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The Arg188His polymorphism in the XRCC2 gene and the risk of cancer

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Tumor Biology

Abstract

The Arg188His polymorphism in the XRCC2 gene has been suggested as a risk factor for cancer with inconclusive results. The aim of the current study is to investigate the association between the polymorphism with of cancer by meta-analysis. A total of 33 case–control studies from 27 publications were included for data analyses. The results suggested that the Arg188His polymorphism was not associated with increased/decreased risk of cancer in total analysis (Arg/His+His/His vs. Arg/Arg: OR = 0.98, 95 % CI = 0.91–1.06). In the subgroup analysis by ethnicity, no statistical significant association was found in Europeans. In the subgroup analysis by cancer types, statistical significant association was found in ovarian cancer but not in other cancers. The current meta-analysis indicated that the Arg188His polymorphism in the XRCC2 gene might be a risk factor for ovarian cancer. In the future, more large-scale case–control studies are needed to validate our results.

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References

  1. Kuschel B, Auranen A, McBride S, Novik KL, Antoniou A, Lipscombe JM, et al. Variants in DNA double-strand break repair genes and breast cancer susceptibility. Hum Mol Genet. 2002;11(12):1399–407.

    Article  CAS  PubMed  Google Scholar 

  2. Curtin K, Lin WY, George R, Katory M, Shorto J, Cannon-Albright LA, et al. Genetic variants in XRCC2: new insights into colorectal cancer tumorigenesis. Cancer Epidemiol Biomark Prev. 2009;18(9):2476–84. doi:10.1158/1055-9965.EPI-09-0187.

    Article  CAS  Google Scholar 

  3. Garcia-Closas M, Egan KM, Newcomb PA, Brinton LA, Titus-Ernstoff L, Chanock S, et al. Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses. Hum Genet. 2006;119(4):376–88. doi:10.1007/s00439-006-0135-z.

    Article  CAS  PubMed  Google Scholar 

  4. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11–30. doi:10.3322/caac.21166.

    Article  PubMed  Google Scholar 

  5. Benhamou S, Tuimala J, Bouchardy C, Dayer P, Sarasin A, Hirvonen A. DNA repair gene XRCC2 and XRCC3 polymorphisms and susceptibility to cancers of the upper aerodigestive tract. Int J Cancer J int Cancer. 2004;112(5):901–4. doi:10.1002/ijc.20474.

    Article  CAS  Google Scholar 

  6. Park DJ, Lesueur F, Nguyen-Dumont T, Pertesi M, Odefrey F, Hammet F, et al. Rare mutations in XRCC2 increase the risk of breast cancer. Am J Hum Genet. 2012;90(4):734–9. doi:10.1016/j.ajhg.2012.02.027.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Perez LO, Crivaro A, Barbisan G, Poleri L, Golijow CD. XRCC2 R188H (rs3218536), XRCC3 T241M (rs861539) and R243H (rs77381814) single nucleotide polymorphisms in cervical cancer risk. Pathol Oncol Res. 2013;19(3):553–8. doi:10.1007/s12253-013-9616-2.

    Article  CAS  PubMed  Google Scholar 

  8. Pooley KA, Baynes C, Driver KE, Tyrer J, Azzato EM, Pharoah PD, et al. Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk. Cancer Epidemiol Biomark Prev. 2008;17(12):3482–9. doi:10.1158/1055-9965.EPI-08-0594.

    Article  CAS  Google Scholar 

  9. Han J, Hankinson SE, Ranu H, De Vivo I, Hunter DJ. Polymorphisms in DNA double-strand break repair genes and breast cancer risk in the Nurses’ Health Study. Carcinogenesis. 2004;25(2):189–95. doi:10.1093/carcin/bgh002.

    Article  CAS  PubMed  Google Scholar 

  10. Krupa R, Sliwinski T, Wisniewska-Jarosinska M, Chojnacki J, Wasylecka M, Dziki L, et al. Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer—a case control study. Mol Biol Rep. 2011;38(4):2849–54. doi:10.1007/s11033-010-0430-6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Matullo G, Guarrera S, Sacerdote C, Polidoro S, Davico L, Gamberini S, et al. Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case–control study. Cancer Epidemiol Biomark Prev. 2005;14(11 Pt 1):2569–78. doi:10.1158/1055-9965.EPI-05-0189.

    Article  CAS  Google Scholar 

  12. Zhang Y, He J, Deng Y, Zhang J, Li X, Xiang Z, et al. The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene and cancer risk: a meta-analysis. BMC Med Genet. 2011;12:159. doi:10.1186/1471-2350-12-159.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Auranen A, Song H, Waterfall C, Dicioccio RA, Kuschel B, Kjaer SK, et al. Polymorphisms in DNA repair genes and epithelial ovarian cancer risk. Int J Cancer J Int Cancer. 2005;117(4):611–8. doi:10.1002/ijc.21047.

    Article  CAS  Google Scholar 

  14. Beesley J, Jordan SJ, Spurdle AB, Song H, Ramus SJ, Kjaer SK, et al. Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set. Cancer Epidemiol Biomark Prev. 2007;16(12):2557–65. doi:10.1158/1055-9965.EPI-07-0542.

    Article  CAS  Google Scholar 

  15. Millikan RC, Player JS, Decotret AR, Tse CK, Keku T. Polymorphisms in DNA repair genes, medical exposure to ionizing radiation, and breast cancer risk. Cancer Epidemiol Biomark Prev. 2005;14(10):2326–34. doi:10.1158/1055-9965.EPI-05-0186.

    Article  CAS  Google Scholar 

  16. Webb PM, Hopper JL, Newman B, Chen X, Kelemen L, Giles GG, et al. Double-strand break repair gene polymorphisms and risk of breast or ovarian cancer. Cancer Epidemiol Biomark Prev. 2005;14(2):319–23. doi:10.1158/1055-9965.EPI-04-0335.

    Article  CAS  Google Scholar 

  17. Bastos HN, Antao MR, Silva SN, Azevedo AP, Manita I, Teixeira V, et al. Association of polymorphisms in genes of the homologous recombination DNA repair pathway and thyroid cancer risk. Thyroid. 2009;19(10):1067–75. doi:10.1089/thy.2009.0099.

    Article  CAS  PubMed  Google Scholar 

  18. Brooks J, Shore RE, Zeleniuch-Jacquotte A, Currie D, Afanasyeva Y, Koenig KL, et al. Polymorphisms in RAD51, XRCC2, and XRCC3 are not related to breast cancer risk. Cancer Epidemiol Biomark Prev. 2008;17(4):1016–9. doi:10.1158/1055-9965.EPI-08-0065.

    Article  CAS  Google Scholar 

  19. Fayaz S, Fard-Esfahani P, Fard-Esfahani A, Mostafavi E, Meshkani R, Mirmiranpour H, et al. Assessment of genetic mutations in the XRCC2 coding region by high resolution melting curve analysis and the risk of differentiated thyroid carcinoma in Iran. Genet Mol Biol. 2012;35(1):32–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Figueroa JD, Malats N, Rothman N, Real FX, Silverman D, Kogevinas M, et al. Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk. Carcinogenesis. 2007;28(8):1788–93. doi:10.1093/carcin/bgm132.

    Article  CAS  PubMed  Google Scholar 

  21. Garcia-Quispes WA, Perez-Machado G, Akdi A, Pastor S, Galofre P, Biarnes F, et al. Association studies of OGG1, XRCC1, XRCC2 and XRCC3 polymorphisms with differentiated thyroid cancer. Mutat Res. 2011;709–710:67–72. doi:10.1016/j.mrfmmm.2011.03.003.

    Article  PubMed  Google Scholar 

  22. Han J, Colditz GA, Samson LD, Hunter DJ. Polymorphisms in DNA double-strand break repair genes and skin cancer risk. Cancer Res. 2004;64(9):3009–13.

    Article  CAS  PubMed  Google Scholar 

  23. Han J, Hankinson SE, Hunter DJ, De Vivo I. Genetic variations in XRCC2 and XRCC3 are not associated with endometrial cancer risk. Cancer Epidemiol Biomark Prev. 2004;13(2):330–1.

    Article  CAS  Google Scholar 

  24. Jiao L, Hassan MM, Bondy ML, Wolff RA, Evans DB, Abbruzzese JL, et al. XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer. Am J Gastroenterol. 2008;103(2):360–7. doi:10.1111/j.1572-0241.2007.01615.x.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Rafii S, O’Regan P, Xinarianos G, Azmy I, Stephenson T, Reed M, et al. A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer. Hum Mol Genet. 2002;11(12):1433–8.

    Article  CAS  PubMed  Google Scholar 

  26. Rajaraman P, Hutchinson A, Wichner S, Black PM, Fine HA, Loeffler JS, et al. DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro Oncol. 2010;12(1):37–48.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  27. Romanowicz-Makowska H, Smolarz B, Gajecka M, Kiwerska K, Rydzanicz M, Kaczmarczyk D, et al. Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population. Arch Med Sci. 2012;8(6):1065–75. doi:10.5114/aoms.2012.32417.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Romanowicz-Makowska H, Smolarz B, Zadrozny M, Westfal B, Baszczynski J, Polac I, et al. Single nucleotide polymorphisms in the homologous recombination repair genes and breast cancer risk in Polish women. Tohoku J Exp Med. 2011;224(3):201–8.

    Article  CAS  PubMed  Google Scholar 

  29. Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, et al. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis. 2006;27(3):560–7. doi:10.1093/carcin/bgi232.

    Article  CAS  PubMed  Google Scholar 

  30. Romanowicz H, Smolarz B, Baszczynski J, Zadrozny M, Kulig A. Genetics polymorphism in DNA repair genes by base excision repair pathway (XRCC1) and homologous recombination (XRCC2 and RAD51) and the risk of breast carcinoma in the Polish population. Pol J Pathol. 2010;61(4):206–12.

    CAS  PubMed  Google Scholar 

  31. Romanowicz-Makowska H, Smolarz B, Zadrozny M, Westfa B, Baszczynski J, Kokolaszwili G, et al. The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland. Eur J Gynaecol Oncol. 2012;33(2):145–50.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. The Periodical Press of West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan, 610041, China

    Yonggang Zhang & Liang Du

  2. West China Hospital/West China Medical School, Sichuan University, Chengdu, Sichuan, 610041, China

    Haichuan Wang, Yuanling Peng, Yuqi Liu, Tianyuan Xiong & Pei Xue

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  1. Yonggang Zhang
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  2. Haichuan Wang
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  7. Liang Du
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Correspondence to Liang Du.

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Zhang, Y., Wang, H., Peng, Y. et al. The Arg188His polymorphism in the XRCC2 gene and the risk of cancer. Tumor Biol. 35, 3541–3549 (2014). https://doi.org/10.1007/s13277-013-1468-6

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  • DOI: https://doi.org/10.1007/s13277-013-1468-6

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