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Association between GSTP1 Ile105Val polymorphism and glioma risk: A systematic review and meta-analysis

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Tumor Biology

Abstract

Glutathione S-transferase P1 (GSTP1) gene Ile105Val polymorphism has been suggested to be involved in the development of glioma. However, the results from the studies regarding the association between GSTP1 Ile105Val polymorphism and glioma risk have been inconsistent. Thus, we performed a meta-analysis to investigate this association. Pooled odds ratios (ORs) with 95 % confidence intervals (95 %CIs) were calculated using random or fixed effects model. Nine studies with 2,078 cases and 3,970 controls were finally included into this meta-analysis. The results suggested there was no association between GSTP1 Ile105Val polymorphism and glioma risk under recessive model (OR = 1.138, 95 %CI = 0.966–1.341, P heterogeneity = 0.088, P = 0.123). Subgroup analyses by ethnicity showed there was also no association between GSTP1 Ile105Val polymorphism and glioma risk in mixed populations under recessive model (OR = 1.199, 95 %CI = 0.928–1.549, P heterogeneity = 0.060, P = 0.166) and Caucasian populations(OR = 1.097, 95 %CI = 0.885–1.360, P heterogeneity = 0.186, P = 0.398). In conclusion, the meta-analysis suggests that there is no association between GSTP1 Ile105Val polymorphism and glioma risk. However, more well-designed and larger studies are needed to further assess this association.

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References

  1. Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Ll’yasova D, et al. Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer. 2008;113:1953–68.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Wrensch M, Jenkins RB, Chang JS, Yeh RF, Xiao Y, Decker PA, et al. Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet. 2009;41:905–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Liu Y, Shete S, Hosking F, Robertson L, Houlston R, Bondy M. Genetic advances in glioma: susceptibility genes and networks. Curr Opin Genet Dev. 2010;20:239–44.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet. 2009;41:899–904.

    Article  CAS  PubMed  Google Scholar 

  5. Bethke L, Webb E, Murray A, Schoemaker M, Johansen C, Christensen HC, et al. Comprehensive analysis of the role of DNA repair gene polymorphisms on risk of glioma. Hum Mol Genet. 2008;17:800–5.

    Article  CAS  PubMed  Google Scholar 

  6. Vasieva O. The many faces of glutathione transferase pi. Curr Mol Med. 2011;11:129–39.

    Article  CAS  PubMed  Google Scholar 

  7. Strange RC, Spiteri MA, Ramachandran S, Fryer AA. Glutathione-S-transferase family of enzymes. Mutat Res. 2001;482:21–6.

    Article  CAS  PubMed  Google Scholar 

  8. Townsend D, Tew K. Cancer drugs, genetic variation and the glutathione-S-transferase gene family. Am J Pharmacogenomics. 2003;3:157–72.

    Article  CAS  PubMed  Google Scholar 

  9. Ginsberg G, Smolenski S, Hattis D, Guyton KZ, Johns DO, Sonawane B. Genetic polymorphism in glutathione transferases (GST): population distribution of GSTM1, T1, and P1 conjugating activity. J Toxicol Environ Health B Crit Rev. 2009;12:389–439.

    Article  CAS  PubMed  Google Scholar 

  10. Tang YT, Li XP, Liu TQ, Yang JR, Luo JQ, Liang ZX. A study of genetic polymorphisms of glutathione S-transferase in patients with hepatocellular carcinoma. Zhong Guo Shi Yan Zhen Duan Xue. 2012;16:660–2.

    Google Scholar 

  11. Cochran WG. The combination of estimates from different experiments. Biometrics. 1954;10:101–29.

    Article  Google Scholar 

  12. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  CAS  PubMed  Google Scholar 

  13. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    CAS  PubMed  Google Scholar 

  14. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.

    Article  CAS  PubMed  Google Scholar 

  15. Ezer R, Alonso M, Pereira E, et al. Identification of glutathione S-transferase (GST) polymorphisms in brain tumors and association with susceptibility to pediatric astrocytomas. J Neuro Oncol. 2002;59:123–34.

    Article  Google Scholar 

  16. De Roos AJ, Rothman N, Inskip PD, et al. Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2003;12:14–22.

    PubMed  Google Scholar 

  17. Butler MA, Ruder AM, Daly AK, et al. Polymorphisms in GSTM1, GSTT1, GSTP1 and NAT2 and susceptibility to primary intracranial brain gliomas. Proc Am Assoc Cancer Res. 2003;44:128.

    Google Scholar 

  18. Wrensch M, Kelsey KT, Liu M, et al. Glutathione-S-transferase variants and adult glioma. Cancer Epidemiol Biomarkers Prev. 2004;13:461–7.

    CAS  PubMed  Google Scholar 

  19. Pinarbasi H, Silig Y, Gurelik M. Genetic polymorphisms of GSTs and their association with primary brain tumor incidence. Cancer Genet Cytogenet. 2005;156:144–9.

    Article  CAS  PubMed  Google Scholar 

  20. Schwartzbaum JA, Ahlbom A, Lönn S, et al. An international case–control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2007;16:559–65.

    Article  CAS  PubMed  Google Scholar 

  21. Coutinho P, Sandim V, Oliveira JA, et al. Lack of association between glutathione S-transferase polymorphisms and primary glioma in a case–control study in Rio de Janeiro. Genet Mol Res. 2010;9:539–44.

    Article  CAS  PubMed  Google Scholar 

  22. Custódio AC, Almeida LO, Pinto GR, et al. GSTP1 Ile105Val polymorphism in astrocytomas and glioblastomas. Genet Mol Res. 2010;9:2328–34.

    Article  PubMed  Google Scholar 

  23. Zintzaras E, Lau J. Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol. 2008;61:634–45.

    Article  PubMed  Google Scholar 

  24. Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51–88.

    Article  CAS  PubMed  Google Scholar 

  25. Hayes JD, Strange RC. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology. 2000;61:154–66.

    Article  CAS  PubMed  Google Scholar 

  26. Strange RC, Fryer AA. The glutathione S-transferases: influence of polymorphism on cancer susceptibility. IARC Sci Publ. 1999;148:231–49.

    CAS  PubMed  Google Scholar 

  27. Lu S, Wang Z, Cui D, Liu H, Hao X. Glutathione S-transferase P1 Ile105Val polymorphism and breast cancer risk: a meta-analysis involving 34,658 subjects. Breast Cancer Res Treat. 2011;125:253–9.

    Article  CAS  PubMed  Google Scholar 

  28. Economopoulos KP, Sergentanis TN, Vlahos NF. Glutathione S-transferase M1, T1, and P1 polymorphisms and ovarian cancer risk: a meta-analysis. Int J Gynecol Cancer. 2010;20:732–7.

    Article  PubMed  Google Scholar 

  29. Economopoulos KP, Sergentanis TN. GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis. Eur J Cancer. 2010;46:1617–31.

    Article  CAS  PubMed  Google Scholar 

  30. Zhou Y, Li N, Zhuang W, Yin YQ, Liu GJ, Wu TX, et al. Glutathione S-transferase P1 gene polymorphism associated with gastric cancer among Caucasians. Eur J Cancer. 2009;45:1438–42.

    Article  CAS  PubMed  Google Scholar 

  31. Mo Z, Gao Y, Cao Y, Gao F, Jian L. An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a huge review. Prostate. 2009;69:662–88.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, General Hospital of Shenyang Military Area Command, Shenyang, 110840, China

    Peng Xie, Yong Liang, Guobiao Liang & Bing Liu

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  1. Peng Xie
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  2. Yong Liang
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Correspondence to Yong Liang.

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Xie, P., Liang, Y., Liang, G. et al. Association between GSTP1 Ile105Val polymorphism and glioma risk: A systematic review and meta-analysis. Tumor Biol. 35, 493–499 (2014). https://doi.org/10.1007/s13277-013-1069-4

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  • DOI: https://doi.org/10.1007/s13277-013-1069-4

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