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Formulation and development of embelin liquisolid systems using quality by design approach

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Abstract

The purpose of the present investigation was to improve dissolution properties of poorly water soluble herbal active ingredient, Embelin (EMB) by formulating liquisolid systems. The new mathematical model was employed for the preparation of the liquisolid systems. Drug loaded liquisolid systems were optimized by utilizing design of experiments (DoE) and principal component analysis (PCA) with carrier-coating ratio (X1) and drug concentration in liquid (X2) as factors. Angle of repose and percentage drug release in 30 min were selected as dependent variables. The liquisolid systems were prepared using Solutol® HS-15 in combination of Synperonic® PE/L61 in ratio of 1:1 as non-volatile liquid, Neusilin US2 as carrier and Aerosil 200 as coating material. The relationship between dependent and independent variables were further explicated through regression analysis and response surface plots. Prepared systems were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and powder X-ray diffraction studies. In-vitro dissolution results revealed significant enhancement in drug release properties from the formulations. Physicochemical characterization of liquisolid systems proposed reduction in drug crystallinity which might be ascribed for improvement in dissolution properties. Study demonstrated successful utilization of Solutol® HS-15 in combination of Synperonic® PE/L61 for dissolution enhancement of EMB.

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Acknowledgments

This article does not contain any studies with human and animal subjects performed by any of authors. All authors (K. Parmar, J. Patel, N. Sheth) declare that they have no conflict of interest. The authors are thankful to Mr. Swapnil Goyal (Asst. Prof., B. R. Nahta College of Pharmacy, Mandsaur, India) for providing the gift sample of EMB. Authors are grateful to Signet, BASF, Torrent Pharmaceuticals Ltd and Gangwal Chemicals Pvt Ltd for endowing the gift sample of Solutol® HS-15, Cemophore RH 40, Transcutol P, Synperonic® PE/L61 and Neusilin US2 respectively.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, 360005, Gujarat, India

    Komal Parmar & Navin Sheth

  2. Nootan Pharmacy College, Visnagar, 384315, Gujarat, India

    Jayvadan Patel

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  1. Komal Parmar
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  2. Jayvadan Patel
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  3. Navin Sheth
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Correspondence to Komal Parmar.

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Parmar, K., Patel, J. & Sheth, N. Formulation and development of embelin liquisolid systems using quality by design approach. Journal of Pharmaceutical Investigation 46, 547–556 (2016). https://doi.org/10.1007/s40005-016-0239-y

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  • DOI: https://doi.org/10.1007/s40005-016-0239-y

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