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Vitamin C as a green and robust catalyst for the fast and efficient synthesis of valuable organic compounds via multi-component reactions in water

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Abstract

In the present paper, we report l-ascorbic acid (vitamin C) as an efficient and robust catalyst for the straightforward synthesis of various organic compounds, including carboxamide, benzodiazepine and benzoxazepine derivatives. These compounds with potential drug value which exhibit a broad spectrum biological and pharmacological activities were successfully accessed with vitamin C catalytic system under environmentally friendly conditions in water. The main advantages of this protocol are operational simplicity, mild reaction conditions, high yields in short reaction time and good substrate generality.

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Acknowledgements

We gratefully acknowledge financial support of the Research Council of Shahid Beheshti University and the Iran National Science Foundation (INSF).

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Authors and Affiliations

  1. Faculty of Chemistry, Shahid Beheshti University, G.C., P.O. Box 19396-4716, Tehran, Iran

    Ahmad Shaabani, Vida Khodkari, Mohammad Taghi Nazeri, Shima Ghasemi, Reza Mohammadian & Shabnam Shaabani

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  1. Ahmad Shaabani
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  2. Vida Khodkari
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  3. Mohammad Taghi Nazeri
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  4. Shima Ghasemi
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  5. Reza Mohammadian
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Correspondence to Ahmad Shaabani.

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Shaabani, A., Khodkari, V., Nazeri, M.T. et al. Vitamin C as a green and robust catalyst for the fast and efficient synthesis of valuable organic compounds via multi-component reactions in water. J IRAN CHEM SOC 16, 1793–1800 (2019). https://doi.org/10.1007/s13738-019-01655-w

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