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N-Stearoyl Chitosan as a Coating Material for Liposomes Encapsulating Itraconazole

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Abstract

Since the discovery of liposomes, this technology has been evolving from the studying of biological membranes to various multidisciplinary studies, especially cosmeceuticals and pharmaceuticals. However, the conventional liposomes encountered many challenges such as metabolite by the process of phagocytosis, instability in plasma, and short half-life. In this study, we synthesized 41 kDa N-stearoyl chitosan to be used as a stealth coating materials for soy lecithin liposomes. Soy lecithin liposomes were prepared using the thin-film hydration technique and coated with N-stearoyl chitosan, which reduced the average particle size of liposomes down to 36% and zeta potential to −15.2 mV. The morphology of liposomes was further confirmed to be spherical in shape by using the optical polarizing microscope. More than 90% of itraconazole (ITZ) was successfully encapsulated, while the in vitro release studies showed a significantly slower release of ITZ from N-stearoyl chitosan-coated soy lecithin liposomes as compared to free ITZ. These indicated that N-stearoyl chitosan could possibly be a good coating material for soy lecithin liposomes carrying various antifungal and antiviral drugs.

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Acknowledgements

This work was fully supported by the University of Malaya through GPF065B-2018, and Fundamental Research Grant Scheme (FRGS) (FP075-2018A). Dr. Vicit Rizal and Dr. Anita Marlina were supported through UM Post-Doctoral Research Fellow Scheme. The authors would like to thanks the members of Colloid Lab, Department of Chemistry, UM, members of Translational Core Laboratory, who provided insight and expertise that greatly assisted the research.

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Authors and Affiliations

  1. Colloid Laboratory, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia

    Vicit Rizal Eh Suk, Anita Marlina & Misni Misran

  2. Department of Physiology, Faculty of Medicine, Umm Al-Qura University (UQU), Makkah, Saudi Arabia

    Zahir Hussain

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  1. Vicit Rizal Eh Suk
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Correspondence to Vicit Rizal Eh Suk.

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Eh Suk, V.R., Marlina, A., Hussain, Z. et al. N-Stearoyl Chitosan as a Coating Material for Liposomes Encapsulating Itraconazole. Arab J Sci Eng 46, 5645–5653 (2021). https://doi.org/10.1007/s13369-020-05327-3

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  • DOI: https://doi.org/10.1007/s13369-020-05327-3

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