Abstract
A growing body of evidences suggests that the regular consumption of a diet rich in fruit and vegetables (FAV) reduces the risk of chronic human illnesses and increase lifespan and quality of life. FAV are considered energy poor, are rich sources of minerals, fibers, vitamins and most of all of many phytochemicals belonging to four main classes: polyphenols, terpenoids, sulphur compounds and alkaloids. Polyphenols, and to a certain extent carotenoids and sulphur containing compounds have been shown through epidemiological cohort studies or through mechanistic in vitro or animal studies, to prevent coronary heart diseases, chronic inflammatory diseases, obesity, diabetes, neurodegenerative diseases, cancer, macular degeneration, and many others. Owing to their particular chemical structure, theses phytochemicals display strong antioxidant capacity in vitro. Yet due to their poor bioavailability and their short residence time in the organism, it is more and more admitted that these molecules trigger detoxification mechanisms in the body and induce genes associated with energy metabolism, anti-inflammation and endogenous-antioxidant network at the cellular level.
This chapter describes the different phytochemicals found in FAV with emphasis on polyphenols, the most important class of compounds in relation to health benefits and amounts ingested on a daily basis in our diet. The contribution of these chemicals to the prevention of chronic diseases is covered and new insights on their possible mode of action are discussed. The scope of this chapter is broad and intends to brush an overview of this very complex and dynamic field of research, at the interface between plant and human physiology. The reader is guided and often referred to bibliographic reviews on topics as diverse and eclectic as phytochemicals biosynthesis, bioavailability, inflammatory responses, cancer etiology, appetite control, insulin resistance, and cognition.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adams LS, Phung S, Yee N et al (2010) Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res 70:3594–3605. doi:10.1158/0008-5472.CAN-09-3565
Adams LS, Kanaya N, Phung S et al (2011) Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. J Nutr 141:1805–1812. doi:10.3945/jn.111.140178
Adisakwattana S, Moonsan P, Yibchok-anun S (2008) Insulin-releasing properties of a series of cinnamic acid derivatives in vitro and in vivo. J Agric Food Chem 56:7838–7844. doi:10.1021/jf801208t
Agrawal AA, Kurashige NS (2003) A role for isothiocyanates in plant resistance against the specialist herbivore Pieris rapae. J Chem Ecol 29:1403–1415. doi:10.1023/A:1024265420375
Aires DJ, Rockwell G, Wang T et al (2012) Potentiation of dietary restriction-induced lifespan extension by polyphenols. Biochim Biophys Acta 1822:522–526. doi:10.1016/j.bbadis.2012.01.005
Aiyer HS, Warri AM, Woode DR (2012) Influence of berry polyphenols on receptor signaling and cell-death pathways: implications for breast cancer prevention. J Agric Food Chem 60(23): 5693–5708
Alberdi G, Rodríguez VM, Miranda J et al (2011) Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutr Metabol 8:29. doi:10.1186/1743-7075-8-29
Ali M, Thomson M, Afzal M (2000) Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance. PLEAFA 62:55–73
Almeida Mélo E, Galvao de Lima VLA, Maciel MIS (2006) Polyphenol, ascorbic acid and total carotenoid contents in common fruits and vegetables. Braz J Food Technol 9:89–94
Andres-Lacueva C, Shukitt-Hale B (2005) Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci 8:111–120. doi:10.1080/10284150500078117
Andriambeloson E, Magnier C, Haan-Archipoff G et al (1998) Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr 128:2324–2333
Anon (2003) USDA database for the proanthocyanidin content of selected foods, 2nd ed. USDA-ARS, Beltsville
Anon (2004) Fruit and vegetables for health. Report of a joint FAO/WHO workshop 46
Anon (2006) Fruits, vegetables and health: a scientific overview, Canadian Produce Marketing Association. IFAVA, Ottawa
Anon (2007) Preventing chronic diseases: a vital investment. WHO, Geneva
Anon (2011) USDA’s My Plate. In: fnic.nal.usda.gov. http://fnic.nal.usda.gov/dietary-guidance/myplatefood-pyramid-resources/usda-myplate-food-pyramid-resources. Accessed 27 Mar 2011
Arai Y, Watanabe S, Kimira M et al (2000) Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 130:2243–2250
Baile CA, Yang J-Y, Rayalam S et al (2011) Effect of resveratrol on fat mobilization. Ann New York Acad Sci 1215:40–47. doi:10.1111/j.1749-6632.2010.05845.x
Barone E, Calabrese V, Mancuso C (2009) Ferulic acid and its therapeutic potential as a hormetin for age-related diseases. Biogerontology 10:97–108. doi:10.1007/s10522-008-9160-8
Bassaganya-Riera J, Skoneczka J, Kingston DGJ et al (2010) Mechanisms of action and medicinal applications of abscisic acid. Curr Med Chem 17:467–478
Basu A, Lyons TJ (2012) Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives. J Agric Food Chem 60:5687–5692. doi:10.1021/jf203488k
Basu A, Du M, Leyva MJ et al (2010) Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutri 140:1582–1587. doi:10.3945/jn.110.124701
Bazzano LA (2005) Dietary intake of fruit and vegetables and risk of diabetis mellitus and cardiovascular diseases. Joint FAO/WHO Workshop fruit and vegetables for health 1–66
Bazzano LA (2006) The high cost of not consuming fruits and vegetables. J Amer Diet Asso 106:1364–1368
Bendich A (1993) Biological functions of carotenoids. In: Canfield LM, Krinsky NI, Olson JA (eds) Carotenoids in human health, 1st ed. New York Academy of Science, New York, pp 61–67
Bland JS (2011) Metabolic syndrome: the complex relationship of diet to conditions of disturbed metabolism. Func Foods Health Dis 1:1–12
Bodrato N, Franco L, Fresia C et al (2009) Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose. J Biol Chem 284:14777–14787. doi:10.1074/jbc.M802604200
Bomser J, Madhavi DL, Singletary K, Smith MLA (1996) In vitro anticancer activity of fruit extract from vaccinium species. Planta Med 62:212–216
Bouvier F, Rahier A, Camara B (2005) Biogenesis, molecular regulation and function of plant isoprenoids. Progr Lipid Res 44:357–429
Brader G, Tas E, Palva ET (2001) Jasmonate-dependent induction of indole glucosinolates in Arabidopsis by culture filtrates of the nonspecific pathogen Erwinia carotovora. Plant Physiol 126:849–860. doi:10.1104/pp.126.2.849
Brasnyó P, Molnár GA, Mohás M et al (2011) Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Brit J Nutr 106:383–389
Brat P, George S, Bellamy A et al (2006) Daily polyphenol intake in France from fruit and vegetables. J Nutr 136:2368–2373
Brewster JL (1994) Onions and other vegetable alliums, 1st ed. CAB International, Wallingford
Bruzzone S, Moreschi I, Usai C et al (2007) Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger. PNAS 104:5759–5764. doi:10.1073/pnas.0609379104
Bruzzone S, Bodrato N, Usai C et al (2008) Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP Ribose as second messenger. J Biol Chem 283:32188–32197. doi:10.1074/jbc.M802603200
Burton-Freeman B (2010) Postprandial metabolic events and fruit-derived phenolics: a review of the science. Brit J Nutr 104:S1–S14. doi:10.1017/S0007114510003909
Carlton Tohill B (2005) Dietary intake of fruit and vegetables and management of body weight. In: WHO, Kobe, pp 1–52
Casadesus G, Shukitt-Hale B, Stellwagen HM et al (2004) Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci 7:309–316. doi:10.1080/10284150400020482
Challier B, Perarnau JM, Viel JF (1998) Garlic, onion and cereal fibre as protective factors for breast cancer: a French case-control study. Eur J Epidemiol 14:737–747
Chen CM (2008) Overview of obesity in Mainland China. Obes Rev 9 Suppl 1:14–21. doi:10.1111/j.1467-789X.2007.00433.x
Cherniack EP (2011) Polyphenols: planting the seeds of treatment for the metabolic syndrome. Nutrition 27:617–623. doi:10.1016/j.nut.2010.10.013
Cherniack EP (2012) A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorders. Br J Nutr 108:794–800. doi:10.1017/S0007114512000669
Choi SS, Lee DH, Lee SH (2012) Blueberry protects LPS-stimulated BV-2 microglia through inhibiting activities of p38 MAPK and ERK1/2. Food Sci Biotechnol 21:1195–1201. doi:10.1007/s10068-012-0156-4
Clifford MN, Scalbert A (2000) Ellagitannins—nature, occurrence and dietary burden. J Sci Food Agri 80:1118–1125. doi:10.1002/(SICI)1097-0010(20000515)80:7 <1118::AID-JSFA570 > 3.0.CO;2–9
Comalada MN, Camuesco DE, Sierra S et al (2005) In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kB pathway. Eur J Immunol 35:584–592. doi:10.1002/eji.200425778
Cooke D, Steward WP, Gescher AJ, Marczylo T (2005) Anthocyans from fruits and vegetables—does bright colour signal cancer chemopreventive activity? Eur J Cancer 41:1931–1940
Corzo-Martínez M, Corzo N, Villamiel M (2007) Biological properties of onions and garlic. Trends Food Sci Technol 18:609–625
Crozier A, Yokota T, Jaganath IB et al (2006) Secondary metabolites in fruits, vegetables, beverages and other plant-based dietary components. In: Crozier A, Clifford MN, Ashihara H (eds) Plant secondary metabolites: occurence, structure and role in the human diet. Blackwell, Oxford, pp 208–302
Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26:1001–1043
Dangles O, Dufour C (2006) Flavonoids-protein interactions. In: Andersen OM, Markham KR (eds) Flavans and proanthocyanidins. Taylor & Francis, Boca Raton, pp 443–469
Dauchet L, Amouyel P, Dallongeville J (2009) Fruits, vegetables and coronary heart disease. Nat Rev Cardiol 6:599–608. doi:10.1038/nrcardio.2009.131
de Lorgeril M, Renaud, Mamelle N et al (1994) Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 343:1454–1459
DeFuria J, Bennett G, Strissel KJ et al (2009) Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J Nutr 139:1510–1516
Del Rio D, Borges G, Crozier A (2010) Berry flavonoids and phenolics: bioavailability and evidence of protective effects. Brit J Nutr 104:S67–S90. doi:10.1017/S0007114510003958
Deprez S, Mila I, Huneau J-F et al (2001) Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells. Antiox Redox Signal 3:957–967. doi:10.1089/152308601317203503
Dias AS, Porawski M, Alonso M et al (2005) Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats. J Nutr 135:2299–2304
Dixon RA, Paiva NL (1995) Stress-induced phenylpropanoid metabolism. Plant Cell 7:1085–1097
Doucet E, Tremblay A (1997) Food intake, energy balance and body weight control. Eur J Clin Nutr 51:846–855
Doughty KJ, Kiddle GA, Pye BJ et al (1995) Selective induction of glucosinolates in oilseed rape leaves by methyl jasmonate. Phytochemistry 38:347350
Duthie SJ (2007) Berry phytochemicals, genomic stability and cancer: evidence for chemoprotection at several stages in the carcinogenic process. Mol Nutr Food Res 51:665–674
Edwards RL, Lyon T, Litwin SE et al (2007) Quercetin reduces blood pressure in hypertensive subjects. J Nutr 137:2405–2411
Fahey JW, Zhang Y, Talalay P (1997) Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. PNAS 94:10367–10372
Faria A, Pestana D, Teixeira D et al (2010) Blueberry anthocyanins and pyruvic acid adducts: anticancer properties in breast cancer cell lines. Phytother Res 24:1862–1869. doi:10.1002/ptr.3213
Flegal KM, Carroll MD, Kit BK (2012) Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 307:491–498. doi:10.1001/jama.2012.40
Fleischauer AT, Arab L (2001) Garlic and cancer: a critical review of the epidemiologic literature. J Nutr 131:1032S–1040S
Ford ES, Will JC, Bowman BA, Venkat Narayan KM (1999) Diabetes mellitus and serum carotenoids: findings from the Third National health and Nutrition Examination Survey. Amer J Epidemiol 149:168–176
Frankel EN, German JB (2006) Antioxidants in foods and health: problems and fallacies in the field. J Sci Food Agri 86:1999–2001. doi:10.1002/jsfa.2616
Fraser PD, Bramley PM (2004) The biosynthesis and nutritional uses of carotenoids. Prog lipid Res 43:228–265
Frisardi V, Solfrizzi V, Seripa D et al (2010) Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer’s disease. Ageing Res Rev 9:399–417. doi:10.1016/j.arr.2010.04.007
Fuhrman B, Aviram M (2001) Flavonoids protect LDL from oxidation and attenuate atherosclerosis. Curr Op Lipid 12:41–48
Galeone C, Pelucchi C, Levi F et al (2006) Onion and garlic use and human cancer. Am J Clin Nutr 84:1027–1032
Galli RL, Bielinski DF, Szprengiel A et al (2006) Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection. NBA 27:344–350. doi:10.1016/j.neurobiolaging.2005.01.017
Gallicchio L, Boyd K, Matanoski G et al (2008) Carotenoids and the risk of developing lung cancer: a systematic review. Amer J Clin Nutr 88:372–383
Ghosh D, Scheepens A (2009) Vascular action of polyphenols. Mol Nutri Food Res 53:322–331. doi:10.1002/mnfr.200800182
Giacalone M, Di Sacco F, Traupe I et al (2011) Antioxidant and neuroprotective properties of blueberry polyphenols: a critical review. Nutr Neurosci 14:119–125. doi:10.1179/1476830511Y.0000000007
Godycki-Cwirko M, Krol M, Krol B et al (2010) Uric acid but not apple polyphenols Is responsible for the rise of plasma antioxidant activity after apple juice consumption in healthy subjects. J Amer Coll Nutr 29:397–406
Gonzalez CA, Riboli E (2006) Diet and cancer prevention: where we are, where we are going. Nutr Cancer 56:225–231
González R, Ballester I, López-Posadas R et al (2011) Effects of flavonoids and other polyphenols on inflammation. Crit Rev Food Sci Nutr 51:331–362. doi:10.1080/10408390903584094
Goodman GE, Thornquist MD, Balmes J et al (2004) The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping β-carotene and retinol supplements. J Nat Cancer Inst 96:1743–1751
Gordillo G, Fang H, Khanna S et al (2009) Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm. Antiox Redox Signal 11:47–58. doi:10.1089/ars.2008.2150
Grace MH, Ribnicky DM, Kuhn P et al (2009) Hypoglycemic activity of a novel anthocyaninrich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine 16:406–415. doi:10.1016/j.phymed.2009.02.018
Gramann J, Gerald L (2005) Terpenoids as plant antioxidants. In: Vitamins & Hormones. Academic Press, pp 505–535
Grant WB (2004) A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortality. Eur Urol 45:271–279
Griffiths G, Trueman L, Crowther TE et al (2002) Onions—a global benefit to health. Phytother Res 16:603–615
Gu Y, Nieves JW, Stern Y et al (2010) Food combination and Alzheimer disease risk: a protective diet. Arch Neurol 67:699–706. doi:10.1001/archneurol.2010.84
Güçlü-Üstünda Ö, Mazza G (2007) Saponins: properties, applications and processing. Crit Rev Food Sci Nutr 47:231–258
Guri AJ, Hontecillas R, Bassaganya-Riera J (2007) Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration. Clin Nutr 26:107–116
Guri AJ, Hontecillas R, Bassaganya-Riera J (2010a) Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR [gamma] axis. Clin Nutr 29:646–653
Guri AJ, Misyak SA, Hontecillas R et al (2010b) Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4 + T cell recruitment into the aortic wall. J Nutr Biochem 21:1178–1185. doi:10.1016/j.jnutbio.2009.10.003
Habauzit V, Morand C (2012) Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians. Thera Adv Chron Dis 3(2):87–106
Håkansson A, Bränning C, Molin G et al (2012) Blueberry husks and probiotics attenuate colorectal inflammation and oncogenesis, and liver injuries in rats exposed to cycling DSS-treatment. PLoS ONE 7:e33510. doi:10.1371/journal.pone.0033510
Halliwell B, Rafter J, Jenner A (2005) Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Am J Clin Nutr 81:268S–276S
Hamer M, Chida Y (2007) Intake of fruit, vegetables, and antioxidants and risk of type 2 diabetes: systematic review and meta-analysis. J Hypertension 25:2361–2369
Hanhineva K, Törrönen R, Bondia-Pons I et al (2010) Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci 11:1365–1402. doi:10.3390/ijms11041365
Harborne JB (1977) Phytochemistry of fruits and vegetables: an ecological overview. In: Tomas-Barberan FA, Robins RJ (eds) Proceedings of the phytochemical society of Europe—phytochemistry of fruit and vegetables. Clarendon Press, Oxford, pp 353–367
Haslam E, Lilley TH (1988) Natural astringency of foodstuffs—a molecular interpretation. CRC Rev Food Sci Nutr 27:1–40
He FJ, Nowson CA, MacGregor GA (2006) Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet 367:320–326
Hercberg S, Galan P, Preziosi P et al (2004) The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 164:2335–2342. doi:10.1001/archinte.164.21.2335
Hermsdorff HHM, Zulet MA, Puchau B, Martinez JA (2010) Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutr Metabol 7:42. doi:10.1186/1743-7075-7-42
Hertog MG, Kromhout D, Aravanis C et al (1995) Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 155:381–386
Hollman PCH, Arts ICW (2000) Flavonols, flavones and flavanols—nature, occurrence and dietary burden. J Sci Food Agri 80:1081–1093. doi:10.1002/(SICI)1097-0010(20000515)80:7 <1081::AID-JSFA566> 3.0.CO;2–G
Hollman PCH, Cassidy A, Comte B et al (2011a) The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established. J Nutr 141:989S–1009S. doi:10.3945/jn.110.131490
Hollman PCH, Cassidy A, Comte B et al (2011b) The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established. The journal of Nutrition 141:989S–1009S. doi:10.3945/jn.110.131490
Hu J, La Vecchia C, Negri E et al (1999) Diet and brain cancer in adults: a case-control study in northeast China. Int J Cancer 81:20–23
Hubbard GP, Wolffram S, Lovegrove JA, Gibbins JM (2006) Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. J Thromb Haem 2:2138–2145
Hughes DA (1999) Effects of carotenoids on human immune fonction. Proc Nutr Soc 58:713–718
Hung H-C, Joshipura KJ, Jiang R et al (2004) Fruit and vegetable intake and risk of major chronic disease. J Nat Cancer Inst 96:1577–1584. doi:10.1093/jnci/djh296
Jeong W-S, Jun M, Kong A-NT (2006) Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Antiox Redox Sign 8:99–106. doi:10.1089/ars.2006.8.99
Jia H-F, Chai Y-M, Li C-L et al (2011) Abscisic acid plays an important role in the regulation of strawberry fruit ripening. Plant Physiol 157:188–199. doi:10.1104/pp.111.177311
Jordt S-E, McKemy DD, Julius D (2003) Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Op Neurobiol 13:487–492
Joseph JA, Shukitt-Hale B, Denisova NA et al (1998) Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci 18:8047–8055
Joseph JA, Fisher DR, Cheng V et al (2008) Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. J Agric Food Chem 56:10544–10551. doi:10.1021/jf802279h
Kalea AZ, Clark K, Schuschke DA, Klimis-Zacas DJ (2009) Vascular reactivity is affected by dietary consumption of wild blueberries in the Sprague-Dawley rat. J Med Food 12:21–28. doi:10.1089/jmf.2008.0078
Kausar H, Jeyabalan J, Aqil F et al (2012) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Let 325:54–62. doi:10.1016/j.canlet.2012.05.029
Keck AS, Finley JW (2004) Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium. Integr Cancer Therap 3:5–12
Kendall CWC, Jenkins DJA (2004) A dietary portfolio: maximal reduction of low-density lipoprotein cholesterol with diet. Curr Atheroscler Rep 6:492–498
Khaw KT, Wareham NJ, Bingham SA et al (2007) Combined impact of health behaviours and mortality in men and women: The EPIC-Norfolk prospective population study. PLOS Med 5:e12
Kiddle GA, Doughty KJ, Wallsgrove RM (1994) Salicylic acid-induced accumulation of glucosinolate biosynthesis from Brassica juncea cell cultures. J Exp Bot 45:1343–1346
Kim KH, Park Y (2011) Food components with anti-obesity effect. Ann Rev Food Sci Technol 2:237–257
Kimura M, Rodriguez-Amaya DB (2003) Carotenoid composition of hydroponic leafy vegetables. J Agric Food Chem 51:2603–2607
Kliebenstein DJ, Kroymann J, Mitchell-Olds T (2005) The glucosinolate-myrosinase system in an ecological and evolutionary context. Curr Op Plant Biol 8:264–271
Kliebenstien DJ (2004) Secondary metabolites and plant/environment interactions: a view through Arabidopsis thaliana tinged glasses. Plant, Cell & Environment 27:675–684
Klipstein-Goldberg K, Launer LJ, Geleinjnse JM et al (2000) Serum carotenoids and atherosclerosis: the Rotterdam study. Atherosclerosis 148:49–56
Knekt P, Jarvinen R, Teppo L et al (1999) Role of various carotenoids in lung cancer prevention. J Nat Cancer Inst 91:182–184
Kogure K, Goto S, Nishimura M et al (2002) Mechanism of potent antiperodixidative effect of capsaicin. Biochim Biophys Acta 1573:84–92
Kraft TFB, Schmidt BM, Yousef GG et al (2006) Chemopreventive potential of wild lowbush blueberry fruits in multiple stages of carcinogenesis. J Food Sci 70:S159–S166. doi:10.1111/j.1365-2621.2005.tb07151.x
Krikorian R, Shidler MD, Nash TA et al (2010) Blueberry supplementation improves memory in older adults. J Agric Food Chem 58:3996–4000. doi:10.1021/jf9029332
Kroon PA, Clifford MN, Crozier A et al (2004) How should we assess the effects of exposure to dietary polyphenols in vitro? Am J Clin Nutr 80:15–21
Kubec R, Svobodova M, Velisek J (2000) Distribution of S-alk(en)ylcysteine sulfoxides in some Allium species. Identification of a new flavor precursor: S-ethylcysteine sulfoxide (Ethiin). J Agric Food Chem 48:428–433. doi:10.1021/jf990938f
Kuhnau J (1976) A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 24:117–191
Labbe D, Provençal M, Lamy S et al (2009) The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration. J Nutr 139:646–652. doi:10.3945/jn.108.102616
Lampe JW (1999) Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am J Clin Nutr 70:475S–490S
Lamport DJ, Dye L, Wightman J, Lawton CL (2012) The effects of flavonoid and other polyphenol consumption on cognitive performance: a systematic research review of human experimental and epidemiological studies Nutri Aging 1:5–25. doi:10.3233/NUA-2012-0002
Lancaster JE, Kelly KE (1983) Quantitative analysis of the S-alk(en)yl-L-cysteine sulphoxides in onion (Allium cepa L.). J Sci Food Agri 34:1229–1235. doi:10.1002/jsfa.2740341111
Lau FC, Shukitt-Hale B, Joseph JA (2005) The beneficial effects of fruit polyphenols on brain aging. NBA 26 Suppl 1:128–132. doi:10.1016/j.neurobiolaging.2005.08.007
Lepage-Degivry MT, Bidard NN, Rouvier E et al (1986) Presence of abscisic acid, a phytohormone, in mammalian brain. PNAS 83:1155–1158
Letenneur L, Proust-Lima C, Le Gouge A et al (2007) Flavonoid intake and cognitive decline over a 10-year period. Amer J Epidem 165:1364–1371. doi:10.1093/aje/kwm036
Limpens J, Schroder FH, de Ridder CMA et al (2006) Combined lycopene and vitamin E treatment suppresses the growth of PC-346C human prostate cancer cells in nude mice. J Nutr 136:1287–1293
Loke WM, Hodgson JM, Proudfoot JM et al (2008a) Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am J Clin Nutr 88:1018–1025
Loke WM, Proudfoot JM, Stewart S et al (2008b) Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity. Biochem Pharmacol 75:1045–1053
Long LH, Clement MV, Halliwell B (2000) Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (−)-epigallocatechin, (−)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem Biophys Acta 273:50–53
Lotito SB, Frei B (2006) Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Rad Biol Med 41:1727–1746
Macheix J-J, Fleuriet A, Billot J. (1990) Fruits phenolics. Boca Raton, Fla. CRC Press, p 378
Manach C, Williamson G, Morand C et al (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81:230S–242
Mantena SK, Baliga MS, Katiyar SK (2006) Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis 27:1682–1691. doi:10.1093/carcin/bgl030
Martineau LC, Couture A, Spoor D et al (2006) Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait. Phytomedicine 13:612–623
Matchett MD, MacKinnon SL, Sweeney MI et al (2006) Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events. J Nutr Biochem 17:117–125. doi:10.1016/j.jnutbio.2005.05.014
Mathews-Roth MM (1993) Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann New York Acad Sci 691:127–138
McDougall GJ, Kulkarni NN, Stewart D (2008) Current developments on the inhibitory effects of berry polyphenols on digestive enzymes. BioFactors 34:73–80
McDougall GJ, Stewart D (2005) The inhibitory effects of berry polyphenols on digestive enzymes. BioFactors 23:189–195
McGhie TK, Ainge GD, Barnett LE et al (2003) Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolized by both humans and rats. J Agric Food Chem 51:4539–4548
McIntyre KL, Harris CS, Saleem A et al (2009) Seasonal phytochemical variation of anti-glycation principles in lowbush blueberry (Vaccinium angustifolium). Planta Med 75:286–292. doi:10.1055/s-0028-1088394
McNaughton SA, Marks GC (2003) Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables. Brit J Nutr 90:687–697
Milbury PE, Vita JA, Blumberg JB (2010) Anthocyanins are bioavailable in humans following an acute dose of cranberry juice. J Nutr 140:1099–1104. doi:10.3945/jn.109.117168
Milner JA (2001) Garlic: the mystical food in health promotion. In: Wildman REC (ed) Handbook of nutraceuticals and functional foods. CRC Press, Boca Raton, pp 193–207
Moghe SS, Juma S, Imrhan V (2012) Effect of blueberry polyphenols on 3T3-F442A preadipocyte differentiation. J Med Food 15:448–452
Molan AL, Lila MA, Mawson J (2008) Satiety in rats following blueberry extract consumption induced by appetite-suppressing mechanisms unrelated to in vitro or in vivo antioxidant capacity. Food Chem 107:1039–1044
Munday R, Munday JS, Munday CM (2003) Comparative effects of mono-, di-, tri-, and tetrasulfides derived from plants of the Allium family: redox cycling in vitro and hemolytic activity and Phase 2 enzyme induction in vivo. Free Rad Biol Med 34:1200–1211
Murphy BT, MacKinnon SL, Yan X et al (2003) Identification of triterpene hydroxycinnamates with in vitro antitumor activity from whole cranberry fruit (Vaccinium macrocarpon). J Agric Food Chem 51:3541–3545. doi:10.1021/jf034114g
Ness AR, Powles JW (1997) Fruit and vegetables, and cardiovascular disease: a review. Internat J Epidemiol 26:1–13
Neto CC (2007) Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol Nutr Food Res 51:652–664. doi:10.1002/mnfr.200600279
Neto CC, Amoroso JW, Liberty AM (2008) Anticancer activities of cranberry phytochemicals: an update. Mol Nutr Food Res 52:S18–S27. doi:10.1002/mnfr.200700433
Omenn GS, Goodman GE, Thornquist MD et al (1996) Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334:1150–1155. doi:10.1056/NEJM199605023341802
Ono M, Masuoka C, Koto M et al (2002) Antioxidant ortho-benzoyloxyphenyl acetic acid ester, vaccihein A, from the fruit of rabbiteye blueberry (Vaccinium ashei). Chem Pharm Bull 50:1416–1417
Ostertag LM, O’Kennedy N, Kroon PA et al (2010) Impact of dietary polyphenols on human platelet function–a critical review of controlled dietary intervention studies. Mol Nutri Food Res 54:60–81. doi:10.1002/mnfr.200900172
Pajuelo D, Díaz S, Quesada H et al (2011) Acute administration of grape seed proanthocyanidin extract modulates energetic metabolism in skeletal muscle and BAT mitochondria. J Agric Food Chem 59(8):4279–4287. doi:10.1021/jf200322x
Palozza P, Krinsky NI (1992) Antioxidant effects of carotenoids in vivo and in vitro: an overview. Meth Enzymol 213:403–420
Papandreou MA, Dimakopoulou A, Linardaki ZI et al (2009) Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity. Behaviour Brain Res 198:352–358. doi:10.1016/j.bbr.2008.11.013
Parr AJ, Bolwell GP (2000) Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenols content or profile. J Sci Food Agric 80:985–1012
Perera RM, Bardeesy N (2011) Cancer: when antioxidants are bad. Nature London 475:43–44. doi:10.1038/475043a
Perez-Vizcaino F, Duarte J, Andriantsitohaina R (2006) Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radic Res 40:1054–1065. doi:10.1080/10715760600823128
Potter JD (2005) Vegetables, fruit, and cancer. Lancet 366:527–530
Prasad K, Laxdal VA, Yu M, Raney BL (1995) Antioxidant activity of allicin, an active principle in garlic. Mol Cell Biochem 148:183–189. doi:10.1007/BF00928155
Price KR, Johnson IT, Fenwick GR (1987) The chemistry and biological significance of saponins in foods and feeding stuffs. CRC Rev Food Sci Nutr 26:27–137
Prior RL, Wu X (2006) Anthocyanins: structural characteristics that result in unique metabolic patterns and biological activities. Free Radic Res 40:1014–1028. doi:10.1080/10715760600758522
Proteggente AR, Pannala AS, Paganga G et al (2002) The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition. Free Radic Res 36:217–233
Ramassamy C (2006) Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur J Pharmacol 545:51–64. doi:10.1016/j.ejphar.2006.06.025
Rao A, Rao L (2007) Carotenoids and human health. Pharmacol Res 55:207–216. doi:10.1016/j.phrs.2007.01.012
Rao AV, Agarwal S (1998) Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr Cancer 31:199–203. doi:10.1080/01635589809514703
Rechner AR, Kroner C (2005) Anthocyanins and colonic metabolites of dietary polyphenols inhibit platelet function. Thromb Res 116:327–334. doi:10.1016/j.thromres.2005.01.002
Reinbach HC, Smeets A, Martinussen T et al (2009) Effects of capsaicin, green tea and CH-19 sweet pepper on appetite and energy intake in humans in negative and positive energy balance. Clin Nutr 28:260–265. doi:10.1016/j.clnu.2009.01.010
Rendeiro C, Vauzour D, Kean RJ et al (2012) Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology 223:319–330. doi:10.1007/s00213-012-2719-8
Riccioni G (2009) Carotenoids and cardiovascular disease. Curr Atheroscler Rep 11:434–439. doi:10.1007/s11883-009-0065-z
Riso P, Visioli F, Grande S et al (2006) Effect of a tomato-based drink on markers of inflammation, immunomodulation, and oxidative stress. J Agric Food Chem 54:2563–2566. doi:10.1021/jf053033c
Rissanen TH, Voutilainen S, Virtanen JK et al (2003) Low intake of fruits, berries and vegetables is associated with excess mortality in men: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study. J Nutr 133:199–204
Ristow M, Zarse K, Oberbach A et al (2009) Antioxidants prevent health-promoting effects of physical exercise in humans. PNAS 106:8665–8670. doi:10.1073/pnas.0903485106
Rodriguez-Amaya DB, Kimura M, Godoy HT, Amaya-Farfan J (2008) Updated Brazilian database on food carotenoids: factors affecting carotenoid composition. J Food Comp Anal 21:445–463
Romero C, Brenes M, García P, Garrido A (2002) Hydroxytyrosol 4-β- d-glucoside, an important phenolic compound in olive fruits and derived products. J Agric Food Chem 50:3835–3839. doi:10.1021/jf011485t
Rosa WA, Heaney RK, Fenwick GR, Portas CAM (1997) Glucosinolates in crop plants. Horticult Rev 19:99–215
Rose P, Whiteman M, Moore PK, Zhu YZ (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. NPR 22:351–368
Rothwell JA, Urpi-Sarda M, Boto-Ordonez M et al (2012) Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals. Database 2012:1–8. doi:10.1093/database/bas031
Sabour-Pickett S, Nolan JM, Loughman J, Beatty S (2012) A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration. Mol Nutr Food Res 56:270–286. doi:10.1002/mnfr.201100219
Saura-Calixto F (2012) Concept and health-related properties of nonextractable polyphenols: the missing dietary polyphenols. J Agric Food Chem 60:11195–11200. doi:10.1021/jf303758j
Scalbert A, Williamson G (2000) Dietary intake and bioavailability of polyphenols. J Nutr 130:2073S–2085S
Scalbert A, Johnson IT, Saltmarsh M (2005) Polyphenols: antioxidants and beyond. Am J Clin Nutr 81:215S–217
Scheepens A, Tan K, Paxton JW (2010) Improving the oral bioavailability of beneficial polyphenols through designed synergies. Genes Nutr 5:75–87. doi:10.1007/s12263-009-0148-z
Schewe T, Steffen Y, Sies H (2008) How do dietary flavanols improve vascular function? A position paper. Arch Biochem Biophys 476:102–106. doi:10.1016/j.abb.2008.03.004
Schmidt BM, Erdman JW Jr, Lila MA (2006) Differential effects of blueberry proanthocyanidins on androgen sensitive and insensitive human prostate cancer cell lines. Cancer Let 231:240–246. doi:10.1016/j.canlet.2005.02.003
Seeram NP (2008) Berry fruits for cancer prevention: current status and future prospects. J Agric Food Chem 56:630–635
Seeram NP, Adams LS, Zhang Y et al (2006) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cellsin vitro. J Agric Food Chem 54:9329–9339. doi:10.1021/jf061750g
Serrano J, Puupponen-Pimiä R, Dauer A et al (2009) Tannins: current knowledge of food sources, intake, bioavailability and biological effects. Mol Nutr Food Res 53:S310–S329. doi:10.1002/mnfr.200900039
Shaw JE, Sicree RA, Zimmet PZ (2010) Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87:4–14
Shukitt-Hale B, Lau FC, Joseph JA (2008) Berry fruit supplementation and the aging brain. J Agric Food Chem 56:636–641. doi:10.1021/jf072505f
Smith MAL, Marley KA, Seigler D et al (2000) Bioactive properties of wild blueberry fruits. J Food Sci 65:352–356. doi:10.1111/j.1365-2621.2000.tb16006.x
Snodderly DM (1995) Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr 62:1448S–1461
Spencer JPE (2008) Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance. Proc Nutr Soc 67:238–252
Srivastava KC (1986) Onion exerts antiaggregatory effects by altering arachidonic acid metabolism in platelets. Prostag Leukotr Med 24:43–50
Stahl W, Sies H (2005) Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta 1740:101–107
Steffen Y, Gruber C, Schewe T, Sies H (2008) Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Arch Biochem Biophys 469:209–219. doi:10.1016/j.abb.2007.10.012
Stintzing FC, Carle R (2007) Betalains—emerging prospects for food scientists. Trends Food Sci Technol 18:514–525. doi:10.1016/j.tifs.2007.04.012
Suh N, Paul S, Hao X et al (2007) Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin Cancer Res 13:350–355. doi:10.1158/1078-0432.CCR-06-1528
Surh Y-J, Sup Lee S (1995) Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential. Life Sci 56:1845–1855
Szkudelska K, Szkudelski T (2010) Resveratrol, obesity and diabetes. Eur J Pharmacol 635:1–8. doi:10.1016/j.ejphar.2010.02.054
Talalay P, Fahey JW (2001) Phytochemicals from cruciferous plants protect agains cancer by modulating carcinogen matabolism. Journal of Nutrition 131:3027–3033
Tomas-Barberan FA, Gil MI (2008) Improving the health-promoting properties of fruit and vegetable product. Woodhead Publishing Limited, CRC Press, Cambridge
Traka M, Mithen R (2009) Glucosinolates, isothiocyanates and human health. Phytochem Rev 8:269–282. doi:10.1007/s11101-008-9103-7
Trichopoulou A, Naska A, Antoniou A et al (2003) Vegetable and fruit: the evidence in their favour and the public health perspective. Int J Vitam Nutr Res 73:63–69
van den Berg H, Faulks R, Granado HF (2000) The potential for the improvement of carotenoid levels in foods and the likely systemic effects. J Sci Food Agri 80:880–912. doi:10.1002/(SICI)1097-0010(20000515)80:7 <880::AID-JSFA646> 3.0.CO;2–1
Van’t Veer P, Jansen MCJF, Klerk M, Kok FJ (2000) Fruits and vegetables in the prevention of cancer and cardiovascular disease. Pub Health Nutr 3:103–107
Verkerk R, Schreiner M, Krumbein A et al (2009) Glucosinolates in Brassica vegetables: the influence of the food supply chain on intake, bioavailability and human health. Mol Nutr Food Res 53:S219–S256. doi:10.1002/mnfr.200800065
Voorrips LE, Goldbohm RA, van Poppel G et al (2000) Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study: the Netherlands Cohort Study on Diet and Cancer. Amer J Epidem 152:1081–1092
Voutilainen S, Nurmi T, Mursu J, Rissanen TH (2006) Carotenoids and cardiovascular health. Amer J Clin Nutr 83:1265–1271
Vuong T, Martineau L, Ramassamy C et al (2007) Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharm 85:956–965
Vuong T, Matar C, Ramassamy C (2010) Biotransformed blueberry juice protects neurons from hydrogen peroxide-induced oxidative stress and mitogen-activated protein kinase pathway alterations. Brit J Nutr 104:656–663
Waffo-Teguo P, Krisa S, Richard T, Mérillon J-M (2008) Grapevine stilbenes and their biological effects. In: Ramawat KG, Mérillon JM (eds) Bioactive molecules and medicinal plants. Springer, pp 25–54
Wedge DE, Meepagala KM, Magee JB et al (2001) Anticarcinogenic activity of strawberry, blueberry, and raspberry extracts to breast and cervical cancer cells. J Med Food 4:49–51. doi:10.1089/10966200152053703
Williams CM, El-Mohsen MA, Vauzour D et al (2008) Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Rad Biol Med 45:295–305. doi:10.1016/j.freeradbiomed.2008.04.008
Williams RJ, Spencer J (2011) Flavonoids, cognition and dementia: actions, mechanisms and potential therapeutic utility for Alzheimer’s disease. Free Rad Biol Med 52:35–45
Williamson G, Clifford MN (2010) Colonic metabolites of berry polyphenols: the missing link to biological activity? Brit J Nutr 104:S48–S66. doi:10.1017/S0007114510003946
Wilms LC, Hollman PCH, Boots AW, Kleinjans JCS (2005) Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes. Mut Res/Gen Toxicol Environ Mutagen 582:155–162. doi:10.1016/j.mrgentox.2005.01.006
Woods SC, D’Alessio DA (2008) Central control of body weight and appetite. J Clin Endocrinol Metab 93:s37–s50. doi:10.1210/jc.2008-1630
World Cancer Research Fund (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. World Cancer Research Fund, Washington DC: AICR
Wu X, Kang J, Xie C et al (2010) Dietary blueberries attenuate atherosclerosis in apolipoprotein E-deficient mice by upregulating antioxidant enzyme expression. J Nutr 140:1628–1632. doi:10.3945/jn.110.123927
Xie C, Kang J, Ferguson ME et al (2011) Blueberries reduce pro-inflammatory cytokine TNF-α and IL-6 production in mouse macrophages by inhibiting NF-κB activation and the MAPK pathway. Mol Nut Food Res 55:1587–1591. doi:10.1002/mnfr.201100344
You WC, Li JY, Zhang L et al (2005) Etiology and prevention of gastric cancer: a population study in high risk area of China. Chin J Digest Dis 6:149–154
Youdim KA, Shukitt-Hale B, MacKinnon SL et al (2000) Polyphenolics enhance red blood cell resistance to oxidative stress: in vitro and in vivo. Biochem Biophys Acta 1523:117–122
Zifkin M, Jin A, Ozga JA et al (2012) Gene expression and metabolite profiling of developing highbush blueberry fruit indicates transcriptional regulation of flavonoid metabolism and activation of abscisic acid metabolism. Plant Physiol 158:200–224. doi:10.1104/pp.111.180950
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Desjardins, Y. (2014). Fruit and Vegetables and Health: An Overview. In: Dixon, G., Aldous, D. (eds) Horticulture: Plants for People and Places, Volume 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8560-0_2
Download citation
DOI: https://doi.org/10.1007/978-94-017-8560-0_2
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-017-8559-4
Online ISBN: 978-94-017-8560-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)