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Analgesic and anti-inflammatory activities of Alocasia indica (Roxb.) Schott

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Abstract

The ethanol extract of the dried rhizome of Alocasia indica (Roxb.) Schott. (Family - Araceae) was investigated for its possible analgesic and anti-inflammatory activities in animal models. The extract showed significant (P < 0.001) writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 300 and 600 mg/kg of body weight comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. Moreover, when given orally to rats at dose of 300 and 600 mg/kg of body weight, the extract showed a significant (P < 0.001) anti-inflammatory activity against carrageenin induced paw edema in rats which was comparable to the standard drug aspirin at the dose of 150 mg/kg of body weight. The overall results tend to suggest the analgesic and anti-inflammatory activities of the crude ethanolic extract of dried rhizome of Alocasia indica (Roxb.) Schott. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.

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Acknowledgements

The authors are thankful to Prof. Dr. Samir Kumar Sadhu, Head, Pharmacy Discipline, Khulna University; Dr. Asish Kumar Das, Associate Professor, Pharmacy Discipline, Khulna University and Dr. Mahiuddin Alamgir, Research Scientist, National Measurement institute (NMI), Australia, for their encouragement during the research time. The authors are also thankful to Dr. Shahabuddin Kabir Chowdhury, Professor, Pharmacy Department, Jahangirnagar University, for giving permission to use their lab facilities for all pharmacological screenings. All the informants of the study area are cordially acknowledged for their valuable cooperation.

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Authors and Affiliations

  1. Pharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh

    Md. Atiqur Rahman, Md. Solaiman, Md. Ekramul Haque & A. K. Das

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  1. Md. Atiqur Rahman
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  2. Md. Solaiman
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  3. Md. Ekramul Haque
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  4. A. K. Das
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Correspondence to Md. Atiqur Rahman.

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Rahman, M.A., Solaiman, M., Haque, M.E. et al. Analgesic and anti-inflammatory activities of Alocasia indica (Roxb.) Schott . Orient Pharm Exp Med 11, 143–146 (2011). https://doi.org/10.1007/s13596-011-0027-1

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  • DOI: https://doi.org/10.1007/s13596-011-0027-1

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