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Anticancer activities of diphenyl difluoroketone, a novel curcumin analog, on KB human oral cancer cells

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Abstract

Effects of diphenyl difluoroketone (EF-24) and curcumin on cell growth and apoptosis induction in KB human oral cancer cells were examined. EF-24 and curcumin inhibited the growth of KB cells in a dose-dependent manner, and the potency of EF-24 was 30 times greater than that of curcumin. Treatment with EF-24 or curcumin resulted in nuclear condensation and fragmentation. EF-24 and curcumin promoted the proteolytic cleavage of procaspases-3, -7, and -9. Activities of caspases-3 and -7 were detected in living KB cells treated with EF-24 or curcumin. These results suggest that EF-24 and curcumin inhibit cell proliferation and induce apoptosis in KB human oral cancer cells, and have potential properties for development of anti oral cancer drug.

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Authors and Affiliations

  1. Oral Biology Research Institute, Chosun University School of Dentistry, Gwangju, 501-759, Republic of Korea

    Hyun-Sang Jeon, Myung-Hun Jo, Heung-Joong Kim, Myoung-Hwa Lee, Sun-Kyoung Yu, Chun Sung Kim, Su-Gwan Kim, Euteum Park & Do Kyung Kim

  2. Department of Biotechnology, Chosun University, Gwangju, 501-759, Republic of Korea

    Hong Sung Chun & Euteum Park

  3. Regional Innovation Center for Dental Science & Engineering, Chosun University, Gwangju, 501-759, Republic of Korea

    Sook-Young Lee, Su-Gwan Kim & Do Kyung Kim

Authors
  1. Hyun-Sang Jeon
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  2. Myung-Hun Jo
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  3. Heung-Joong Kim
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  4. Myoung-Hwa Lee
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  5. Sun-Kyoung Yu
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  6. Chun Sung Kim
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  7. Sook-Young Lee
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  8. Su-Gwan Kim
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  9. Hong Sung Chun
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  10. Euteum Park
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  11. Do Kyung Kim
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Correspondence to Do Kyung Kim.

Additional information

H. S. Jeon and M. H. Jo contributed equally.

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Jeon, HS., Jo, MH., Kim, HJ. et al. Anticancer activities of diphenyl difluoroketone, a novel curcumin analog, on KB human oral cancer cells. J Korean Soc Appl Biol Chem 55, 451–456 (2012). https://doi.org/10.1007/s13765-012-1168-8

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  • DOI: https://doi.org/10.1007/s13765-012-1168-8

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