Abstract
Many genetic variations in the promoter region of tumor necrosis factor alpha (TNF-α) may confer host susceptibility to cancer by influencing TNF-α expression. Nevertheless, the results remain inconclusive. The current meta-analysis was performed to investigate the association between three common TNF-α promoter polymorphisms and the risk of non-Hodgkin lymphoma (NHL). A literature search was conducted mainly from PubMed for all eligible studies. The pooled odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were used to assess the association of TNF-α polymorphisms with the risk of NHL. TNF-α −308 A allele showed a statistically significant increased risk for NHL under the homozygous (AA vs. GG, OR = 1.51, 95 % CI = 1.26–1.80) and recessive (OR = 1.47, 95 % CI = 1.23–1.75) models, respectively. The stratified analyses showed an increased risk of NHL with the presence of TNF-α −308 A allele among Africans and Caucasians, but a decreased risk among Asians. No association was observed between −238 G/A polymorphism and NHL risk either in the overall analysis or in the stratified analysis. Similarly, pooled analysis did not reveal an altered risk of NHL with −857 C/T polymorphism. Nonetheless, a statistically significant association was observed among Asians when stratified by ethnicity. Among the three genetic variations of interest, TNF-α −308 G/A polymorphism was significantly associated with the risk of NHL; neither −238 G/A nor −857 C/T polymorphism was shown to alter the overall NHL risk; however, stratified analysis by ethnicity observed a statistically significant association between −857 C/T polymorphism and the risk of NHL among Asians.
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This study was supported by grants from the National Science Fund for Distinguished Young Scholars (Grant No. 81325018), the key project for International Cooperation and Exchange of the National Natural Science Foundation of China (Grant No. 81220108022), and Special Financial Grant from the China Postdoctoral Science Foundation (Grant No. 2014T70836).
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Yong-Qiao He and Jin-Hong Zhu contribute equally to this work.
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He, YQ., Zhu, JH., Huang, SY. et al. The association between the polymorphisms of TNF-α and non-Hodgkin lymphoma: a meta-analysis. Tumor Biol. 35, 12509–12517 (2014). https://doi.org/10.1007/s13277-014-2569-6
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DOI: https://doi.org/10.1007/s13277-014-2569-6