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Interleukin-18 promoter polymorphisms and idiopathic Parkinson disease: an Egyptian study

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Abstract

Etiology of sporadic Parkinson’s disease (PD) is largely unknown. The contribution of genetic factors to the pathogenesis of PD is supported by the demonstration of high concordance in twins, increased risk among relatives of PD patients and existence of familial cases. This study aimed to examine the relation between interleukin 18 (IL-18) gene promoter polymorphisms and idiopathic PD, and its impact on clinical presentation and disease severity. 30 idiopathic PD patients and 15 age- and sex-matched healthy subjects were included. Disease severity was assessed using Unified Parkinson’s Disease Rating Scale (UPDRS). Genetic testing for IL-18 gene promoter −607C/A single nucleotide polymorphisms (SNP) was done using real-time polymerase chain reaction (PCR) technique. A raised risk of PD development was found in patients with A/C and C/C genotypes of the site −607C/A (odds ratios = 1.83 and 1.98, respectively). The distribution of the genotypes showed no significant relation to gender or predominant clinical presentation. The age at onset of disease was significantly lower in C/C and A/A genotypes compared to A/C genotype (p = 0.001 and 0.04, respectively). Patients with A/A genotype showed significantly higher mentation score of UPDRS compared to patients with A/C and C/C genotypes (p = 0.003 and p = 0.002, respectively). Polymorphisms of IL-18 gene promoter increase the risk of developing idiopathic PD. The polymorphisms may affect phenotypic expression rather than being a direct cause of idiopathic PD.

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Acknowledgements

The authors acknowledge subjects for their participation and cooperation.

Funding

Personal funding by the authors themselves.

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Authors and Affiliations

  1. Department of Neurology, Cairo University, Giza, Egypt

    Ebtesam Fahmy, Amany Rabah & Hanan Helmy

  2. Department of Clinical Pathology, Cairo University, Giza, Egypt

    Sahar Sharaf

  3. Department of Neurology, Sahel Teaching Hospital, Cairo, Egypt

    Ahmed Kamal

Authors
  1. Ebtesam Fahmy
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  2. Amany Rabah
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  3. Sahar Sharaf
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  4. Hanan Helmy
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  5. Ahmed Kamal
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Contributions

All authors were involved in protocol development and data analysis. SS carried out the molecular genetic studies. EF wrote the first and final draft of the manuscript. AK was involved in patient recruitment. EF and HH reviewed and edited the manuscript and approved the final version of the manuscript.

Corresponding author

Correspondence to Hanan Helmy.

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Conflict of interest

No potential conflict of interest relevant to this article is reported. No official funding.

Ethical approval

The study was approved by the Ethical committee of the institution.

Infomed consent

Patients were informed, and they consented to conduct the study.

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Fahmy, E., Rabah, A., Sharaf, S. et al. Interleukin-18 promoter polymorphisms and idiopathic Parkinson disease: an Egyptian study. Acta Neurol Belg 119, 219–224 (2019). https://doi.org/10.1007/s13760-018-0927-7

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  • DOI: https://doi.org/10.1007/s13760-018-0927-7

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