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Beta-amyloid (Aβ) uptake by PET imaging in older HIV+ and HIV- individuals

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Abstract

The causes of cognitive impairment among older HIV+ individuals may overlap with causes among elderly HIV seronegative (HIV-) individuals. The objective of this study was to determine if beta-amyloid (Aβ) deposition measured by [18F] AV-45 (florbetapir) positron emission tomography (PET) is increased in older HIV+ individuals compared to HIV- individuals. Forty-eight HIV+ and 25 HIV- individuals underwent [18F] AV-45 PET imaging. [18F] AV-45 binding to Aβ was measured by standardized uptake value ratios (SUVR) relative to the cerebellum in 16 cortical and subcortical regions of interest. Global and regional cortical SUVRs were compared by (1) serostatus, (2) HAND stage, and (3) age decade, comparing individuals in their 50s and > 60s. There were no differences in median global cortical SUVR stratified by HIV serostatus or HAND stage. The proportion of HIV+ participants in their 50s with elevated global amyloid uptake (SUVR > 1.40) was significantly higher than the proportion in HIV- participants (67% versus 25%, p = 0.04), and selected regional SUVR values were also higher (p < 0.05) in HIV+ compared to HIV- participants in their 50s. However, these group differences were not seen in participants in their 60s. In conclusion, PET imaging found no differences in overall global Aβ deposition stratified by HIV serostatus or HAND stage. Although there was some evidence of increased Aβ deposition in HIV+ individuals in their 50s compared to HIV- individuals which might indicate premature aging, the most parsimonious explanation for this is the relatively small sample size in this cross-sectional cohort study.

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Acknowledgments

The authors would like to thank Dr. Noble George for assistance in obtaining the PET scans and Marie Sonderman for administrative assistance. The authors also wish to thank all of the volunteers for their participation in the study.

Funding

This study is supported by NIH RO1NS081196, P41EB015909, and P30MH075673.

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Authors and Affiliations

  1. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Mona Mohamed, Yun Zhou, Weiguo Ye, James R. Brasic, Peter B. Barker & Dean F. Wong

  2. Department of Neurology, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, 301 Building, Suite 2100, Baltimore, MD, 21224, USA

    Richard L. Skolasky, Amanda Brown, Carlos A. Pardo, Dean F. Wong & Ned Sacktor

  3. Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Richard L. Skolasky

  4. Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA

    Yun Zhou

  5. F.M. Kirby Center for Functional Brain Imaging, the Kennedy Krieger Institute, Baltimore, MD, USA

    Peter B. Barker

  6. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Dean F. Wong

  7. Department of Neurosciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Dean F. Wong

  8. Department of Environmental Sciences and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA

    Dean F. Wong

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  1. Mona Mohamed
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  2. Richard L. Skolasky
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  4. Weiguo Ye
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  6. Amanda Brown
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  7. Carlos A. Pardo
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  10. Ned Sacktor
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Correspondence to Ned Sacktor.

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Conflict of interest

Dr. Wong has received contracts and has collaborations with Avid, Roche, Cerveau, and Lundbeck. The other authors have no conflicts of interest relevant to this paper.

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Mohamed, M., Skolasky, R.L., Zhou, Y. et al. Beta-amyloid (Aβ) uptake by PET imaging in older HIV+ and HIV- individuals. J. Neurovirol. 26, 382–390 (2020). https://doi.org/10.1007/s13365-020-00836-1

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  • DOI: https://doi.org/10.1007/s13365-020-00836-1

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