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Association between IL-4 -589C>T polymorphism and colorectal cancer risk

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Tumor Biology

Abstract

In order to make a comprehensive assessment of the potential association between interleukin-4 (IL-4) -589C>T and colorectal cancer (CRC) susceptibility, we conducted a meta-analysis of six epidemiological studies, which included 1,317 CRC patients and 1,659 controls. The data showed that IL-4 -589C>T was not associated with increased CRC risk in the overall population. In the subgroup analysis of IL-4 -589C>T, the results did not change when the analyses were restricted to race. Based on this meta-analysis, we conclude that IL-4 -589C>T may be not a risk factor for CRC development. Further research is needed to assess possible gene–gene or gene–environment–lifestyle interactions on CRC.

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Authors and Affiliations

  1. Proctology Department, Liaocheng People’s Hospital, Liaocheng City, 252000, Shandong Province, China

    Qiang Li

  2. Ultrasonography Department, Liaocheng People’s Hospital, Liaocheng City, Shandong Province, China

    Qian Wang

  3. Neurology Department, Liaocheng People’s Hospital, Liaocheng City, Shandong Province, China

    Xiaoyan Xu

  4. Department of Neurosurgery, Liaocheng People’s Hospital, Liaocheng City, Shandong Province, China

    Songtao Ren

  5. Department of Gynaecology and Obstetrics, Liaocheng People’s Hospital, Liaocheng City, Shandong Province, China

    Li Wang

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  1. Qiang Li
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  5. Li Wang
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Correspondence to Qiang Li.

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Li, Q., Wang, Q., Xu, X. et al. Association between IL-4 -589C>T polymorphism and colorectal cancer risk. Tumor Biol. 35, 2675–2679 (2014). https://doi.org/10.1007/s13277-013-1352-4

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  • DOI: https://doi.org/10.1007/s13277-013-1352-4

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