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Neuroimaging the Epileptogenic Process

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Neurotherapeutics

Abstract

Epilepsy is one of the most common chronic neurological conditions worldwide. Anti-epileptic drugs (AEDs) can suppress seizures, but do not affect the underlying epileptic state, and many epilepsy patients are unable to attain seizure control with AEDs. To cure or prevent epilepsy, disease-modifying interventions that inhibit or reverse the disease process of epileptogenesis must be developed. A major limitation in the development and implementation of such an intervention is the current poor understanding, and the lack of reliable biomarkers, of the epileptogenic process. Neuroimaging represents a non-invasive medical and research tool with the ability to identify early pathophysiological changes involved in epileptogenesis, monitor disease progression, and assess the effectiveness of possible therapies. Here we will provide an overview of studies conducted in animal models and in patients with epilepsy that have utilized various neuroimaging modalities to investigate epileptogenesis.

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The authors declare there is no real or perceived conflict of interest. Full conflict of interest disclosures are available in the electronic supplementary material for this article.

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Authors and Affiliations

  1. Department of Medicine, The Melbourne Brain Centre, The Royal Melbourne Hospital, The University of Melbourne, Building 144, Royal Parade, Parkville, VIC, 3010, Australia

    Sandy R. Shultz & Terence J. O’Brien

  2. Department of Neurology, Comprehensive Epilepsy Center, NYU Langone Medical Center, New York, NY, USA

    Maria Stefanidou & Ruben I. Kuzniecky

Authors
  1. Sandy R. Shultz
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  2. Terence J. O’Brien
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  3. Maria Stefanidou
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  4. Ruben I. Kuzniecky
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Correspondence to Sandy R. Shultz.

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Shultz, S.R., O’Brien, T.J., Stefanidou, M. et al. Neuroimaging the Epileptogenic Process. Neurotherapeutics 11, 347–357 (2014). https://doi.org/10.1007/s13311-014-0258-1

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