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Association Between TSLP Polymorphisms and Eczema in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study

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Abstract

We examined the association between thymic stromal lymphopoietin (TSLP) single nucleotide polymorphisms (SNPs) and eczema in young adult Japanese women. Cases were 188 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for eczema. Controls were 565 women without eczema according to the ISAAC criteria, who had not been diagnosed with asthma, atopic eczema, and/or allergic rhinitis by a doctor and who had no asthma as defined by the European Community Respiratory Health Survey criteria and no rhinoconjunctivitis according to the ISAAC criteria. Compared with women with the TT genotype of SNP rs1837253, those with the TC or CC genotype had a significantly increased risk of eczema after adjustment for age and smoking, although this association was not significant in crude analysis. There were no relationships between SNP rs3806933 or rs2289276 and eczema. The TC and CC genotypes combined of SNP rs1837253 may be significantly positively associated with eczema.

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ACKNOWLEDGMENTS

The authors would like to thank the Kyushu Branch of the Japan Allergy Foundation, the Fukuoka Association of Obstetricians and Gynecologists, the Okinawa Association of Obstetricians and Gynecologists, the Miyazaki Association of Obstetricians and Gynecologists, the Oita Association of Obstetricians and Gynecologists, the Kumamoto Association of Obstetricians and Gynecologists, the Nagasaki Association of Obstetricians and Gynecologists, the Kagoshima Association of Obstetricians and Gynecologists, the Saga Association of Obstetricians and Gynecologists, the Fukuoka Society of Obstetrics and Gynecology, the Okinawa Society of Obstetrics and Gynecology, the Fukuoka City government, and the Fukuoka City Medical Association for their valuable support, as well as Mrs. Yukari Hayashi for her technical assistance. This study was supported by JSPS KAKENHI Grant Numbers 19590606, 20791654, 21590673, 22592355, 22119507, 24390158, 25463275, and 25670305, by Health and Labour Sciences Research Grants for Research on Allergic Disease and Immunology and Health Research on Children, Youth and Families from the Ministry of Health, Labour, and Welfare of Japan and by the Takeda Science Foundation.

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Authors and Affiliations

  1. Department of Public Health, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan

    Yoshihiro Miyake & Keiko Tanaka

  2. Total Medical Support Center, Ehime University Hospital, Ehime, Japan

    Shinichi Hitsumoto

  3. Health Tourism Research Center, Graduate School of Tourism Sciences, University of the Ryukyus, Okinawa, Japan

    Masashi Arakawa

Authors
  1. Yoshihiro Miyake
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  2. Shinichi Hitsumoto
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  3. Keiko Tanaka
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  4. Masashi Arakawa
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Correspondence to Yoshihiro Miyake.

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Miyake, Y., Hitsumoto, S., Tanaka, K. et al. Association Between TSLP Polymorphisms and Eczema in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study. Inflammation 38, 1663–1668 (2015). https://doi.org/10.1007/s10753-015-0143-z

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  • DOI: https://doi.org/10.1007/s10753-015-0143-z

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