Skip to main content

Advertisement

SpringerLink
Log in

Association between TNF-α gene 308G>A polymorphism and lung cancer risk: a meta-analysis

  • Research Article
  • Published:
Tumor Biology

Abstract

Many studies have investigated the association between tumor necrosis factor alpha (TNF-α) gene 308G/A polymorphism and lung cancer risk, but the results were inconsistent. We thus comprehensively searched the PubMed, EMBASE, and BIOSIS Previews databases and extracted data from all eligible articles to estimate the association between TNF-α gene 308G/A polymorphism and lung cancer risk. The pooled odds ratio (OR) with 95 % confidence intervals (CIs) were calculated. Twelve case–control studies in 11 articles involving 2,436 cases and 2,573 controls were included in the meta-analysis to assess the association between TNF-α gene 308G>A polymorphism and susceptibility to lung cancer. Overall, TNF-α gene 308G>A polymorphism was significantly associated with an increased risk of lung cancer for A vs. G (OR = 1.13, 95 % CI 1.00 ~ 1.27, P = 0.04). Subgroup analysis by ethnicity showed that there was a significant association between TNF-α gene 308G>A polymorphism and increased risk of lung cancer in Asians, but not in Caucasians. In subgroup analysis by tumor type, there were significant associations between TNF-α gene 308G>A polymorphism and increased risk of lung cancer in small cell lung cancer (SCLC) for AA+AG vs. GG, in non-small cell lung cancer (NSCLC) for A vs. G, AA vs. GG, and AA+AG vs. GG. No association between the genotypes and different stages of lung cancer was detected. The meta-analysis suggests that TNF-α gene 308G>A polymorphism is associated with an increased risk of lung cancer, particularly among Asians, both for SCLC and NSCLC, considering tumor type.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med. 2008;359:1367–80.

    Article  CAS  PubMed  Google Scholar 

  2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71–96.

    Article  PubMed  Google Scholar 

  3. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.

    Article  PubMed  Google Scholar 

  4. Ozlu T, Bulbul Y. Smoking and lung cancer. Tuberk Toraks. 2005;53:200–9.

    PubMed  Google Scholar 

  5. Tokuhata GK, Lilienfeld AM. Familial aggregation of lung cancer among hospital patients. Public Health Rep. 1963;78:277–83.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Sellers TA, Bailey-Wilson JE, Elston RC, Wilson AF, Elston GZ, Ooi WL, et al. Evidence for Mendelian inheritance in the pathogenesis of lung cancer. J Natl Cancer Inst. 1990;82:1272–9.

    Article  CAS  PubMed  Google Scholar 

  7. Sellers TA, Chen PL, Potter JD, Bailey-Wilson JE, Rothschild H, Elston RC. Segregation analysis of smoking-associated malignancies: evidence for Mendelian inheritance. Am J Med Genet. 1994;52:308–14.

    Article  CAS  PubMed  Google Scholar 

  8. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Matanic D, Beg-Zec Z, Stojanovic D, Matakoric N, Flego V, Milevoj-Ribic F. Cytokines in patients with lung cancer. Scand J Immunol. 2003;57:173–8.

    Article  CAS  PubMed  Google Scholar 

  10. Brichory FM, Misek DE, Yim AM, Krause MC, Giordano TJ, Beer DG, et al. An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer. Proc Natl Acad Sci U S A. 2001;98:9824–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. McKeown DJ, Brown DJ, Kelly A, Wallace AM, McMillan DC. The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancer. Br J Cancer. 2004;91:1993–5.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Szlosarek PW, Balkwill FR. Tumour necrosis factor alpha: a potential target for the therapy of solid tumours. Lancet Oncol. 2003;4:565–73.

    Article  CAS  PubMed  Google Scholar 

  13. Waters JP, Pober JS, Bradley JR. Tumour necrosis factor and cancer. J Pathol. 2013;230:241–8.

    Article  CAS  PubMed  Google Scholar 

  14. Yang Y, Luo C, Feng R, Bi S. The TNF-alpha, IL-1B and IL-10 polymorphisms and risk for hepatocellular carcinoma: a meta-analysis. J Cancer Res Clin Oncol. 2011;137:947–52.

    Article  CAS  PubMed  Google Scholar 

  15. Shen C, Sun H, Sun D, Xu L, Zhang X, Liu A, et al. Polymorphisms of tumor necrosis factor-alpha and breast cancer risk: a meta-analysis. Breast Cancer Res Treat. 2011;126:763–70.

    Article  CAS  PubMed  Google Scholar 

  16. Zhang J, Dou C, Song Y, Ji C, Gu S, Xie Y, et al. Polymorphisms of tumor necrosis factor-alpha are associated with increased susceptibility to gastric cancer: a meta-analysis. J Hum Genet. 2008;53:479–89.

    Article  CAS  PubMed  Google Scholar 

  17. Colakogullari M, Ulukaya E, Oral AY, Aymak F, Basturk B, Ursavas A, et al. The involvement of IL-10, IL-6, IFN-gamma, TNF-alpha and TGF-beta gene polymorphisms among Turkish lung cancer patients. Cell Biochem Funct. 2008;26:283–90.

    Article  CAS  PubMed  Google Scholar 

  18. Flego V, Badovinac AR, Bulat-Kardum L, Matanic D, Crnic-Martinovic M, Kapovic M, et al. Primary lung cancer and TNF-(alpha) gene polymorphisms: a case-control study in a Croatian population. Med Sci Monit. 2009;15:R361–5.

    Google Scholar 

  19. Flego V, Ristic S, Devic Pavlic S, Matanic Lender D, Bulat-Kardum L, Kapovic M, et al. Tumor necrosis factor-alpha gene promoter -308 and -238 polymorphisms in patients with lung cancer as a second primary tumor. Med Sci Monit. 2013;19:846–51.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  20. Helmig S, Aliahmadi N, Schneider J. Tumour necrosis factor-alpha gene polymorphisms in asbestos-induced diseases. Biomarkers. 2010;15:400–9.

    Article  CAS  PubMed  Google Scholar 

  21. Huang Y. BYLM: TNF-alpha gene polymorphism in patients with lung squamous carcinoma. Natl Med J China. 2005;15:1064–5.

    Google Scholar 

  22. Kaabachi S, Kaabachi W, Rafrafi A, Belkis H, Hamzaoui K, Sassi FH. Tumor necrosis factor gene polymorphisms in Tunisian patients with non-small cell lung cancer. Clin Lab. 2013;59:1389–95.

    CAS  PubMed  Google Scholar 

  23. Kim JH, Hong YC. No association between tumor necrosis factor-alpha gene polymorphisms and lung cancer risk. Environ Health Toxicol. 2013;28:e2013012.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Seifart C, Plagens A, Dempfle A, Clostermann U, Vogelmeier C, von Wichert P, et al. TNF-alpha, TNF-beta, IL-6, and IL-10 polymorphisms in patients with lung cancer. Dis Markers. 2005;21:157–65.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. Shih C, Lee Y. Role of tumour necrosis factor alpha-gene polymorphisms (-238 and -308) in non-small cell lung cancer susceptibility and severity. Lung Cancer-J IASLC. 2005;49:S145.

    Article  Google Scholar 

  26. Stankovic MM, Nestorovic AR, Tomovic AM, Petrovic-Stanojevic ND, Andjelic-Jelic MS, Dopudja-Pantic VB, et al. TNF-(alpha)-308 promotor polymorphism in patients with chronic obstructive pulmonary disease and lung cancer. Neoplasma. 2009;56:348–52.

    Article  CAS  PubMed  Google Scholar 

  27. Van Dyke AL, Cote ML, Wenzlaff AS, Chen W, Abrams J, Land S, et al. Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. Cancer Epidemiol Biomarkers Prev. 2009;18:1829–40.

    Article  PubMed Central  PubMed  Google Scholar 

  28. Peng WJ, He Q, Yang JX, Wang BX, Lu MM, Wang S, et al. Meta-analysis of association between cytokine gene polymorphisms and lung cancer risk. Mol Biol Rep. 2012;39:5187–94.

    Article  CAS  PubMed  Google Scholar 

  29. Wang J, Cao C, Luo H, Xiong S, Xu Y, Xiong W. Tumour necrosis factor alpha -308G/A polymorphism and risk of the four most frequent cancers: a meta-analysis. Int J Immunogenet. 2011;38:311–20.

    Article  CAS  PubMed  Google Scholar 

  30. Goldstraw P, Ball D, Jett JR, Le Chevalier T, Lim E, Nicholson AG, et al. Non-small-cell lung cancer. Lancet. 2011;378:1727–40.

    Article  PubMed  Google Scholar 

  31. Huang G, Cai S, Wang W, Zhang Q, Liu A. Association between XRCC1 and XRCC3 polymorphisms with lung cancer risk: a meta-analysis from case-control studies. PLoS One. 2013;8:e68457.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  32. Huang SX, Wu FX, Luo M, Ma L, Gao KF, Li J, et al. The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies. PLoS One. 2013;8:e56722.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  33. Pennica D, Nedwin GE, Hayflick JS, Seeburg PH, Derynck R, Palladino MA, et al. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature. 1984;312:724–9.

    Article  CAS  PubMed  Google Scholar 

  34. Tracey KJ, Wei H, Manogue KR, Fong Y, Hesse DG, Nguyen HT, et al. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J Exp Med. 1988;167:1211–27.

    Article  CAS  PubMed  Google Scholar 

  35. Wu Y, Antony S, Meitzler JL, Doroshow JH. Molecular mechanisms underlying chronic inflammation-associated cancers. Cancer Lett. 2014;345:164–73.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  36. Kroeger KM, Carville KS, Abraham LJ. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol. 1997;34:391–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou, Guangdong, China

    Haojun Xie, Yating Huo & Yuanxiong Cheng

  2. Department of Respiratory Medicine, Guizhou Provincial People’s Hospital, Guiyang, China

    Hongmei Yao

  3. Department of Respiratory and Critical Care Medicine, Shantou Central Hospital, Guangdong, China

    Ning Li

Authors
  1. Haojun Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hongmei Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yating Huo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ning Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yuanxiong Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yuanxiong Cheng.

Additional information

Haojun Xie and Hongmei Yao equally contributed to the study and should be considered as first authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xie, H., Yao, H., Huo, Y. et al. Association between TNF-α gene 308G>A polymorphism and lung cancer risk: a meta-analysis. Tumor Biol. 35, 9693–9699 (2014). https://doi.org/10.1007/s13277-014-2265-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-014-2265-6

Keywords

Search

Navigation