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Sarcopenia in elderly patients with type 2 diabetes mellitus: prevalence and related clinical factors

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Abstract

Aims

Sarcopenia, which shortens healthy life expectancy, has recently been attracting attention because the Japanese population is rapidly aging. In this preliminary study, we estimated the prevalence of elderly diabetic patients who were complicated with sarcopenia and searched for any related clinical factors.

Methods

Elderly (≥65 years of age) Japanese patients with type 2 diabetes mellitus were recruited by asking doctors to supply candidates for the study. The prevalence of sarcopenia was estimated based on the criteria proposed by the Asian Working Group for Sarcopenia in 2014.

Results

Two hundred eighty-eight patients (151 males) were accepted for the study. The prevalence of sarcopenia was 15.2% in males and 15.3% in females. Multiple logistic regression analysis indicated that sarcopenia was significantly correlated with serum high-sensitivity C-reactive protein in females, in addition to age and body mass index. Female patients were then classified into four groups according to the presence or absence of impaired muscle mass and/or impaired strength. Serum high-sensitivity C-reactive protein was significantly higher in the sarcopenia group (those with impaired muscle mass and impaired strength) than in the other three groups.

Conclusions

After clarifying the prevalence of sarcopenia in elderly Japanese patients with type 2 diabetes mellitus, we found that serum high-sensitivity C-reactive protein was significantly higher in female patients with sarcopenia than in female patients without sarcopenia. Elevated serum high-sensitivity C-reactive protein requires impaired muscle mass and impaired strength.

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Acknowledgements

No specific grant from funding agencies in the public, commercial, or not-for-profit sectors was received for this research.

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Authors and Affiliations

  1. Clinical Center for Diabetes, Fuchu Hospital, Seichokai Social Medical Corporation, 1-10-17 Hiko-cho, Izumi-shi, Osaka, 594-0076, Japan

    Yuko Murata, Yoshiki Kadoya & Shoichi Yamada

  2. Institute for Diabetes, Fuchu Hospital, Seichokai Social Medical Corporation, 1-10-17 Hiko-cho, Izumi-shi, Osaka, 594-0076, Japan

    Tokio Sanke

Authors
  1. Yuko Murata
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  2. Yoshiki Kadoya
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  3. Shoichi Yamada
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  4. Tokio Sanke
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Corresponding author

Correspondence to Tokio Sanke.

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The authors declare no conflict of interest.

Human rights statement

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions of it.

Informed consent

Informed consent was obtained from all patients before they were included in the study.

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Murata, Y., Kadoya, Y., Yamada, S. et al. Sarcopenia in elderly patients with type 2 diabetes mellitus: prevalence and related clinical factors. Diabetol Int 9, 136–142 (2018). https://doi.org/10.1007/s13340-017-0339-6

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  • DOI: https://doi.org/10.1007/s13340-017-0339-6

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