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Association between Cyclin D1 polymorphism and oral cancer susceptibility: a meta-analysis

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Tumor Biology

Abstract

Data from several case–control studies on the relation between the Cyclin D1 (CCND1) G870A polymorphism and oral cancer susceptibility implicated conflicting conclusions. Thus, a meta-analysis was performed to derive a more precise evaluation of the association. We searched PubMed and Embase for related studies that had been published in English and eight available studies were finally included in the meta-analysis. Odd ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each study. Our meta-analysis suggested that CCND1 G870A polymorphism was not associated with oral cancer risk (OR AA vs. GG = 1.08, 95 % CI = 0.90–1.30, P heterogeneity = 0.175; OR AA + GA vs. GG = 1.02, 95 % CI = 0.91–1.14, P heterogeneity = 0.781; OR AA vs. GA + GG = 1.16, 95 % CI = 0.98–1.36, P heterogeneity = 0.107; OR A vs. G = 1.05 95 % CI = 0.96–1.15, P heterogeneity = 0.211; OR GA vs. GG = 0.94, 95 % CI = 0.82–1.08, P heterogeneity = 0.935). However, in the subgroup analysis by ethnicity, possible significance among Asian groups was indicated in two genetic models (OR AA vs. GA + GG = 1.27, 95 % CI = 1.05–1.54, P heterogeneity = 0.572; OR allele A vs. allele G = 1.11, 95 % CI = 1.00–1.24, P heterogeneity = 0.211). Taken together, the meta-analysis revealed that CCND1 G870A polymorphism might be correlated with the susceptibility of oral cancer in Asians.

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Funding

This work was supported by Liaoning Medical University Youth Science and Technology Foundation (no. Y2012Z008), Liaoning Foundation of Education Department (no. L2012309), Liaoning Natural Science Fund Project (no. 20102135), and Liaoning Natural Science Fund Project of Science and Technology (no. 2013022029).

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Authors and Affiliations

  1. Department of Prosthodontics, the Affiliated Hospital of Stomatology and The Second Affiliated Hospital, Liaoning Medical University, Guta District, Jinzhou, 121001, Liaoning Province, China

    Lili Wang & Xin Li

  2. Department of Oral Implantology, the Affiliated Hospital of Stomatology and The Second Affiliated Hospital, Liaoning Medical University, Guta District, Jinzhou, 121001, Liaoning Province, China

    Zhiying Wang

  3. Department of Comprehensive Dentistry and Oral Medicine, the Affiliated Hospital of Stomatology and The Second Affiliated Hospital, Liaoning Medical University, Guta District, Jinzhou, 121001, Liaoning Province, China

    Xiuqiu Gao & Xirao Sun

  4. Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Stomatology, Liaoning Medical University, Guta District, Jinzhou, 121001, Liaoning Province, China

    Changfu Liu

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  1. Lili Wang
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Correspondence to Zhiying Wang.

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Wang, L., Wang, Z., Gao, X. et al. Association between Cyclin D1 polymorphism and oral cancer susceptibility: a meta-analysis. Tumor Biol. 35, 1149–1155 (2014). https://doi.org/10.1007/s13277-013-1154-8

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  • DOI: https://doi.org/10.1007/s13277-013-1154-8

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