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Genetic Risk Factors for Development of Atopic Dermatitis: a Systematic Review

  • Epidemiology (R Dellavalle, Section Editor)
  • Published:
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Abstract

Purpose of Review

The purpose of this study is to systematically review studies conducted between April 2015 and April 2017 for the genetic risks for the development of atopic dermatitis (AD). We sought to identify (1) specific loci and genes associated with AD, (2) the proportion of studies for each gene, and (3) genetic risks that need further investigation.

Recent Findings

Studies have found that genetic predisposition and environmental triggers are involved in the pathogenesis of AD. Thirty-four loci and 46 genes have been identified as genetic risk factors, of which filaggrin gene null mutations and genes in the type 2 T-helper lymphocyte (Th2) signaling pathway have been the most extensively studied.

Summary

Our systematic review found that in the last 2 years, 46 loci and 53 genes have been studied in the development of AD. Genes involved in epidermal barrier, immune regulation, and intracellular functions were identified. We suggest that future research should investigate the intricate interaction of these genes as well as the complex interplay of genetic and environmental factors in the development of AD.

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Authors and Affiliations

  1. School of Medicine, University of Colorado Denver, Aurora, CO, 800453, USA

    Nazanin Kuseh Kalani Yazd

  2. Gwinnett Medical Center, Lawrenceville, GA, 30046, USA

    Ravi R. Patel

  3. Department of Dermatology, University of Colorado School of Medicine, Aurora, CO, 800453, USA

    Robert P. Dellavalle & Cory A. Dunnick

  4. Denver Veterans Affairs Medical Center (VAMC), Department of Dermatology, University of Colorado Denver, 1665 Aurora Ct, MS 703, Aurora, CO, 802204, USA

    Robert P. Dellavalle & Cory A. Dunnick

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  1. Nazanin Kuseh Kalani Yazd
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  2. Ravi R. Patel
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  3. Robert P. Dellavalle
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  4. Cory A. Dunnick
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Correspondence to Cory A. Dunnick.

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This article is part of the Topical Collection on Epidemiology

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Yazd, N.K.K., Patel, R.R., Dellavalle, R.P. et al. Genetic Risk Factors for Development of Atopic Dermatitis: a Systematic Review. Curr Derm Rep 6, 297–308 (2017). https://doi.org/10.1007/s13671-017-0199-0

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