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Ammonium acetate mediated synthesis of 5-substituted 1H-tetrazoles

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Abstract

Synthesis of 5-substituted 1H-tetrazoles was achieved by [3+2] cycloaddition of nitriles and sodium azide in the presence of ammonium acetate. The reaction proceeds in situ formation of ammonium azide. Present protocol has advantage of good to excellent yields, short reaction times and simple isolation of products than reported methods.

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Acknowledgments

The authors thank to DST and UGC, New Delhi for financial assistance.

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Authors and Affiliations

  1. Department of Organic Chemistry, North Maharashtra University, Jalgaon, 425 001, Maharashtra, India

    Dipak R. Patil, Mukesh B. Deshmukh & Dipak S. Dalal

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  1. Dipak R. Patil
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  2. Mukesh B. Deshmukh
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  3. Dipak S. Dalal
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Correspondence to Dipak S. Dalal.

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Patil, D.R., Deshmukh, M.B. & Dalal, D.S. Ammonium acetate mediated synthesis of 5-substituted 1H-tetrazoles. J IRAN CHEM SOC 9, 799–803 (2012). https://doi.org/10.1007/s13738-012-0080-9

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  • DOI: https://doi.org/10.1007/s13738-012-0080-9

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