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The TNF-α, IL-1B and IL-10 polymorphisms and risk for hepatocellular carcinoma: a meta-analysis

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Abstract

Objective

TNF-α-308 G/A, TNF-α-238 G/A, IL-1B-31 T/C, IL-1B-511 C/T, and IL-10-1082 G/A polymorphisms have been reported to influence the risk for hepatocellular carcinoma (HCC) in many studies; however, the results still remains controversial and ambiguous. The aim of this study was to determine more precise estimations for the relationship between TNF-α, IL-1B, and IL-10 polymorphisms and the risk for HCC by meta-analysis.

Methods

Electronic searches for all publications were conducted on associations between these variants and HCC in several databases through September 2010. Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated to estimate the strength of this association in a random-effect model. Twenty studies were identified, involving 2,763 HCC patients and 4,152 controls.

Results

This meta-analysis showed significant association between TNF-α-308 polymorphism and HCC (AA + GA vs. GG: OR = 1.74, 95% CI = 1.12–2.72). In Caucasian and Asian subgroups, OR values (95% CI) were 1.49 (0.58–3.82) and 1.84 (1.06–3.20), respectively. While the ORs for TNF-α-238 G/A, IL-1B-31 T/C, -511 C/T and IL-10-1082 G/A polymorphisms and HCC were 1.37 (0.95–2.00), 1.24 (0.99–1.55), 1.12 (0.66–1.88) and 0.91 (0.74–1.12), respectively. The sensitivity analysis further strengthened the overall strong positive correlations. No publication bias was observed in this study.

Conclusions

TNF-α-308 G/A polymorphism is assumed to confer a higher risk for HCC, especially in Asian population. TNF-α-238 G/A, IL-1B-31 T/C, -511 C/T, and IL-10-1082 G/A polymorphisms were not detected to be related to the risk for HCC.

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Acknowledgments

This work was supported by Harbin Special Funds for Research of Scientific and Technological Innovative Talents (No. RC2011QN004139).

Conflict of interest

The authors do not have any conflicts of interest to report with for this manuscript.

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Authors and Affiliations

  1. The Central Laboratory, Department of Neurology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Road, 150001, Harbin, Nangang, People’s Republic of China

    Sheng Bi

  2. Department of Oncology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China

    Yu Yang

  3. Department of Hygienic Toxicology, School of Public Health, Harbin Medical University, Harbin, People’s Republic of China

    Chao Luo

  4. Division of AIDS/STD Control and Prevention, Harbin Center for Disease Control and Prevention, Harbin, People’s Republic of China

    Chao Luo

  5. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, People’s Republic of China

    R. Feng

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  1. Yu Yang
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  2. Chao Luo
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  3. R. Feng
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  4. Sheng Bi
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Corresponding author

Correspondence to Sheng Bi.

Additional information

Yu Yang and Chao Luo contributed equally to this work.

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Yang, Y., Luo, C., Feng, R. et al. The TNF-α, IL-1B and IL-10 polymorphisms and risk for hepatocellular carcinoma: a meta-analysis. J Cancer Res Clin Oncol 137, 947–952 (2011). https://doi.org/10.1007/s00432-010-0959-8

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  • DOI: https://doi.org/10.1007/s00432-010-0959-8

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