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The prognostic role of CD68 and FoxP3 expression in patients with primary central nervous system lymphoma

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Abstract

The prognostic role of CD68 and FoxP3 in primary central nervous system lymphoma (PCNSL) has not been evaluated. Thus, we examined the prognostic significance of CD68 and FoxP3 expression in tumor samples of 76 newly diagnosed immunocompetent PCNSL patients. All patients were treated initially with high-dose methotrexate (HD-MTX)-based chemotherapy, and 16 (21.1%) patients received upfront autologous stem cell transplantation (ASCT) consolidation. High expression of CD68 (>55 cells/high-power field) or FoxP3 (>15 cells/high-power field) was observed in 10 patients, respectively. High CD68 expression was associated with inferior overall survival (OS) and progression-free survival (PFS) in multivariate analysis (P = 0.023 and P = 0.021, respectively). In addition, we performed subgroup analysis based on upfront ASCT. High CD68 expression was also associated with inferior OS and PFS in multivariate analysis (P = 0.013 and P < 0.001, respectively) among patients who did not receive upfront ASCT (n = 60), but not in patients who received upfront ASCT. The expression of FoxP3 was not significantly associated with survival. Therefore, we identified a prognostic significance of high CD68 expression in PCNSL, which suggests a need for further clinical trials and biological studies on the role of PCNSL tumor microenvironment.

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Acknowledgements

This study was presented in the form of poster presentation at the 57th annual meeting of the American Society of Hematology, Orlando, FL, December 5–8, 2015.

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Author notes

  1. Hyunsoo Cho

    Present address: Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea

Authors and Affiliations

  1. Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea

    Hyunsoo Cho, Soo-Jeong Kim, June-Won Cheong, Yu Ri Kim, Jung Yeon Lee, Ji Eun Jang, Yundeok Kim, Yoo Hong Min & Jin Seok Kim

  2. Department of Pathology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea

    Se Hoon Kim & Woo Ick Yang

  3. Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea

    Jong Hee Chang

  4. Department of Radiation Oncology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea

    Chang-Ok Suh

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  1. Hyunsoo Cho
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  13. Jin Seok Kim
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Correspondence to Jin Seok Kim.

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This study was supported by a faculty research grant of Yonsei University College of Medicine for 2014 (6-2014-0113).

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The authors declare that they have no conflict of interest.

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Cho, H., Kim, S.H., Kim, SJ. et al. The prognostic role of CD68 and FoxP3 expression in patients with primary central nervous system lymphoma. Ann Hematol 96, 1163–1173 (2017). https://doi.org/10.1007/s00277-017-3014-x

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  • DOI: https://doi.org/10.1007/s00277-017-3014-x

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