Abstract
The impact of the quality of our diet on our well-being and on the maintenance of our health is now well recognised. In particular, in recent years the importance of micronutrients contained in food has been highlighted. Micronutrients include not only minerals and vitamins (which have long been recognised and studied for their importance), but also a number of other substances contained in small amounts in our food, which are essential for good health. These include glycosides and flavonoids, which may be classified into different chemical classes such as flavanols, anthocyanins, flavones and others. Most of these are typical of the Mediterranean diet. The beneficial properties of the Mediterranean diet (now recognised by UNESCO as intangible heritage that must be preserved) for human health, and in particular for the heart and the cardiovascular system, may be explained by the content in these compounds. Even wine, an integral part of the Mediterranean diet, when consumed in moderate amounts, has favourable antioxidant activity, improving some aspects of blood circulation. In addition to the intrinsic value of the Mediterranean diet, the recent findings on the beneficial properties of chocolate should be remembered. When consumed in the right quantities, it can also contribute to the proper maintenance of the vascular system.
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WHO Regional Office for Europe (2007) Gaining health: The European Strategy for the Prevention and Control of Noncommunicable Diseases. Denmark, ISBN 92-890 2179 9
Morgan Griffin R. Leading causes of disability. WebMD. http://www.webmd.com/healthy-aging/features/top-causesdisability (accessed 30 June 2014)
WHO (2003) The World Health Report. WHO
WHO (2013) The World Health Report. WHO
Trichopoulou A, Vasilopoulou E (2000) Mediterranean diet and longevity. Br J Nutr 84[Suppl 2]:S205–209
John JH, Ziebland S, Yudkin P, Roe LS, Neil H (2002) Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial. Lancet 359:1969–1974
Ball K, McNaughton SA, Mhurchu CN, Andrianopoulos N, Inglis V, McNeilly B, Le H, Leslie D, Pollard C, Crawford D (2011) Supermarket Healthy Eating for Life (SHELf): protocol of a randomised controlled trial promoting healthy food and beverage consumption through price reduction and skill-building strategies. BMC Public Health 11:715
Joint WHO/FAO Expert Consultation on Diet (2003) Nuintrition and the Prevention of Chronic Disease. WHO Technical Report Series N° 916
Pandey KB, Rizvi SI (2009) Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2(5):270–278
WHO. Micronutrients. http://www.who.int/nutrition/topics/micronutrients/en/ (accessed 30 June 2014)
Grossman E (2008) Does increased oxidative stress cause hypertension? Diabetes Care 31[Suppl 2]:S185–189
Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P (2014) Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci USA doi: 10.1073/pnas.1402965111
British Heart Foundation. Five top tips for making your meals more Mediterranean. http://www.bhf.org.uk/heart%20matters%20online/january%20february%202014/nutrition/mediterranean%20diet.aspx (accessed 30 June 2014)
Serra-Majem L, Roman B, Estruch R (2006) Scientific evidence of interventions using the Mediterranean diet: a systematic review. Nutr Rev 64:S27–47
The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (2012) European Guidelines on cardiovascular disease prevention in clinical practice. Eur J Prev Cardiol 19:585–667
FDA (2004) FDA allows qualified health claim to decrease risk of coronary heart disease. http://www.fda.gov/newsevents/newsroom/pressannouncements/2004/ucm108368.htm (accessed 30 June 2014)
Panagiotakos DB, Pitsavos C, Stefanadis C (2006) Dietary patterns: a Mediterranean diet score and its relation to clinical and biological markers of cardiovascular disease risk. Nutr Metab Cardiovasc Dis 16:559–568
Urpi-Sarda M, Casas R, Chiva-Blanch G, Romero-Mamani ES, Valderas-Martínez P, Arranz S, Andres-Lacueva C, Llorach R, Medina-Remón A, Lamuela-Raventos RM, Estruch R (2012) Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomarkers related to atherosclerosis. Pharm Res 65:577–583
Knoops KT, de Groot LC, Kromhout D, Perrin AE, Moreiras-Varela O, Menotti A, van Staveren WA (2004) Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA 292:1433–1439
Kushi LH, Lenart EB, Willett WC (1995) Health implications of Mediterranean diets in light of contemporary knowledge. 2. Meat, wine, fats, and oils. Am J Clin Nutr 61[Suppl]:1416S–1427S
Di Renzo L, Carraro A, Valente R, Iacopino L, Colica C, De Lorenzo A (2014) Intake of red wine in different meals modulates oxidized LDL level, oxidative and inflammatory gene expression in healthy people: a randomized crossover trial. Oxid Med Cell Longev 2014:681318
Fortes C, Mastroeni S, Melchi F, Pilla MA, Antonelli G, Camaioni D, Alotto M, Pasquini P (2008) A protective effect of the Mediterranean diet for cutaneous melanoma. Intern J Epidemiol 37:1018–1029
Cheynier V (2012) Phenolic compounds: from plants to foods. Phytochem Res 11:153–177
Heiss C, Keen CL, Kelm M (2010) Flavanols and cardiovascular disease prevention. Eur Heart J 31:2583–92
Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. Sci World J 2013:162750
McCullough ML, Peterson JJ, Patel R, Jacques PF, Shah R, Dwyer JT (2012) Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr 95:454–464
Arango D, Morohashi K, Yilmaz A, Kuramochi K, Parihar A, Brahimaj B, Grotewold E, Doseff AI (2013) Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets. Proc Natl Acad Sci USA 110:E2153–2162
Carey FA (2001) Organic chemistry. McGraw-Hill, Boston
Castañeda-Ovando A, Pacheco-Hernández M de L, Páez-Hernández ME, Rodríguez JA, Galán-Vidal CA (2009) Chemical studies of anthocyanins: a review. Food Chem 113:859–871
Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB (2013) High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middleaged women. Circulation 127:188–196
Poudyal H, Panchal S, Brown L (2010) Comparison of purple carrot juice and b-carotene in a high-carbohydrate, high-fat diet-fed rat model of the metabolic syndrome. Br J Nutr 104:1322–1332
Carrillo LC, Londoño-Londoño J, Gil A (2014) Comparison of polyphenol, methylxanthines and antioxidant activity in Theobroma cacao beans from different cocoa-growing areas in Colombia. Food Res Int 60:273–280
Paoletti R, Conti A, Visioli F, Poli A (2001) Chocolate and health. Springer, Milan
Osakabe N (2013) Flavan-3-ols improve metabolic syndrome risk factors: evidence and mechanisms. J Clin Biochem Nutr 52:186–192
EFSA Panel NDA (2012) Scientific opinion on the substantiation of a health claim related to cocoa flavanols and maintenance of normal endothelium-dependent vasodilation pursuant to Article 13(5) of Regulation (EC) No 1924/2006. EFSA J 10:2809–2830
Conti A, Pinorini-Godly MT, Colombo ML (2013) Cocoa and chocolate in humans: the rationale for clinical studies on healthy volunteers. In: Watson RR et al (eds) Chocolate in health and nutrition, Nutrition and Health 7, Springer Science and Business Media, New York
Murphy KJ, Chronopoulos AK, Singh I, Francis MA, Moriarty H, Pike MJ, Turner HA, Mann NJ, Sinclair AJ (2003) Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. Am J Clin Nutr 77:1466–1473
Georgiev V, Ananga A, Tsolova V (2014) Recent advances and uses of grape flavonoids as nutraceuticals. Nutrients 6:391–415
Ames BN (2006) Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci USA 103:17589–17594
University of York. Botany and health: very small chemical changes to dietary flavonoids cause very large effects on human immune system. ScienceDaily 30 August. www.sciencedaily.com/releases/2013/08/130830091800.htm
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Colombo, M.L., Falciola, C., Maffè, S. et al. Beneficial properties of plants and their derived extracts on the cardiovascular system. Nutrafoods 13, 93–101 (2014). https://doi.org/10.1007/s13749-014-0046-x
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DOI: https://doi.org/10.1007/s13749-014-0046-x