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Vitamin D and Asthma: a Systematic Review of Clinical Trials

  • Maternal and Childhood Nutrition (AC Wood, Section Editor)
  • Published:
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Abstract

Purpose of the review

To perform a systematic review of prospective clinical trials to determine whether improving vitamin D status improves asthma control.

Recent findings

In cross sectional studies suboptimal viramin D status is often associated with poor asthma control. However, decreased 25-hydroxycholecalciferol (25 (OH) D) concentrations might not be causally associated with asthma control.

Summary

We performed a systematic review until December 15, 2021 according to PRISMA guideline, searching MEDLINE, MEDLINE In-Process, Embase, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials. Two searches were performed, the first using “vitamin D” and the second using “Vitamin D” or “ergocalciferol” or “cholecalciferol” and “Asthma”. From 419 retrieved papers, after removal of duplicate and after using exclusion criteria, 28 full-text articles were eligible, of which 6 remained for quantitative analysis and 11 (9 studies) for qualitative analysis. From both analyses, prospective studies do not support that improving the vitamin D status of asthmatic children improves asthma control.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Department of Neonatology, Shaare Zedek Medical Center, Shmuel Bait Street 12, 913102, Jerusalem, Israel

    Itamar Nitzan, Francis B. Mimouni, Alona Bin Nun, Yair Kasirer & Joseph Mendlovic

  2. Hebrew University of Jerusalem, Jerusalem, Israel

    Itamar Nitzan, Alona Bin Nun & Yair Kasirer

  3. Sackler School of Medicine, Tel Aviv, Israel

    Francis B. Mimouni & Joseph Mendlovic

  4. Recanati Business School, Tel Aviv University, Tel Aviv, Israel

    Joseph Mendlovic

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  1. Itamar Nitzan
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Correspondence to Itamar Nitzan.

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Nitzan, I., Mimouni, F.B., Nun, A.B. et al. Vitamin D and Asthma: a Systematic Review of Clinical Trials. Curr Nutr Rep 11, 311–317 (2022). https://doi.org/10.1007/s13668-022-00411-6

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