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Effect of CDKN2A/B rs4977756 polymorphism on glioma risk: a meta-analysis of 16 studies including 24077 participants

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Abstract

So far, epidemiological studies have been performed to investigate the association of CDKN2A/B rs4977756 polymorphism and glioma risk. However, the results from different studies remain inconsistent. To clarify these conflicts and to quantitatively evaluate the effect of rs4977756 polymorphism on glioma risk, a meta-analysis was conducted using relevant published clinical studies about rs4977756 polymorphisms and glioma risk. Relevant studies concerning the association between rs4977756 polymorphism and risk of glioma were included in this meta-analysis. Odds ratio (OR) and 95 % confidence interval (CI) were calculated under fixed or random effects models when appropriate. Subgroup analyses were performed by race. This meta-analysis included 13 studies with a total of 8129 cases and 15,858 controls. The pooled results showed that there was an obvious association of CDKN2A/B rs4977756 polymorphism with risk of glioma in all four comparison models (dominant model/AG + GG vs. AA: OR = 1.36, 95 %CI = 1.20–1.54, p < 0.01; heterozygote comparison/AG vs. AA: OR = 1.31, 95 %CI = 1.12–1.53, p < 0.01; homozygote comparison/GG versus AA: OR = 1.49, 95 %CI = 1.36–1.64, p < 0.01; additive model/G vs. A: OR = 1.23, 95 %CI = 1.18–1.28, p < 0.01, respectively). For the subgroup analyses of ethnicities, similar results were observed in Caucasians. However, the association was not found between rs4977756 polymorphism and the risk of glioma in all models for the Asian studies. The CDKN2A/B rs4977756 polymorphism is obvious increase the risk of glioma in Caucasians. Future studies are needed to confirm the results in other ethnic populations.

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Acknowledgments

This work was generously supported by Grants from the Zhejiang Provincial Natural Science Foundation of China (Grant No. LY13H160003), Zhejiang Provincial Medicines Health Science and Technology Program Foundation of China (Grant No. 2013KYB162 and No. 2015KYB223).

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Authors and Affiliations

  1. Department of Neurosurgery, Sir Run Run Shaw Hospital, College of Medical Sciences, Zhejiang University, Hangzhou, 310016, China

    Xuchen Qi, Yingfeng Wan, Shuxu Yang & Yirong Wang

  2. Department of Reproductive Endocrinology, Women’s Hospital, College of Medical Sciences, Zhejiang University, Hangzhou, 310006, China

    Qitao Zhan

  3. Department of General Surgery, Sir Run Run Shaw Hospital, College of Medical Sciences, Zhejiang University, Hangzhou, 310016, China

    Xiujun Cai

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  1. Xuchen Qi
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  2. Yingfeng Wan
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  4. Shuxu Yang
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  5. Yirong Wang
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Correspondence to Xiujun Cai.

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Qi, X., Wan, Y., Zhan, Q. et al. Effect of CDKN2A/B rs4977756 polymorphism on glioma risk: a meta-analysis of 16 studies including 24077 participants. Mamm Genome 27, 1–7 (2016). https://doi.org/10.1007/s00335-015-9612-9

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  • DOI: https://doi.org/10.1007/s00335-015-9612-9

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