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Microstructural changes in patients with Parkinson disease and REM sleep behavior disorder: depressive symptoms versus non-depressed

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Abstract

Search for Parkinson’s disease (PD) progression biomarkers has led to the identification of both motor and non-motor symptoms relevant of prodromal PD that could be eye-opening to the spreading underlying Lewy body pathogenesis. One most robust predictor of PD is the REM sleep behavior disorder (RBD), and one most common early non-motor symptom of PD is depression. With RBD, frequently coexisting with clinical depression and both predicting dopamine transmission dysfunction, we aimed to survey structural associates of depressive symptoms in early PD patients with comorbid RBD. Through diffusion MRI connectometry, we tracked fiber differences comparing DWI images obtained from 14 patients with depressive symptoms and 18 without depression from a group with comorbid RBD and PD. DWI images and patients were recruited from the Parkinson’s Progression Markers Initiative database. PD-RBD patients with depressive symptoms showed pathways with significantly reduced connectivity in the right cingulum, left and right fornix, left inferior longitudinal fasciculus, right corticospinal tract, left middle cerebellar peduncle and genu of corpus callosum (FDR = 0.0228). Diffusivity alteration of the mentioned fibers in depressed, early PD patients with RBD might reflect underlying PD pathology and serve as common structural DWI signatures for early PD diagnosis.

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Acknowledgements

PPMI is funded by Grants from the Michael J Fox Foundation for Parkinson’s Research, the W Garfield Weston Foundation, and the Alzheimer’s Association, the Canadian Institutes for Health Research, and the Natural Sciences and Engineering Research Council of Canada. We thank Christian Beckmann and Simon Eickhoff for their advice on data analysis. Data used in this article were obtained from the Parkinson’s Progression Markers Initiative (PPMI) database (http://www.ppmi-info.org/data). For up-to-date information on the study, visit http://www.ppmi-info.org. PPMI is sponsored and partially funded by the Michael J Fox Foundation for Parkinson’s Research and funding partners, including AbbVie, Avid Radiopharmaceuticals, Biogen, Bristol-Myers Squibb, Covance, GE Healthcare, Genentech, GlaxoSmithKline (GSK), Eli Lilly and Company, Lundbeck, Merck, Meso Scale Discovery (MSD), Pfizer, Piramal Imaging, Roche, Servier, and UCB (http://www.ppmi-info.org/fundingpartners).

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Authors and Affiliations

  1. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Farzaneh Ghazi Sherbaf & Farzaneh Rahmani

  2. Basir Eye Health Research Center, Tehran, Iran

    Mohammad Hadi Aarabi

  3. Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany

    Sommayeh Mohammadi Jooyandeh

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  1. Farzaneh Ghazi Sherbaf
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  2. Farzaneh Rahmani
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  3. Sommayeh Mohammadi Jooyandeh
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  4. Mohammad Hadi Aarabi
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Contributions

FGS, FR, and MHA contributed to the conception and design of the study; MHA contributed to data collection and analysis; and FGS, FR, and SMJ contributed to writing the manuscript.

Corresponding author

Correspondence to Mohammad Hadi Aarabi.

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The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

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All procedures performed here, including human participants, were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent had been obtained from all individual participants included in the study, by the PPMI.

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Ghazi Sherbaf, F., Rahmani, F., Jooyandeh, S.M. et al. Microstructural changes in patients with Parkinson disease and REM sleep behavior disorder: depressive symptoms versus non-depressed. Acta Neurol Belg 118, 415–421 (2018). https://doi.org/10.1007/s13760-018-0896-x

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  • DOI: https://doi.org/10.1007/s13760-018-0896-x

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