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Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis

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Tumor Biology

Abstract

A number of studies investigated the impact of matrix metalloproteinase 2 (MMP2) expression on the survival of patients with osteosarcoma, but no consistent results were reported. To derive a more precise estimate of the prognostic role of MMP2 expression in patients with osteosarcoma, we systematically reviewed the published studies and carried out a meta-analysis. Cohort studies assessing the prognostic role of MMP2 expression in patients with osteosarcoma were included. Pooled risk ratio (RR) with 95 % confidence intervals (95%CI) was used to assess the prognostic role of MMP2 expression. Five cohort studies were eligible in the meta-analysis. Overall, high MMP2 expression was associated with increased risk of mortality in patients with osteosarcoma during the follow-up (fixed effects RR = 2.14, 95%CI 1.66–2.75, P < 0.001). Sensitivity analysis suggested that the pooled RR was stable and omitting a single study did not change the significance of the pooled RR. There was some possibility of publication bias risk in the meta-analysis. In conclusion, the meta-analysis suggests that osteosarcoma patients with high MMP2 expression have poorer prognosis compared with those with low MMP2 expression.

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Authors and Affiliations

  1. Department of Orthopedics Surgery, Xinyu People’s Hospital, Xinyu, 338025, Jiangxi province, China

    Xiaoyang Wen, Hui Liu, Kailong Yu & Yang Liu

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  1. Xiaoyang Wen
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  2. Hui Liu
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  3. Kailong Yu
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  4. Yang Liu
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Correspondence to Yang Liu.

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Wen, X., Liu, H., Yu, K. et al. Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis. Tumor Biol. 35, 845–848 (2014). https://doi.org/10.1007/s13277-013-1116-1

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  • DOI: https://doi.org/10.1007/s13277-013-1116-1

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