannun YA (2016) Substantial contribution of extrinsic risk factors to cancer development. Nature 529(7584):43–47. https://doi.org/10.1038/nature16166
Yadav PK, Gupta SK, Kumar S, Ghosh M, Yadav BS, Kumar D et al (2020) IL-18 immunoadjuvanted xenogeneic canine MMP-7 DNA vaccine overcomes immune tolerance and suppresses the growth of murine mammary tumor. Int Immunopharmacol 82:106370. https://doi.org/10.1016/j.intimp.2020.106370
Yatvin MB, Weinstein JN, Dennis WH, Blumenthal R (1978) Design of liposomes for enhanced local release of drugs by hyperthermia. Science 202:1290–1293. https://doi.org/10.1126/science.364652
Yoshida R, Uchida K, Kaneko Y, Sakai K, Kikuchi A, Sakurai Y et al (1995) Comb-type grafted hydrogels with rapid deswelling response to temperature changes. Nature 374:240–242. https://doi.org/10.1038/374240a0
Yu GT, Rao L, Wu H, Yang LL, Bu LL, Deng WW et al (2018) Myeloid-derived suppressor cell membrane-coated magnetic nanoparticles for cancer theranostics by inducing macrophage polarization and synergizing immunogenic cell death. Adv Funct Mater 28:1801389. https://doi.org/10.1002/adfm.201801389
Zha Z, Yue X, Ren Q, Dai Z (2013) Uniform polypyrrole nanoparticles with high photothermal conversion efficiency for photothermal ablation of cancer cells. Adv Mater 25:777–782. https://doi.org/10.1002/adma.201202211
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Prasad, M., Buragohain, L., Ghosh, M., Kumar, R. (2022). Nanotechnology in Cancer Diagnosis and Therapy. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_120
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