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Synthesis and anti-bacterial evaluation of novel thio- and oxazepino[7,6-b]quinolines

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Abstract

Cyclocondensation of 2-chloroquinoline-3-carbaldehydes and 2-thiophenol/2-aminophenols led to the formation of benzo[2,3][1,4]thio- or oxazepino[7,6-b]quinolines. Ugi reaction of the latter compound with various carboxylic acids and isocyanides gave novel oxazepino[7,6-b]quinoline derivatives. All compounds were evaluated for their anti-bacterial and anti-fungal activities. Among them, compounds 4a, 4b and 4d showed moderate to good activity.

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Acknowledgments

We thank Alzahra University and Iran National Science Foundation (INSF) for the financial support.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Physics & Chemistry, Alzahra University, Vanak, 1993893973, Tehran, Iran

    Hoda Hamidi, Majid M. Heravi, Morteza Shiri & Hossein A. Oskooie

  2. Department of Chemistry, University of Mazandaran, Babolsar, Iran

    Mahmoud Tajbakhsh

  3. School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa

    Suhas A. Shintre & Neil A. Koorbanally

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  1. Hoda Hamidi
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  2. Majid M. Heravi
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  3. Mahmoud Tajbakhsh
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  4. Morteza Shiri
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  5. Hossein A. Oskooie
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Correspondence to Majid M. Heravi or Morteza Shiri.

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Hamidi, H., Heravi, M.M., Tajbakhsh, M. et al. Synthesis and anti-bacterial evaluation of novel thio- and oxazepino[7,6-b]quinolines. J IRAN CHEM SOC 12, 2205–2212 (2015). https://doi.org/10.1007/s13738-015-0698-5

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  • DOI: https://doi.org/10.1007/s13738-015-0698-5

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