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TOP Genes: A Translationally Controlled Class of Genes Including Those Coding for Ribosomal Proteins

  • Chapter
Cytoplasmic fate of messenger RNA

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 18))

Abstract

In the early 1980s, it was recognized that the equimolar accumulation of ribosomal proteins (r-proteins) in eukaryotes is maintained by coordinated regulation at various levels of gene expression, from transcription to protein stability. With the possible exception of yeast, the translational control of mRNA utilization emerged to be the prevalent regulatory mechanism involved. It was also soon realized that the corresponding r-protein genes share a common architecture, mainly in the region surrounding the 5´ end, that was found to be involved in the coregulated expression of gene activity at the transcriptional and translational levels. As described below the most typical common structural feature is the transcription initiation site which is always situated within a 12–25 pyrimidine tract flanked by regions of high G + C content.

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Authors and Affiliations

  1. Dipartimento di Biologia, Università di Roma “Tor Vergata”, via della Ricerca Scientifica, 00133, Rome, Italy

    F. Amaldi

  2. Istituto di Biologia Cellulare, CNR, Via Marx 43, 00137, Roma, Italy

    P. Pierandrei-Amaldi

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  1. F. Amaldi
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  1. Institut de Génétique Moléculaire, C.N.R.S., 1919 route de Mende, B.P. 5051, 34033, Montpellier Cedex 01, France

    Philippe Jeanteur

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Amaldi, F., Pierandrei-Amaldi, P. (1997). TOP Genes: A Translationally Controlled Class of Genes Including Those Coding for Ribosomal Proteins. In: Jeanteur, P. (eds) Cytoplasmic fate of messenger RNA. Progress in Molecular and Subcellular Biology, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60471-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-60471-3_1

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