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Cyclin D1 polymorphism and oral cancer: a meta-analysis

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Abstract

Cyclin D1 (CCND1) plays a critical role in the G1 to S-phase cell cycle transition. Data on the association between the CCND1 A870G polymorphism and oral cancer are conflicting. To assess the relationship between the CCND1 A870G genotype and the risk of developing oral cancer, we performed a meta-analysis. We searched PubMed to December 1, 2011, for studies on this topic that had been published in the English. For each study, we calculated odds ratios (ORs) and 95 % confidence intervals (CIs), assuming the frequency of allele comparison, homozygote comparison, recessive and dominant genetic models. We then calculated pooled ORs and 95 % CIs. Seven studies were included in the meta-analysis. The CCND1 G allele was not associated with oral cancer in the frequency of allele comparison (G vs. A: OR = 0.882; 95 % CI = 0.684–1.137; p = 0.001 for heterogeneity). In the subgroup analysis, the CCND1 G allele was associated with a borderline significantly decreased risk of developing oral cancer in Asians in the frequency of allele comparison (G vs. A: OR = 0.800; 95 % CI = 0.636–1.006; p = 0.089 for heterogeneity), and the association between the GG genotype and oral cancer was significant in Asians with respect to both the homozygote comparison (GG vs. AA: OR = 0.644; 95 % CI = 0.491–0.843; p = 0.186 for heterogeneity) and the dominant genetic model (GG + AG vs. AA: OR = 0.713; 95 % CI = 0.584–0.870; p = 0.293 for heterogeneity). Our analysis provides evidence that genotypes for the CCND1 A870G polymorphism may be associated with an increased risk of developing oral cancer in the Asian population.

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Abbreviations

CI:

Confidence interval

CCND1:

Cyclin D1

OR:

Odds ratio

MAF:

Minor allele frequency

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Acknowledgments

This study was supported by a grant from the National Natural Science Foundation of China (81170928).

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All authors have no disclosures or conflict of interest.

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Authors and Affiliations

  1. Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing, 100081, People’s Republic of China

    Wenjun Wang, Yuming Zhao, Jie Yang, Bichen Lin & Lihong Ge

  2. Research Center for Cardiovascular Regenerative Medicine The Ministry of Health of China, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

    Haiyong Gu & Xiaoqing Cao

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  1. Wenjun Wang
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  2. Yuming Zhao
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  3. Jie Yang
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  4. Bichen Lin
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  5. Haiyong Gu
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  6. Xiaoqing Cao
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  7. Lihong Ge
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Correspondence to Lihong Ge.

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Wang, W., Zhao, Y., Yang, J. et al. Cyclin D1 polymorphism and oral cancer: a meta-analysis. Mol Biol Rep 40, 87–95 (2013). https://doi.org/10.1007/s11033-012-2025-x

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  • DOI: https://doi.org/10.1007/s11033-012-2025-x

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