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Anticataract activity of rhamnocitrin isolated from Bauhinia variegata stem bark

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Abstract

A cataract is any clouding or opaque area in the eye’s natural lens, which is normally crystal clear, is the leading cause of blindness worldwide. It accounts for approximately 42% of all blindness. Approximately 25% of the population over 65 and about 50% over 80 age has serious loss of vision because of cataract. Most cataracts progress and eventually hamper vision. Multiple mechanisms have been implicated in the development of cataract. But the exact pathogenesis which leads to opacification is not clearly known. Oxidative damage to the lens has been recognized as the initiating event in the pathogenesis of cataracts. In cataract, the oxidation-antioxidant equilibrium shift more towards oxidative stress. Accordingly, antioxidants could prove potential anticataract agents. Rhamnocitrin, a flavonoid, possess strong antioxidant effects; can be used effectively to manage the cataract. Therefore, anticataract activity of rhamnocitrin (10, 20, 40 and 80 μg), isolated from Bauhinia variegata (Leguminosae) stem bark, was studied in ovine and chick embryo lens model. It showed a significant protection against cloudiness in lenses induced by hydrogen peroxide and hydrocortisone in a dose dependent manner. The findings suggest that rhamnocitrin possess significant anticataract activity and act most likely due to its antioxidant property.

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Acknowledgement

The authors are deeply grateful to the SLT Institute of Pharmaceutical Sciences, G. G. University, Bilaspur (C.G.)-495009 and Department of Chemistry, Govt. P. G. College, Uttarkashi, Uttarakhand, (India) for research facilities.

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Authors and Affiliations

  1. SLT Institute of Pharmaceutical Sciences, G. G. University, Bilaspur (CG), 495009, India

    Surendra H. Bodakhe, Alpana Ram & Suruchi Verma

  2. Department of Chemistry, Govt. P. G. College, Uttarkashi, Uttarakhand, India

    Devi Prasad Pandey

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  1. Surendra H. Bodakhe
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  2. Alpana Ram
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  3. Suruchi Verma
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  4. Devi Prasad Pandey
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Correspondence to Surendra H. Bodakhe.

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Bodakhe, S.H., Ram, A., Verma, S. et al. Anticataract activity of rhamnocitrin isolated from Bauhinia variegata stem bark. Orient Pharm Exp Med 12, 227–232 (2012). https://doi.org/10.1007/s13596-012-0059-1

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