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The upregulation of programmed death 1 on peripheral blood T cells of glioma is correlated with disease progression

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Tumor Biology

Abstract

Glioma is the most common primary brain tumor. Programmed death 1 (PD-1) is a surface receptor expressed on activated and exhausted T cells, which mediate T cell inhibition upon binding with its ligand. In the current study, we investigated the expression of PD-1 on peripheral CD4+ and CD8+ T cells in glioma patients. Percentage of PD-1+ cells was measured by flow cytometry in 86 glioma cases and 62 healthy controls. Results showed that PD-1 expression was significantly increased in both peripheral CD4+ and CD8+ T cells in glioma (p < 0.001 and p < 0.001, respectively). When comparing PD-1 level in glioma patients with different histological types, patients with astrocytomas revealed clearly higher proportion of PD-1 on CD4+ T cells than those with oligodendrogliomas (p < 0.001), ependymomas (p < 0.001), or pilocytic astrocytomas (p < 0.001). Also, patients with the highest tumor grade (IV) demonstrated the most elevated expression of PD-1 on both CD4+ and CD8+ T cells. Interestingly, cases with tumor grade III and IV had downregulated PD-1 level on peripheral CD4+ T cells after surgery, whereas only grade IV patients showed decreased proportion of PD-1 on CD8+ T cells after treatment. In addition, no correlation between PD-1 expression and progression to secondary glioblastoma was observed. These data suggested PD-1 may act as a positive regulator in the pathogenesis and progression of glioma.

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Authors and Affiliations

  1. The Second Division of Neurosurgery, The China-Japan Union Hospital of Jilin University, 126 Xiantai Street, Changchun, Jilin, 130033, China

    Bo Wei, Xingli Zhao, Chao Du, Yongchuan Guo & Zhigang Sun

  2. The First Division of Ophthalmology, The First Affiliated Hospital of Jilin University, Changchun, Jilin, 130021, China

    Le Wang

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  1. Bo Wei
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  2. Le Wang
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  3. Xingli Zhao
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  4. Chao Du
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  5. Yongchuan Guo
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  6. Zhigang Sun
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Correspondence to Zhigang Sun.

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Bo Wei and Le Wang contributed equally to this work.

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Wei, B., Wang, L., Zhao, X. et al. The upregulation of programmed death 1 on peripheral blood T cells of glioma is correlated with disease progression. Tumor Biol. 35, 2923–2929 (2014). https://doi.org/10.1007/s13277-013-1376-9

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  • DOI: https://doi.org/10.1007/s13277-013-1376-9

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