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Small nucleolar RNAs functioning and potential roles in cancer

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Tumor Biology

Abstract

Non-coding RNAs (ncRNAs) are important regulatory molecules involved in various physiological and pathological cellular processes. Small nucleolar RNAs (snoRNAs), subclass of small ncRNAs, have been considered important but unglamorous elements in the production of protein synthesis machinery of cells. However, recent evidence has indicated that these non-coding RNAs might have a crucial role also in controlling cell behavior, and snoRNAs dysfunction could significantly contribute to carcinogenesis. Here, we summarize the most important aspects of snoRNAs biology, their functioning in cancer cell, and potential usage in diagnosis or as a new class of therapeutic targets in cancer.

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Acknowledgments

This work was supported by the project “Employment of Best Young Scientists for International Cooperation Empowerment” (CZ.1.07/2.3.00/30.0037), co-financed from the European Social Fund and the state budget of the Czech Republic, by the project “CEITEC—Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) and by the project MZ CR–RVO (MOU, 00209805). The authors would like to thank Andrej Besse for preparation of the figures and John B. Smith for proofreading the manuscript.

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  1. Central European Institute of Technology, Masaryk University, Kamenice 753/5, 62500, Brno, Czech Republic

    Nithyananda Thorenoor & Ondrej Slaby

  2. Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic

    Ondrej Slaby

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Thorenoor, N., Slaby, O. Small nucleolar RNAs functioning and potential roles in cancer. Tumor Biol. 36, 41–53 (2015). https://doi.org/10.1007/s13277-014-2818-8

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