Abstract
Sarcopenia has recently attracted widespread attention, because it increases risks of fall and bedridden. Although patients with type 2 diabetes mellitus (T2DM) are known to have lower muscle mass of limbs than healthy people, the mechanism is still unclear. We thus examined the association of muscle mass with parameters of endogenous insulin secretion such as fasting immunoreactive insulin, fasting C-peptide immunoreactivity (CPR), and daily urine CPR in 191 men with T2DM. Muscle mass of arms and legs was evaluated by dual-energy X-ray absorptiometry, and we calculated relative skeletal muscle index (RSMI), which is useful for the diagnosis of sarcopenia. Multiple regression analyses adjusted for age, duration of T2DM, serum creatinine, HbA1c, and insulin-like growth factor-I showed that each parameter of endogenous insulin was significantly and positively correlated with muscle mass of arms and legs as well as RSMI (p < 0.05). Moreover, logistic regression analyses adjusted for confounding factors mentioned above showed that each parameter of endogenous insulin was significantly lower in subjects with sarcopenia than those without it (p < 0.05). In conclusion, reduction in endogenous insulin secretion is an independent risk factor of sarcopenia in men with T2DM.
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References
Andersen H, Nielsen S, Mogensen CE et al (2004) Muscle strength in type 2 diabetes. Diabetes 53:1543–1548
Tajiri Y, Kato T, Nakayama H et al (2010) Reduction of skeletal muscle, especially in lower limbs, in Japanese type 2 diabetic patients with insulin resistance and cardiovascular risk factors. Metab Syndr Relat Disord 8:137–142
Park SW, Goodpaster BH, Lee JS et al (2009) Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care 32:1993–1997
Park SW, Goodpaster BH, Strotmeyer ES et al (2007) Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes Care 30:1507–1512
Asplund K (1975) Protein synthesis and amino acid accumulation during development in the rat: dissociation of diaphragm and heart muscle sensitivity to insulin. Horm Res 6(1):12–19
Bonadonna RC, Saccomani MP, Cobelli C et al (1993) Effect of insulin on system A amino acid transport in human skeletal muscle. J Clin Invest 91(2):514–521
Adams GR, McCue SA (1998) Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. J Appl Physiol 84:1716–1722
Kostka T, Arsac LM, Patricot MC et al (2000) Leg extensor power and dehydroepiandrosterone sulfate, insulin-like growth factor-I and testosterone in healthy active elderly people. Eur J Appl Physiol 82:83–90
Schiaffino S, Dyar KA, Ciciliot S et al (2013) Mechanisms regulating skeletal muscle growth and atrophy. FEBS J 280:4294–4314
Cappola AR, Bandeen-Roche K, Wand GS et al (2001) Association of IGF-I levels with muscle strength and mobility in older women. J Clin Endocrinol Metab 86:4139–4146
Previs SF, Withers DJ, Ren JM et al (2000) Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. J Biol Chem 275(50):38990–38994
Daughaday WH, Phillips LS, Mueller MC (1976) The effects of insulin and growth hormone on the release of somatomedin by the isolated rat liver. Endocrinology 98:1214–1219
Scott CD, Baxter RC (1986) Production of insulin-like growth factor I and its binding protein in rat hepatocytes cultured from diabetic and insulin-treated diabetic rats. Endocrinology 119:2346–2352
Kanazawa I, Yamaguchi T, Sugimoto T (2011) Serum insulin-like growth factor-I is a marker for assessing the severity of vertebral fractures in postmenopausal women with type 2 diabetes mellitus. Osteoporos Int 22:1191–1198
Kanazawa I, Yamamoto M, Yamaguchi T et al (2011) Effects of metformin and pioglitazone on serum pentosidine levels in type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 119:362–365
Seino Y, Nanjo K, Tajima N et al (2010) Report of the Committee on the classification and diagnostic criteria of diabetes mellitus. Diabetol Int 1:2–20
Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al (2010) Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39(4):412–423
Yoshida N, Okumura K, Aso Y (2005) High serum pentosidine concentrations are associated with increased arterial stiffness and thickness in patients with type 2 diabetes. Metabolism 54:345–365
Sanada K, Miyachi M, Tanimoto M et al (2010) A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors. Eur J Appl Physiol 110:57–65
Srikanthan P, Karlamangla AS (2010) Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab 96:2898–2903
Kuo JZ, Guo X, Klein R et al (2014) Association of fasting insulin and C peptide with diabetic retinopathy in Latinos with type 2 diabetes. BMJ Open Diabetes Res Care. doi:10.1136/bmjdrc-2014-000027
Baumgartner RN, Wayne SJ, Waters DL et al (2004) Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly. Obes Res 12(12):1995–2004
Janssen I, Baumgartner RN, Ross R et al (2004) Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol 159(4):413–421
Fujimoto WY (1996) Overview of non-insulin-dependent diabetes mellitus (NIDDM) in different population groups. Diabet Med 13:S7–10
Shishikura K, Tanimoto K, Sakai S et al (2014) Association between skeletal muscle mass and insulin secretion in patients with type 2 diabetes mellitus. Endocr J 61(3):281–287
McMahon CD, Chai R, Radley-Crabb HG et al (2014) Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice. Scand J Med Sci Sports 24:e423–435
Conflict of interest
All authors Ken-ichiro Tanaka, Ippei Kanazawa, and Toshitsugu Sugimoto have any conflict of interest.
Human and Animal Rights and Informed Consent
All subjects agreed to participate in this study and gave informed consent. This study was approved by the institutional review board of Shimane University Faculty of Medicine and complied with the Helsinki declaration.
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Tanaka, Ki., Kanazawa, I. & Sugimoto, T. Reduction in Endogenous Insulin Secretion is a Risk Factor of Sarcopenia in Men with Type 2 Diabetes Mellitus. Calcif Tissue Int 97, 385–390 (2015). https://doi.org/10.1007/s00223-015-9990-8
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DOI: https://doi.org/10.1007/s00223-015-9990-8