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Peripheral neuropathy in ART-experienced patients: prevalence and risk factors

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Abstract

Peripheral neuropathy (PN) is a common neurological complication of HIV infection that has debilitating effects on quality of life. While there has been a comprehensive evaluation of the prevalence of neuropathic signs/symptoms and risk factors (RFs) for PN or symptomatic PN (SPN) with initiation of combination antiretroviral therapy (cART) in ART-naïve patients, similar evaluation in ART-experienced patients is limited. This study investigated the prevalence and RFs for PN/SPN in ART-experienced patients enrolled in clinical salvage therapy studies. Between February 2000 and June 2007, 522 ART-experienced participants who experienced virologic failure with a prior regimen and started new regimens were followed longitudinally and annually screened for signs and symptoms of PN. Rates of PN/SPN at 3 years since parent study entry were 52.8 and 24.0 %, respectively. Aging, taller height, protease inhibitor use, and female sex were significant RFs for PN/SPN. The use of statin drugs was significantly associated with lower odds of SPN, and it may prevent progression from no SPN to SPN.

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Acknowledgments

This work was supported by National Institute of Health (NIH) grants including the Neurologic AIDS Research Consortium grant NS32228 from NINDS, the AIDS Clinical Trials Grant AI068636 from NIAID, and the Statistical and Data Management Center of the Adult AIDS Clinical Trials Group grant 1 U01 068634. The authors acknowledge the generous dedication of the many participants volunteering for the ALLRT study, and for the contributions of the contributing AIDS Clinical Trials Units, their investigators and staffs, that collected the samples and clinical data used for this analysis. The authors would like to thank reviewers for their thoughtful comments.

Conflict of Interest

Scott R. Evans has grant funding from NIH. The other authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Harvard School of Public Health, 651 Huntington Avenue, FXB-607, Boston, MA, 02115, USA

    Huichao Chen, Lijuan Deng, Kunling Wu, Anthony J. Lee, Ronald J. Bosch & Scott R. Evans

  2. Washington University, Saint Louis, MO, USA

    David B. Clifford

  3. University of Pittsburgh, Pittsburgh, PA, USA

    Sharon A. Riddler

  4. University of California at San Diego, San Diego, CA, USA

    Ronald J. Ellis

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  1. Huichao Chen
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  2. David B. Clifford
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  3. Lijuan Deng
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  4. Kunling Wu
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  5. Anthony J. Lee
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  7. Sharon A. Riddler
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  8. Ronald J. Ellis
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  9. Scott R. Evans
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Correspondence to Huichao Chen.

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Chen, H., Clifford, D.B., Deng, L. et al. Peripheral neuropathy in ART-experienced patients: prevalence and risk factors. J. Neurovirol. 19, 557–564 (2013). https://doi.org/10.1007/s13365-013-0216-4

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  • DOI: https://doi.org/10.1007/s13365-013-0216-4

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